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Sökning: WFRF:(Colorado Yohar S.) > Altered plasma meta...

Altered plasma metabolite levels can be detected years before a glioma diagnosis

Löding, Sebastian (författare)
Department of Chemistry
Andersson, Ulrika (författare)
Umeå universitet,Onkologi,Biobank Reserach Unit
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Pala, Valeria (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Urbarova, Ilona (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Amiano, Pilar (författare)
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastián, Spain; Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastián, Spain
Colorado-Yohar, Sandra M. (författare)
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Guevara, Marcela (författare)
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Institute of Public and Labor Health and Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Chatziioannou, Anastasia Chrysovalantou (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), Lyon, France
Johansson, Mattias (författare)
Genomic Epidemiology Branch, IARC, Lyon, France
Nyberg, Lars, 1966- (författare)
Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Diagnostisk radiologi
Antti, Henrik (författare)
Department of Chemistry
Björkblom, Benny (författare)
Department of Chemistry
Melin, Beatrice S. (författare)
Umeå universitet,Onkologi
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 (creator_code:org_t)
American Society For Clinical Investigation, 2023
2023
Engelska.
Ingår i: JCI Insight. - : American Society For Clinical Investigation. - 2379-3708. ; 8:19
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. Since gliomas are currently detected late, a liquid biopsy for early detection could affect the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 prediagnostic glioma cases and 550 healthy controls from the Northern Sweden Health and Disease study (NSHDS) and the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We identified 93 significantly altered metabolites related to glioma development up to 8 years before diagnosis. Out of these metabolites, a panel of 20 selected metabolites showed strong disease correlation and a consistent progression pattern toward diagnosis in both the NSHDS and EPIC cohorts, and they separated future cases from controls independently of biological sex. The blood metabolite panel also successfully separated both lower-grade glioma and glioblastoma cases from controls, up to 8 years before diagnosis in patients within the NSHDS cohort and up to 2 years before diagnosis in EPIC. Pathway enrichment analysis detected metabolites related to the TCA cycle, Warburg effect, gluconeogenesis, and cysteine, pyruvate, and tyrosine metabolism as the most affected.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Brain cancer
Metabolism
Oncology

Publikations- och innehållstyp

ref (ämneskategori)
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