Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis: limitations and possibilities

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Kohler, Andreas,1988- (author)

Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis : limitations and possibilities

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-01-21
MDPI,2020
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-215032
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215032URI
https://doi.org/10.3390/toxins12020066DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-181110URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409516URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Natural products represent important sources for the discovery and design of novel drugs. Bee venom and its isolated components have been intensively studied with respect to their potential to counteract or ameliorate diverse human diseases. Despite extensive research and significant advances in recent years, multifactorial diseases such as cancer, rheumatoid arthritis and neurodegenerative diseases remain major healthcare issues at present. Although pure bee venom, apitoxin, is mostly described to mediate anti-inflammatory, anti-arthritic and neuroprotective effects, its primary component melittin may represent an anticancer therapeutic. In this review, we approach the possibilities and limitations of apitoxin and its components in the treatment of these multifactorial diseases. We further discuss the observed unspecific cytotoxicity of melittin that strongly restricts its therapeutic use and review interesting possibilities of a beneficial use by selectively targeting melittin to cancer cells.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
apamin
apitoxin
bee venom
cancer
melittin
neurodegeneration
phospholipase A2
rheumatoid arthritis

Added entries (persons, corporate bodies, meetings, titles ...)

Kohler, Verena,1992-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden(Swepub:su)veko8845 (author)
Khalifa, ShadenStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden(Swepub:su)shkha (author)
Abd El-Wahed, AidaUppsala universitet,Farmakognosi,Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt; Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt (author)
Du, MingDalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Dalian 116024, Peoples R China (author)
El-Seedi, HeshamUppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China(Swepub:uu)heels173 (author)
Büttner, SabrinaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Svante Arrheniusvag 20C, S-10691 Stockholm, Sweden;Karl Franzens Univ Graz, Inst Mol Biosci, Humboldtstr 50, A-8010 Graz, Austria(Swepub:su)sab (author)
Aufschnaiter, AndreasStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrheniusvag 16, S-10691 Stockholm, Sweden(Swepub:su)anau1258 (author)
Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

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In:Toxins: MDPI12:22072-6651

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About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

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