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Biomarker-based pre...
Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus
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- Haller, Paul M. (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany
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- Goßling, Alina (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany
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- Magnussen, Christina (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany
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- Brenner, Hermann (författare)
- German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 280, Heidelberg, Germany
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- Schöttker, Ben (författare)
- German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 280, Heidelberg, Germany
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- Iacoviello, Licia (författare)
- 1) Department of Epidemiology and Prevention, IRCCS NEUROMED, Via Atinense ,18, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy
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- Costanzo, Simona (författare)
- 1) Department of Epidemiology and Prevention, IRCCS NEUROMED, Via Atinense ,18, Pozzilli, Italy
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- Kee, Frank (författare)
- Centre for Public Health, Queens University of Belfast, Belfast, United Kingdom
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- Koenig, Wolfgang (författare)
- Klinik für Herz-& Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstraße 36, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance ,Lazarettstraße 36, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Helmholtzstr. 22, Ulm, Germany
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- Linneberg, Allan (författare)
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Capital Region of Denmark, Ndr. Fasanvej 57, 1. sal, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark
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- Sujana, Chaterina (författare)
- Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Epidemiology, Ingolstädter Landstraße 1, Germany
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- Thorand, Barbara (författare)
- Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Epidemiology, Ingolstädter Landstraße 1, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, Germany
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- Salomaa, Veikko (författare)
- Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland
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- Niiranen, Teemu J. (författare)
- Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland; Department of Medicine, Turku University Hospital and University of Turku, Kiinamyllynkatu 10, Turku, Finland
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- Söderberg, Stefan (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Völzke, Henry (författare)
- Institut für Community Medicine, University Medicine Greifswald ,Walter Rathenau Str. 48, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany
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- Dörr, Marcus (författare)
- German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Klinik und Poliklinik für Innere Medizin B, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany
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- Sans, Susana (författare)
- Catalan Department of Health, Roc Boronat, Barcelona, Spain
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- Padró, Teresa (författare)
- Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain
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- Felix, Stephan B. (författare)
- German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Klinik und Poliklinik für Innere Medizin B, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany
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- Nauck, Matthias (författare)
- German Center for Cardiovascular Research (DZHK), Partner Site Greifswald ,Walter Rathenau Str. 48, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany
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- Petersmann, Astrid (författare)
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald ,Ferdinand-Sauerbruch-Straße, Germany; University Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Oldenburg, Rahel-Straus-Straße 10, Oldenburg, Germany
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- Palmieri, Luigi (författare)
- Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, 299 Viale Regina Elena, Rome, Italy
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- Donfrancesco, Chiara (författare)
- Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, 299 Viale Regina Elena, Rome, Italy
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- De Ponti, Roberto (författare)
- Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy
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- Veronesi, Giovanni (författare)
- Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy
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- Ferrario, Marco M. (författare)
- Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Via O. Rossi 9, Varese, Italy
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- Kuulasmaa, Kari (författare)
- Finnish Institute for Health and Welfare, Department of Public Health and Welfare, P.O. Box 30, Helsinki, Finland
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- Zeller, Tanja (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany
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- Ojeda, Francisco M. (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany
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- Blankenberg, Stefan (författare)
- Department for Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Martinistrasse 52, Hamburg, Germany
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- Westermann, Dirk (författare)
- Department of Cardiology and Angiology, University Heart Center Freiburg • Bad Krozingen, Freiburg, Germany
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - 2047-4873 .- 2047-4881. ; 30:12, s. 1218-1226
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS: The role of biomarkers in predicting cardiovascular outcomes in high-risk individuals is not well established. We aimed to investigate benefits of adding biomarkers to cardiovascular risk assessment in individuals with and without diabetes. 'METHODS AND RESULTS: We used individual-level data of 95 292 individuals of the European population harmonized in the Biomarker for Cardiovascular Risk Assessment across Europe consortium and investigated the prognostic ability of high-sensitivity cardiac troponin I (hs-cTnI), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP). Cox-regression models were used to determine adjusted hazard ratios of diabetes and log-transformed biomarkers for fatal and non-fatal cardiovascular events. Models were compared using the likelihood ratio test. Stratification by specific biomarker cut-offs was performed for crude time-to-event analysis using Kaplan-Meier plots. Overall, 6090 (6.4%) individuals had diabetes at baseline, median follow-up was 9.9 years. Adjusting for classical risk factors and biomarkers, diabetes [HR 2.11 (95% CI 1.92, 2.32)], and all biomarkers (HR per interquartile range hs-cTnI 1.08 [95% CI 1.04, 1.12]; NT-proBNP 1.44 [95% CI 1.37, 1.53]; hs-CRP 1.27 [95% CI 1.21, 1.33]) were independently associated with cardiovascular events. Specific cut-offs for each biomarker identified a high-risk group of individuals with diabetes losing a median of 15.5 years of life compared to diabetics without elevated biomarkers. Addition of biomarkers to the Cox-model significantly improved the prediction of outcomes (likelihood ratio test for nested models P < 0.001), accompanied by an increase in the c-index (increase to 0.81).CONCLUSION: Biomarkers improve cardiovascular risk prediction in individuals with and without diabetes and facilitate the identification of individuals with diabetes at highest risk for cardiovascular events.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Biomarkers
- Cardiovascular events
- Diabetes
- hs-CRP
- hs-cTnI
- NT-proBNP
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- Av författaren/redakt...
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Haller, Paul M.
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Goßling, Alina
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Magnussen, Chris ...
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Brenner, Hermann
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Schöttker, Ben
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Iacoviello, Lici ...
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visa fler...
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Costanzo, Simona
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Kee, Frank
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Koenig, Wolfgang
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Linneberg, Allan
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Sujana, Chaterin ...
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Thorand, Barbara
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Salomaa, Veikko
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Niiranen, Teemu ...
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Söderberg, Stefa ...
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Völzke, Henry
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Dörr, Marcus
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Sans, Susana
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Padró, Teresa
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Felix, Stephan B ...
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Nauck, Matthias
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Petersmann, Astr ...
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Palmieri, Luigi
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Donfrancesco, Ch ...
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De Ponti, Robert ...
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Veronesi, Giovan ...
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Ferrario, Marco ...
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Kuulasmaa, Kari
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Zeller, Tanja
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Ojeda, Francisco ...
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Blankenberg, Ste ...
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Westermann, Dirk
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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