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  • Yasinska, ValentynaClinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden (författare)

Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • European Respiratory Society,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-215705
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215705URI
  • https://doi.org/10.1183/23120541.00269-2023DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153935457URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Rationale: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure.Methods: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study.Measurements and main results: The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months.Conclusion: The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gómez, CristinaDepartment of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Kolmert, JohanDepartment of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Ericsson, MagnusDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden; Laboratoire AntiDopage Français, Université Paris-Saclay, Châtenay-Malabry, France (författare)
  • Pohanka, AntonDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden (författare)
  • James, AnnaDepartment of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Andersson, Lars I.Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden (författare)
  • Sparreman-Mikus, MariaKarolinska Institutet (författare)
  • Sousa, Ana R.Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom (författare)
  • Riley, John H.Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom (författare)
  • Bates, StewartRespiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom (författare)
  • Bakke, Per S.Institute of Clinical Science, University of Bergen, Bergen, Norway (författare)
  • Kermani, Nazanin ZounematNational Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Caruso, MassimoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy (författare)
  • Chanez, PascalAssistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France (författare)
  • Fowler, Stephen J.Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (författare)
  • Geiser, ThomasDepartment of Pulmonary Medicine, University Hospital, University of Bern, Bern, Switzerland (författare)
  • Howarth, Peter H.Faculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom (författare)
  • Horváth, IldikóDepartment of Public Health, Semmelweis University, Budapest, Hungary; National Koranyi Institute for Pulmonology, Budapest, Hungary (författare)
  • Krug, NorbertFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany (författare)
  • Montuschi, PaoloNational Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom; Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy (författare)
  • Sanak, MarekDepartment of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland (författare)
  • Behndig, Annelie F.,1963-Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anbe0145 (författare)
  • Shaw, Dominick E.Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom (författare)
  • Knowles, Richard G.Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom (författare)
  • Dahlén, BarbroClinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden (författare)
  • van der Zee, Anke-Hilse MaitlandDepartment of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands (författare)
  • Sterk, Peter J.Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands (författare)
  • Djukanovic, RatkoFaculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom (författare)
  • Adcock, Ian M.National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Chung, Kian FanNational Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Wheelock, Craig E.Karolinska Institutet (författare)
  • Dahlén, Sven-ErikClinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Jonsson, Eva WikströmKarolinska Institutet (författare)
  • Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, SwedenDepartment of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:ERJ Open Research: European Respiratory Society9:52312-0541

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