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Age at menopause an...
Age at menopause and the risk of stroke : observational and mendelian randomization analysis in 204 244 postmenopausal women
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- Tschiderer, Lena (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria
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- Peters, Sanne A. E. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia
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- van der Schouw, Yvonne T. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
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- van Westing, Anniek C. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands
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- Tong, Tammy Y. N. (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Willeit, Peter (author)
- Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Seekircher, Lisa (author)
- Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria
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- Moreno-Iribas, Conchi (author)
- Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Huerta, José María (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Crous-Bou, Marta (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)– Bellvitge Biomedical Research Institute, (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University
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- Söderholm, Martin (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Johansson, Cecilia (author)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Själander, Sara, 1981- (author)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Heath, Alicia K. (author)
- SwedenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Macciotta, Alessandra (author)
- Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Ibsen, Daniel B. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus, Denmark; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark
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- Pala, Valeria (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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- Mellemkjær, Lene (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Burgess, Stephen (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom,Medical Research Council Biostatistics Unit
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- Wood, Angela (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
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- Katzke, Verena (author)
- Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
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- Amiano, Pilar (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Rodriguez-Barranco, Miguel (author)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Halkjær, Jytte (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Panico, Salvatore (author)
- School of Medicine, Federico II University, Naples, Italy
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- Danesh, John (author)
- BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, United Kingdom; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Human Genetics, Wellcome Sanger Institute, Saffron Walden, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom,Wellcome Trust Sanger Institute,Cambridge University Hospitals NHS Foundation Trust
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- Butterworth, Adam (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, United Kingdom; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom
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- Onland-Moret, N. Charlotte (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
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(creator_code:org_t)
- American Heart Association Inc. 2023
- 2023
- English.
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In: Journal of the American Heart Association. - : American Heart Association Inc.. - 2047-9980. ; 12:18
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear.METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8–13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95% CI, 1.07–1.12) for stroke, 1.09 (95% CI, 1.06–1.13) for ischemic stroke, 1.10 (95% CI, 1.04–1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08–1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84–1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke.CONCLUSIONS: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- age at menopause
- Mendelian randomization analysis
- observational analysis
- stroke
- age at menopause
- Mendelian randomization analysis
- observational analysis
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
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Tschiderer, Lena
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Peters, Sanne A. ...
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van der Schouw, ...
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van Westing, Ann ...
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Tong, Tammy Y. N ...
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Willeit, Peter
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show more...
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Seekircher, Lisa
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Moreno-Iribas, C ...
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Huerta, José Mar ...
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Crous-Bou, Marta
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Söderholm, Marti ...
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Schulze, Matthia ...
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Johansson, Cecil ...
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Själander, Sara, ...
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Heath, Alicia K.
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Macciotta, Aless ...
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Dahm, Christina ...
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Ibsen, Daniel B.
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Pala, Valeria
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Mellemkjær, Lene
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Burgess, Stephen
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Wood, Angela
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Kaaks, Rudolf
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Katzke, Verena
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Amiano, Pilar
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Rodriguez-Barran ...
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Engström, Gunnar
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Weiderpass, Elis ...
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Tjønneland, Anne
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Halkjær, Jytte
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Panico, Salvator ...
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Danesh, John
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Butterworth, Ada ...
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Onland-Moret, N. ...
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Umeå University
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Lund University