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Frailty is associat...
Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old : results from an observational study in 241 European ICUs
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- Haas, Lenneke E M (författare)
- Diakonessenhuis Utrecht, Netherlands,Univ Tripoli, Libya
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- Boumendil, Ariane (författare)
- Hop St Antoine, France
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- Flaatten, Hans (författare)
- Univ Bergen, Norway
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- Guidet, Bertrand (författare)
- Sorbonne Univ, France
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- Ibarz, Mercedes (författare)
- Univ Hosp Sagrat Cor Barcelona, Spain
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- Jung, Christian (författare)
- Heinrich Heine Univ, Germany
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- Moreno, Rui (författare)
- Univ Lisboa Cent, Portugal
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- Morandi, Alessandro (författare)
- Hosp Ancelle, Italy; Parc Sanitari Pere Virgili, Spain; Vail dHebron Inst Res, Spain
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- Andersen, Finn H (författare)
- Alesund Hosp, Norway; NTNU, Norway
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- Zafeiridis, Tilemachos (författare)
- Gen Hosp Larissa, Greece
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- Walther, Sten (författare)
- Region Östergötland, Thorax-kärlkliniken i Östergötland
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- Oeyen, Sandra (författare)
- Ghent Univ Hosp, Belgium
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- Leaver, Susannah (författare)
- NHS Fdn Trust, England
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- Watson, Ximena (författare)
- St Georges Univ Hosp, England
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- Boulanger, Carole (författare)
- Royal Devon & Exeter NHS Fdn Trust, England
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- Szczeklik, Wojciech (författare)
- Jagiellonian Univ Med Coll, Poland
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- Schefold, Joerg C (författare)
- Univ Bern, Switzerland
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- Cecconi, Maurizio (författare)
- IRCCS, Italy; Humanitas Univ, Italy
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- Marsh, Brian (författare)
- Mater Misericordiae Univ Hosp, Ireland
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- Joannidis, Michael (författare)
- Med Univ Innsbruck, Austria
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- Nalapko, Yuriy (författare)
- ICU, Ukraine
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Elhadi, Muhammed (författare)
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- Fjølner, Jesper (författare)
- Aarhus Univ Hosp, Denmark
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- Artigas, Antonio (författare)
- Autonomous Univ Barcelona, Spain
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- de Lange, Dylan W (författare)
- Univ Utrecht, Netherlands
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- Brorsson, Camilla (bidragsgivare)
- Umeå universitet,Anestesiologi och intensivvård,VIP2 study group
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(creator_code:org_t)
- 2021-03-20
- 2021
- Engelska.
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Ingår i: Age and Ageing. - : Oxford University Press. - 0002-0729 .- 1468-2834. ; 50:5, s. 1719-1727
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear.OBJECTIVE: To investigate both the short- and long-term mortality of VIPs admitted with sepsis and assess the relation of mortality with pre-existing physical and cognitive function.DESIGN: Prospective cohort study.SETTING: 241 ICUs from 22 European countries in a six-month period between May 2018 and May 2019.SUBJECTS: Acutely admitted ICU patients aged ≥80 years with sequential organ failure assessment (SOFA) score ≥ 2.METHODS: Sepsis was defined according to the sepsis 3.0 criteria. Patients with sepsis as an admission diagnosis were compared with other acutely admitted patients. In addition to patients' characteristics, disease severity, information about comorbidity and polypharmacy and pre-existing physical and cognitive function were collected.RESULTS: Out of 3,596 acutely admitted VIPs with SOFA score ≥ 2, a group of 532 patients with sepsis were compared to other admissions. Predictors for 6-month mortality were age (per 5 years): Hazard ratio (HR, 1.16 (95% confidence interval (CI), 1.09-1.25, P < 0.0001), SOFA (per one-point): HR, 1.16 (95% CI, 1.14-1.17, P < 0.0001) and frailty (CFS > 4): HR, 1.34 (95% CI, 1.18-1.51, P < 0.0001).CONCLUSIONS: There is substantial long-term mortality in VIPs admitted with sepsis. Frailty, age and disease severity were identified as predictors of long-term mortality in VIPs admitted with sepsis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- frailty
- intensive care unit (ICU)
- mortality
- sepsis
- very old people
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Haas, Lenneke E ...
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Boumendil, Arian ...
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Flaatten, Hans
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Guidet, Bertrand
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Ibarz, Mercedes
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Jung, Christian
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visa fler...
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Moreno, Rui
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Morandi, Alessan ...
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Andersen, Finn H
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Zafeiridis, Tile ...
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Walther, Sten
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Oeyen, Sandra
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Leaver, Susannah
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Watson, Ximena
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Boulanger, Carol ...
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Szczeklik, Wojci ...
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Schefold, Joerg ...
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Cecconi, Maurizi ...
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Marsh, Brian
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Joannidis, Micha ...
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Nalapko, Yuriy
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Elhadi, Muhammed
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Fjølner, Jesper
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Artigas, Antonio
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de Lange, Dylan ...
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Brorsson, Camill ...
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