Search: id:"swepub:oai:DiVA.org:umu-215032" >
Apitoxin and its co...
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Kohler, Andreas,1988-
(author)
Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis : limitations and possibilities
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-21
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MDPI,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-215032
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215032URI
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https://doi.org/10.3390/toxins12020066DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-181110URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409516URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Natural products represent important sources for the discovery and design of novel drugs. Bee venom and its isolated components have been intensively studied with respect to their potential to counteract or ameliorate diverse human diseases. Despite extensive research and significant advances in recent years, multifactorial diseases such as cancer, rheumatoid arthritis and neurodegenerative diseases remain major healthcare issues at present. Although pure bee venom, apitoxin, is mostly described to mediate anti-inflammatory, anti-arthritic and neuroprotective effects, its primary component melittin may represent an anticancer therapeutic. In this review, we approach the possibilities and limitations of apitoxin and its components in the treatment of these multifactorial diseases. We further discuss the observed unspecific cytotoxicity of melittin that strongly restricts its therapeutic use and review interesting possibilities of a beneficial use by selectively targeting melittin to cancer cells.
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Kohler, Verena,1992-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden(Swepub:su)veko8845
(author)
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Khalifa, ShadenStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden(Swepub:su)shkha
(author)
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Abd El-Wahed, AidaUppsala universitet,Farmakognosi,Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt; Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt
(author)
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Du, MingDalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Dalian 116024, Peoples R China
(author)
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El-Seedi, HeshamUppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China(Swepub:uu)heels173
(author)
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Büttner, SabrinaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden;Karl Franzens Univ Graz, Inst Mol Biosci, Humboldtstr 50, A-8010 Graz, Austria(Swepub:su)sab
(author)
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Aufschnaiter, AndreasStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrheniusvag 16, S-10691 Stockholm, Sweden(Swepub:su)anau1258
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Toxins: MDPI12:22072-6651
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