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A naturalistic stud...
A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment
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- Hussain, Alia Arif (författare)
- Eating Disorder Research Unit, Mental Health Center, Ballerup, Copenhagen University Hospital - Mental Health Services of the Capital Region of Denmark, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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- Carlsson, Jessica (författare)
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, Copenhagen University Hospital - Mental Health Services of the Capital Region of Denmark, Ballerup, Copenhagen, Denmark
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- Mortensen, Erik Lykke (författare)
- Unit of Medical Psychology, Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
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- Hemmingsen, Simone Daugaard (författare)
- Center for Eating Disorders, Odense University Hospital, Odense, Denmark; Research Unit for Medical Endocrinology, Odense University Hospital, Odense, Denmark; Research Unit, Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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- Bulik, Cynthia M. (författare)
- Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
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- Støving, René Klinkby (författare)
- Center for Eating Disorders, Odense University Hospital, Odense, Denmark; Research Unit for Medical Endocrinology, Odense University Hospital, Odense, Denmark; Research Unit, Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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- Sjögren, Jan Magnus (författare)
- Umeå universitet,Psykiatri,Eating Disorder Research Unit, Mental Health Center, Ballerup, Copenhagen University Hospital - Mental Health Services of the Capital Region of Denmark, Copenhagen, Denmark
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(creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: Journal of Eating Disorders. - : BioMed Central (BMC). - 2050-2974. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Plasma lipid concentrations in patients with anorexia nervosa (AN) seem to be altered.Methods: We conducted a naturalistic study with 75 adult female patients with AN and 26 healthy female controls (HC). We measured plasma lipid profile, sex hormones and used self-report questionnaires at admission and discharge.Results: Total cholesterol (median (IQR): 4.9 (1.2)) and triglycerides (TG) (1.2 (0.8)) were elevated in AN at admission (BMI 15.3 (3.4)) compared with HC (4.3 (0.7), p = 0.003 and 0.9 (0.3), p = 0.006) and remained elevated at discharge (BMI 18.9 (2.9)) after weight restoration treatment. Estradiol (0.05 (0.1)) and testosterone (0.5 (0.7)) were lower in AN compared with HC (0.3 (0.3), p = < 0.001 and 0.8 (0.5), p = 0.03) and remained low at discharge. There was no change in eating disorder symptoms. Depression symptoms decreased (33 (17) to 30.5 (19), (p = 0.007)). Regression analyses showed that illness duration was a predictor of TG, age was a predictor of total cholesterol and LDL, while educational attainment predicted LDL and TG.Conclusion: Lipid concentrations remained elevated following weight restoration treatment, suggesting an underlying, premorbid dysregulation in the lipid metabolism in AN that persists following weight restoration. Elevated lipid concentrations may be present prior to illness onset in AN.Level of evidence: III: Evidence obtained from well-designed cohort or case–control analytic studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Anorexia nervosa
- Cholesterol
- Eating disorders
- Estradiol
- Lipids
- Sex hormones
- Testosterone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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