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Candidate pathway a...
Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk
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- Luyapan, Jennifer (author)
- Quantitative Biomedical Science Program, Geisel School of Medicine, Dartmouth College, Hanover, United States; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, United States
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- Bossé, Yohan (author)
- Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Canada; Department of Molecular Medicine, Laval University, Quebec City, Canada
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- Li, Zhonglin (author)
- Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Canada
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- Xiao, Xiangjun (author)
- Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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- Rosenberger, Albert (author)
- Institut für Genetische Epidemiologie, Georg-August-Universität Göttingen, Niedersachsen, Gottingen, Germany
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- Hung, Rayjean J. (author)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbuaum Research Institute, Sinai Health System, ON, Toronto, Canada
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- Lam, Stephen (author)
- Department of Integrative Oncology, British Columbia Cancer Agency, BC, Vancouver, Canada
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- Zienolddiny, Shanbeh (author)
- Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
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- Liu, Geoffrey (author)
- Princess Margaret Cancer Centre, Princess Margaret Research Institute, Epidemiology Division, ON, Toronto, Canada
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- Kiemeney, Lambertus A. (author)
- Department for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands
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- Chen, Chu (author)
- Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- McKay, James (author)
- International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch Lyon 69008, France
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- Johansson, Mattias (author)
- International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch Lyon 69008, France
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- Johansson, Mikael (author)
- Umeå universitet,Onkologi
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- Tardon, Adonina (author)
- Health Research Institute of the Principality of Asturias, University of Oviedo and CIBERSP, Asturias, Oviedo, Spain
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- Fernandez-Tardon, Guillermo (author)
- Health Research Institute of the Principality of Asturias, University of Oviedo and CIBERSP, Asturias, Oviedo, Spain
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- Brennan, Paul (author)
- Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig Maximillians University, Bavaria, Munich, Germany
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- Field, John K. (author)
- Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, University of Liverpool Institute of Translational Medicine, Liverpool, United Kingdom
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- Davies, Michael P. (author)
- Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, University of Liverpool Institute of Translational Medicine, Liverpool, United Kingdom
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- Woll, Penella J. (author)
- Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom
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- Cox, Angela (author)
- Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
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- Taylor, Fiona (author)
- Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
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- Arnold, Susanne M. (author)
- Division of Medical Oncology, Cancer Center, University of Kentucky, Lexington, United States
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- Lazarus, Philip (author)
- Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Landi, Maria T. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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- Christiani, David C. (author)
- Department of Environmental Health, Harvard School of Public Health, Boston, United States; Department of Medicine, Massachusetts General Hospital, Boston, United States
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- MacKenzie, Todd A. (author)
- Quantitative Biomedical Science Program, Geisel School of Medicine, Dartmouth College, Hanover, United States; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, United States
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- Amos, Christopher I. (author)
- Quantitative Biomedical Science Program, Geisel School of Medicine, Dartmouth College, Hanover, United States; Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, United States; Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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(creator_code:org_t)
- Oxford University Press, 2023
- 2023
- English.
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 32:18, s. 2842-2855
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single nucleotide polymorphisms (SNPs) of 40 surfactant-related genes and lung cancer risk using genotyped data from two independent lung cancer genome-wide association studies. Discovery data included 18,082 cases and 13,780 controls of European ancestry. Replication data included 1,914 cases and 3,065 controls of European descent. Using multivariate logistic regression, we found novel SNPs in surfactant-related genes CTSH [rs34577742 C > T, odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.89-0.93, P = 7.64 × 10-9] and SFTA2 (rs3095153 G > A, OR = 1.16, 95% CI = 1.10-1.21, P = 1.27 × 10-9) associated with overall lung cancer in the discovery data and validated in an independent replication data-CTSH (rs34577742 C > T, OR = 0.88, 95% CI = 0.80-0.96, P = 5.76 × 10-3) and SFTA2 (rs3095153 G > A, OR = 1.14, 95% CI = 1.01-1.28, P = 3.25 × 10-2). Among ever smokers, we found SNPs in CTSH (rs34577742 C > T, OR = 0.89, 95% CI = 0.85-0.92, P = 1.94 × 10-7) and SFTA2 (rs3095152 G > A, OR = 1.20, 95% CI = 1.14-1.27, P = 4.25 × 10-11) associated with overall lung cancer in the discovery data and validated in the replication data-CTSH (rs34577742 C > T, OR = 0.88, 95% CI = 0.79-0.97, P = 1.64 × 10-2) and SFTA2 (rs3095152 G > A, OR = 1.15, 95% CI = 1.01-1.30, P = 3.81 × 10-2). Subsequent transcriptome-wide association study using expression weights from a lung expression quantitative trait loci study revealed genes most strongly associated with lung cancer are CTSH (PTWAS = 2.44 × 10-4) and SFTA2 (PTWAS = 2.32 × 10-6).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Luyapan, Jennife ...
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Bossé, Yohan
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Li, Zhonglin
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Xiao, Xiangjun
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Rosenberger, Alb ...
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Hung, Rayjean J.
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Lam, Stephen
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Zienolddiny, Sha ...
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Liu, Geoffrey
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Kiemeney, Lamber ...
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Chen, Chu
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McKay, James
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Johansson, Matti ...
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Johansson, Mikae ...
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Tardon, Adonina
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Fernandez-Tardon ...
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Brennan, Paul
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Field, John K.
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Davies, Michael ...
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Woll, Penella J.
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Cox, Angela
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Taylor, Fiona
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Arnold, Susanne ...
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Lazarus, Philip
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Grankvist, Kjell
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Landi, Maria T.
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Christiani, Davi ...
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MacKenzie, Todd ...
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Amos, Christophe ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Human Molecular ...
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Umeå University