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The risk of thrombo...
The risk of thromboembolism in patients with muscle invasive bladder cancer before and after cystectomy depending on blood group and neoadjuvant chemotherapy : a multicentre retrospective cohort study
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- Schulz Hägersten, Emma (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Ottosson, Kristoffer (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Pelander, Sofia (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Johansson, Markus (författare)
- Umeå universitet,Urologi och andrologi,Department of Surgery, Urology Section, Sundsvall-Härnäsand Hospital, Sundsvall, Sweden,Umea Univ, Sweden; Sundsvall Harnosand Hosp, Sweden
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- Huge, Ylva (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Aljabery, Firas (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Alamdari, Farhood (författare)
- Department of Urology, Västmanland Hospital, Västerås, Sweden,Vastmanland Hosp, Sweden
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- Svensson, Johan, 1978- (författare)
- Umeå universitet,Statistik,Umea Univ, Sweden
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- Styrke, Johan (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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- Sherif, Amir (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Sweden
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Journal of Personalized Medicine. - : MDPI. - 2075-4426. ; 13:9
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- PURPOSE: Previous studies have indicated that patients with muscle-invasive bladder cancer with non-O blood types have an increased risk of experiencing thromboembolic events (TEEs). This is finding is in relation to neoadjuvant-chemotherapy (NAC)-naïve patients.AIM: to establish the risk of TEEs and any association with blood types among NAC patients as well as NAC-naïve patients.METHODS: Cystectomized patients at four centres treated from 2009 to 2018 (n = 244) were analysed. The quantities of patients corresponding to each blood group were as follows: A-108 (44%); O-99 (41%); B-30 (12%); and AB-7 (3%). NAC patients (n = 167) and NAC-naïve NAC-eligible patients (n = 77) were assessed. In total, 54 women (22%) and 190 men (78%), with a median age of 69 years, were included in the study. The occurrence of any type of TEE from six months pre-cystectomy to 12-24 months after was analysed using logistic regression adjusted for NAC and confounders.RESULTS: Sixty-six TEEs were detected in 21% of the patients (n = 52). Pulmonary embolus (n = 33) and deep venous thrombosis (n = 11) were the most common forms. No significant differences between blood types were found in the analysis, although B blood type had a nearly significant increased crude risk compared with O blood type, for which there was an OR of 2.48 (95% CI 0.98-6.36). Adjustment for NAC and covariates weakened the OR, which plummeted to 1.98 (95% CI 0.71-5.51).CONCLUSIONS: No significant associations were found between blood types and TEE occurrences in this cohort including both NAC and NAC-naïve NAC-eligible patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- ABO blood group system
- complications
- cystectomy
- neoadjuvant therapy
- thromboembolism
- urinary bladder neoplasms
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Schulz Hägersten ...
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Ottosson, Kristo ...
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Pelander, Sofia
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Johansson, Marku ...
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Huge, Ylva
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Aljabery, Firas
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Alamdari, Farhoo ...
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Svensson, Johan, ...
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Styrke, Johan
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Sherif, Amir
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Kardiologi
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Journal of Perso ...
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Umeå universitet
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Linköpings universitet