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Search: WFRF:(van der Schouw Yvonne T.) > (2020-2024) > Age at menopause an...

  • Tschiderer, LenaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria (author)

Age at menopause and the risk of stroke : observational and mendelian randomization analysis in 204 244 postmenopausal women

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Heart Association Inc.2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-214773
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214773URI
  • https://doi.org/10.1161/JAHA.123.030280DOI
  • https://lup.lub.lu.se/record/ba278b27-371f-400f-a562-eace75e61842URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear.METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8–13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95% CI, 1.07–1.12) for stroke, 1.09 (95% CI, 1.06–1.13) for ischemic stroke, 1.10 (95% CI, 1.04–1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08–1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84–1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke.CONCLUSIONS: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship.

Subject headings and genre

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  • Peters, Sanne A. E.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia (author)
  • van der Schouw, Yvonne T.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands (author)
  • van Westing, Anniek C.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands (author)
  • Tong, Tammy Y. N.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (author)
  • Willeit, PeterInstitute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (author)
  • Seekircher, LisaInstitute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria (author)
  • Moreno-Iribas, ConchiInstituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Huerta, José MaríaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)– Bellvitge Biomedical Research Institute, (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University (author)
  • Söderholm, MartinLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ms8 (author)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (author)
  • Johansson, CeciliaUmeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)cejo0008 (author)
  • Själander, Sara,1981-Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)saamer01 (author)
  • Heath, Alicia K.SwedenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (author)
  • Macciotta, AlessandraCentre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Turin, Italy (author)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus, Denmark (author)
  • Ibsen, Daniel B.Department of Public Health, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus, Denmark; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark (author)
  • Pala, ValeriaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (author)
  • Mellemkjær, LeneDanish Cancer Society Research Center, Copenhagen, Denmark (author)
  • Burgess, StephenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom,Medical Research Council Biostatistics Unit (author)
  • Wood, AngelaDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (author)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany (author)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany (author)
  • Amiano, PilarCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Rodriguez-Barranco, MiguelCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP) (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France (author)
  • Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (author)
  • Halkjær, JytteDanish Cancer Society Research Center, Copenhagen, Denmark (author)
  • Panico, SalvatoreSchool of Medicine, Federico II University, Naples, Italy (author)
  • Danesh, JohnBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, United Kingdom; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Human Genetics, Wellcome Sanger Institute, Saffron Walden, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom,Wellcome Trust Sanger Institute,Cambridge University Hospitals NHS Foundation Trust (author)
  • Butterworth, AdamDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, United Kingdom; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom (author)
  • Onland-Moret, N. CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands (author)
  • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, AustriaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia (creator_code:org_t)

Related titles

  • In:Journal of the American Heart Association: American Heart Association Inc.12:182047-9980

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