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Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU : a prospective cohort study
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- Fronczek, Jakub (författare)
- Jagiellonian Univ Med Coll, Poland,Jagiellonian University
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- Polok, Kamil (författare)
- Jagiellonian Univ Med Coll, Poland,Jagiellonian University
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- de Lange, Dylan W. (författare)
- Univ Utrecht, Netherlands,Utrecht University
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- Jung, Christian (författare)
- Heinrich Heine Univ, Germany,Heinrich Heine University Düsseldorf,University Hospital of Düsseldorf
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- Beil, Michael (författare)
- Hadassah Med Ctr, Israel,Hadassah University Hospital
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- Rhodes, Andrew (författare)
- St Georges Univ Hosp NHS Fdn Trust, England,St George's, University of London
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- Fjølner, Jesper (författare)
- Aarhus Univ Hosp, Denmark,Aarhus University Hospital
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- Górka, Jacek (författare)
- Jagiellonian Univ Med Coll, Poland,Jagiellonian University
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- Andersen, Finn H. (författare)
- Alesund Hosp, Norway; NITNU, Norway,Norwegian University of Science and Technology,Ålesund Hospital
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- Artigas, Antonio (författare)
- Autonomous Univ Barcelona, Spain,Autonomous University of Barcelona
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- Cecconi, Maurizio (författare)
- Humanitas Clin & Res Ctr IRCCS, Italy; Humanitas Univ, Italy,Humanitas University
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- Christensen, Steffen (författare)
- Aarhus Univ Hosp, Denmark,Aarhus University Hospital
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- Joannidis, Michael (författare)
- Med Univ Innsbruck, Austria,Medical University of Innsbruck
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- Leaver, Susannah (författare)
- Crit Care Directorate St Georges Hosp, England,St George's Hospital, London
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- Marsh, Brian (författare)
- Mater Misericordiae Univ Hosp, Ireland,Mater Misericordiae University Hospital
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- Morandi, Alessandro (författare)
- Dept Rehabil Hosp Ancelle Cremona Italy, Italy,Hospital Ancelle di Cremona
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- Moreno, Rui (författare)
- Ctr Hosp Univ Lisboa Cent, Portugal,Hospital de São José
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- Oeyen, Sandra (författare)
- Ghent Univ Hosp, Belgium,Ghent University Hospital
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- Agvald-Öhman, Christina (författare)
- Karolinska Univ Hosp, Sweden
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- Bollen Pinto, Bernardo (författare)
- Geneva Univ Hosp, Switzerland,Geneva University Hospital
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- Schefold, Joerg C. (författare)
- Univ Bern, Switzerland,Bern University Hospital
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- Valentin, Andreas (författare)
- Kardinal Schwarzenberg Hosp, Austria,Cardinal Schwarzenberg Hospital
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- Walther, Sten (författare)
- Linköping University,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland
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- Watson, Ximena (författare)
- St Georges Univ Hosp NHS Fdn Trust, England,St George's Hospital, London
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- Zafeiridis, Tilemachos (författare)
- Gen Hosp Larissa, Greece,University Hospital of Larissa
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- Sviri, Sigal (författare)
- Hebrew Univ Jerusalem, Israel; Hebrew Univ Jerusalem, Israel,Hebrew University of Jerusalem
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- van Heerden, Peter Vernon (författare)
- Hebrew Univ Jerusalem, Israel; Hebrew Univ Jerusalem, Israel,Hebrew University of Jerusalem
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- Flaatten, Hans (författare)
- Haukeland Hosp, Norway; Univ Bergen, Norway,University of Bergen,Haukeland University Hospital
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- Guidet, Bertrand (författare)
- UPMC Univ Paris 06, France,Institut Pierre Louis d’Epidémiologie et de Santé Publique,Hospital Saint-Antoine,Paris-Sorbonne University
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- Szczeklik, Wojciech (författare)
- Jagiellonian Univ Med Coll, Poland,Jagiellonian University
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- Brorsson, Camilla (bidragsgivare)
- Umeå universitet,Anestesiologi och intensivvård
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- Agvald-Öhman, Sandra (författare)
- Karolinska University Hospital
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- Spångfors, Martin (creator_code:cre_t)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Cronberg, Tobias (creator_code:cre_t)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- 2021-07-01
- 2021
- Engelska.
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Ingår i: Critical Care. - : BioMed Central (BMC). - 1364-8535 .- 1466-609X. ; 25:1
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://umu.diva-por... (primary) (Raw object)
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https://ccforum.biom...
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context.METHODS: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient's age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score.RESULTS: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81-87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01).CONCLUSION: Knowledge about a patient's frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Aged
- 80 and over
- Frailty
- Intensive care units
- Mortality
- Prospective studies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Fronczek, Jakub
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Polok, Kamil
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de Lange, Dylan ...
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Jung, Christian
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Beil, Michael
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Rhodes, Andrew
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visa fler...
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Fjølner, Jesper
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Górka, Jacek
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Andersen, Finn H ...
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Artigas, Antonio
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Cecconi, Maurizi ...
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Christensen, Ste ...
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Joannidis, Micha ...
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Leaver, Susannah
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Marsh, Brian
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Morandi, Alessan ...
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Moreno, Rui
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Oeyen, Sandra
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Agvald-Öhman, Ch ...
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Bollen Pinto, Be ...
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Schefold, Joerg ...
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Valentin, Andrea ...
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Walther, Sten
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Watson, Ximena
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Zafeiridis, Tile ...
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Sviri, Sigal
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van Heerden, Pet ...
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Flaatten, Hans
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Guidet, Bertrand
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Szczeklik, Wojci ...
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Brorsson, Camill ...
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Agvald-Öhman, Sa ...
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Spångfors, Marti ...
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Cronberg, Tobias
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
- Artiklar i publikationen
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Critical Care
- Av lärosätet
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Umeå universitet
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Linköpings universitet
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Lunds universitet