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Separate and combin...
Separate and combined associations of obesity and metabolic health with coronary heart disease : a pan-European case-cohort analysis
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- Lassale, Camille (författare)
- University College London,Imperial College London
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- Tzoulaki, Ioanna (författare)
- University of Ioannina,Imperial College London
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- Moons, Karel G. M. (författare)
- University Medical Center Utrecht,Human Genetics Foundation (HuGeF),University of Turin
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- Sweeting, Michael (författare)
- University of Cambridge
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- Boer, Jolanda (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Johnson, Laura (författare)
- University of Bristol
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- Huerta, José María (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization
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- Weiderpass, Elisabete (författare)
- Karolinska Institute,Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Wennberg, Patrik (författare)
- Umeå University,Umeå universitet,Allmänmedicin
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- van der A, Daphne L. (författare)
- National Institute for Public Health and the Environment (RIVM),Biodonostia Health Research Institute
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Arriola, Larraitz (författare)
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- Benetou, Vassiliki (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Bonnet, Fabrice (författare)
- University of Rennes I,Centre for Research in Epidemiology and Population Health (CESP)
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- Colorado-Yohar, Sandra M. (författare)
- Murcia Regional Health Council,University of Antioquia
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Eriksen, Anne K. (författare)
- Danish Cancer Society
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Johansson, Matthias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Katsoulis, Michail (författare)
- Hellenic Health Foundation, Athens
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- Katzke, Verena (författare)
- German Cancer Research Centre
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- Key, Timothy J. (författare)
- University of Oxford
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Matullo, Giuseppe (författare)
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Molina-Portillo, Elena (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Moreno-Iribas, Concepción (författare)
- Health Research Institute of Navarra (IDISNA)
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- Norberg, Margareta (författare)
- Umeå University,Umeå universitet,Epidemiologi och global hälsa
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- Overvad, Kim (författare)
- Aarhus University,Aalborg University
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Quirós, J. Ramón (författare)
- Public Health Directorate
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- Saieva, Calogero (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Steffen, Annika (författare)
- German Institute of Human Nutrition
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Verschuren, W. M. Monique (författare)
- National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht
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- Langenberg, Claudia (författare)
- University of Cambridge
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- Di Angelantonio, Emanuele (författare)
- University of Cambridge
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- Riboli, Elio (författare)
- Imperial College London
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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- Danesh, John (författare)
- University of Cambridge,Wellcome Trust Sanger Institute
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- Butterworth, Adam S. (författare)
- University of Cambridge
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(creator_code:org_t)
- 2017-08-14
- 2018
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 39:5, s. 397-406
- Relaterad länk:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Aims: The hypothesis of 'metabolically healthy obesity' implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk. We tested this hypothesis in a large pan-European prospective study.Methods and results: We conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study ('EPIC-CVD'). During a median follow-up of 12.2 years, we recorded 7637 incident coronary heart disease (CHD) cases. Using cut-offs recommended by guidelines, we defined obesity and overweight using body mass index (BMI), and metabolic dysfunction ('unhealthy') as ≥ 3 of elevated blood pressure, hypertriglyceridaemia, low HDL-cholesterol, hyperglycaemia, and elevated waist circumference. We calculated hazard ratios (HRs) and 95% confidence intervals (95% CI) within each country using Prentice-weighted Cox proportional hazard regressions, accounting for age, sex, centre, education, smoking, diet, and physical activity. Compared with metabolically healthy normal weight people (reference), HRs were 2.15 (95% CI: 1.79; 2.57) for unhealthy normal weight, 2.33 (1.97; 2.76) for unhealthy overweight, and 2.54 (2.21; 2.92) for unhealthy obese people. Compared with the reference group, HRs were 1.26 (1.14; 1.40) and 1.28 (1.03; 1.58) for metabolically healthy overweight and obese people, respectively. These results were robust to various sensitivity analyses.Conclusion: Irrespective of BMI, metabolically unhealthy individuals had higher CHD risk than their healthy counterparts. Conversely, irrespective of metabolic health, overweight and obese people had higher CHD risk than lean people. These findings challenge the concept of 'metabolically healthy obesity', encouraging population-wide strategies to tackle obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Adiposity
- Coronary heart disease
- Epidemiology
- Metabolic syndrome
- Obesity
- Adiposity
- Coronary heart disease
- Epidemiology
- Metabolic syndrome
- Obesity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lassale, Camille
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Tzoulaki, Ioanna
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Moons, Karel G. ...
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Sweeting, Michae ...
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Boer, Jolanda
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Johnson, Laura
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visa fler...
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Huerta, José Mar ...
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Agnoli, Claudia
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Freisling, Heinz
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Weiderpass, Elis ...
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Wennberg, Patrik
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van der A, Daphn ...
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Arriola, Larrait ...
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Benetou, Vassili ...
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Boeing, Heiner
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Bonnet, Fabrice
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Colorado-Yohar, ...
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Engström, Gunnar
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Eriksen, Anne K.
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Ferrari, Pietro
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Grioni, Sara
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Johansson, Matth ...
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Kaaks, Rudolf
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Katsoulis, Micha ...
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Katzke, Verena
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Key, Timothy J.
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Matullo, Giusepp ...
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Melander, Olle
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Molina-Portillo, ...
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Moreno-Iribas, C ...
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Norberg, Margare ...
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Overvad, Kim
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Panico, Salvator ...
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Quirós, J. Ramón
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Saieva, Calogero
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Skeie, Guri
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Steffen, Annika
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Stepien, Magdale ...
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Tjønneland, Anne
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Trichopoulou, An ...
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Tumino, Rosario
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van der Schouw, ...
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Verschuren, W. M ...
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Langenberg, Clau ...
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Di Angelantonio, ...
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Riboli, Elio
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Wareham, Nichola ...
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Danesh, John
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Butterworth, Ada ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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European Heart J ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet