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pH regulated H. pyl...
pH regulated H. pylori adherence : implications for persistent infection and disease
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- Bugaytsova, Jeanna (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Björnhamn, Oscar (author)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik
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- Henriksson, Sara (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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show more...
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- Johansson, Pär (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Mendez, Melissa (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Sjöström, Rolf (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Brännström, Kristoffer (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Aisenbrey, Christopher (author)
- Umeå universitet,Kemiska institutionen
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- Shevtsova, Anna (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Bylund, Göran (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Mahdavi, Jafar (author)
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Ögren, Johan (author)
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Ilver, Dag (author)
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Gilman, Robert H (author)
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- Chowdhury, Abhijit (author)
- The Swedish Institute for Control, Solna, Swede
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Mukhopadhyay, Asish K (author)
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Engstrand, Lars (author)
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Oscarson, Stefan (author)
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Kelly, Charles G (author)
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Younson, Justine S (author)
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Odenbreit, Stefan (author)
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Solnick, Jay (author)
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- Gröbner, Gerhard (author)
- Umeå universitet,Kemiska institutionen
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Haas, Rainer (author)
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Dubois, Andre (author)
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- Schedin, Staffan (author)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik
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Berg, Douglas E (author)
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- Arnqvist, Anna (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Borén, Thomas (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Helicobacter pylori’s BabA adhesin binds strongly to gastric mucosal ABH/Leb glycans on the stomach epithelium and overlying mucus, materials continuously shed into the acidic gastric lumen. Here we report that this binding is acid labile, acid inactivation is fully reversible; and acid lability profiles vary with BabA sequence and correlate with disease patterns. Isogenic H. pylori strains from the gastric antrum and more acidic corpus were identified that differed in acid lability of receptor binding and in sequence near BabA’s carbohydrate binding domain. We propose that reversible acid inactivation of receptor binding helps H. pylori avoid clearance by mucosal shedding, and that strain differences in acid lability affect tissue tropism and the spectrum of associated gastric diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Bugaytsova, Jean ...
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Björnhamn, Oscar
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Henriksson, Sara
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Johansson, Pär
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Mendez, Melissa
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Sjöström, Rolf
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show more...
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Brännström, Kris ...
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Aisenbrey, Chris ...
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Shevtsova, Anna
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Bylund, Göran
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Mahdavi, Jafar
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Ögren, Johan
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Ilver, Dag
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Gilman, Robert H
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Chowdhury, Abhij ...
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Mukhopadhyay, As ...
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Engstrand, Lars
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Oscarson, Stefan
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Kelly, Charles G
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Younson, Justine ...
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Odenbreit, Stefa ...
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Solnick, Jay
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Gröbner, Gerhard
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Haas, Rainer
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Dubois, Andre
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Schedin, Staffan
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Berg, Douglas E
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Arnqvist, Anna
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Borén, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- By the university
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Umeå University