Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts

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Demnitz, NaiaraDanish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark (författare)

Characterising the covariance pattern between lifestyle factors and structural brain measures : a multivariable replication study of two independent ageing cohorts

Artikel/kapitelEngelska2023

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Elsevier,2023
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LIBRIS-ID:oai:DiVA.org:umu-214977
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214977URI
https://doi.org/10.1016/j.neurobiolaging.2023.07.023DOI

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Språk:engelska
Sammanfattning på:engelska

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Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Geriatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Geriatrics hsv//eng
Magnetic resonance imaging (MRI)
Modifiable lifestyle factors
Old age
White matter hyperintensities

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hulme, Oliver J.Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark (författare)
Siebner, Hartwig R.Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Kjaer, MichaelInstitute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Ebmeier, Klaus P.Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom (författare)
Boraxbekk, Carl-Johan,1980-Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI),Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark(Swepub:umu)olncan02 (författare)
Gillan, Claire M.School of Psychology, Trinity College Dublin, Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland (författare)
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, DenmarkDanish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark (creator_code:org_t)

Sammanhörande titlar

Ingår i:Neurobiology of Aging: Elsevier131, s. 115-1230197-45801558-1497

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Av författaren/redakt...: Demnitz, Naiara; Hulme, Oliver J.; Siebner, Hartwig ...; Kjaer, Michael; Ebmeier, Klaus P ...; Boraxbekk, Carl- ...; visa fler...; Gillan, Claire M ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Geriatrik

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Av lärosätet: Umeå universitet

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