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Serum metabolome as...
Serum metabolome associated with severity of acute traumatic brain injury
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- Thomas, Ilias, 1987- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Dickens, Alex M. (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland
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- Posti, Jussi P. (author)
- Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland
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- Czeiter, Endre (author)
- Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary
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- Duberg, Daniel, 1985- (author)
- Umeå universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Institutionen för klinisk vetenskap
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- Sinioja, Tim, 1983- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Kråkström, Matilda (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Retel Helmrich, Isabel R. A. (author)
- Department of Public Health, Center for Medical Decision Making, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
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- Wang, Kevin K. W. (author)
- Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Emergency Medicine, McKnight Brin Institute of the University of Florida, Gainesville, Florida, USA
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- Maas, Andrew I. R. (author)
- Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium
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- Steyerberg, Ewout W. (author)
- Department of Public Health, Center for Medical Decision Making, Erasmus MC-University Medical Center, Rotterdam, The Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
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- Menon, David K. (author)
- Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
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- Tenovuo, Olli (author)
- Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Büki, Andras, 1966- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Brorsson, Camilla (contributor)
- Umeå universitet,Anestesiologi och intensivvård
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- Koskinen, Lars-Owe D., Professor, 1955- (contributor)
- Umeå universitet,Institutionen för klinisk vetenskap
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- Sundström, Nina (contributor)
- Umeå universitet,Institutionen för strålningsvetenskaper
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(creator_code:org_t)
- 2022-05-10
- 2022
- English.
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In: Nature Communications. - : Nature Research. - 2041-1723. ; 13:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
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- art (subject category)
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- By the author/editor
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Thomas, Ilias, 1 ...
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Dickens, Alex M.
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Posti, Jussi P.
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Czeiter, Endre
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Duberg, Daniel, ...
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Sinioja, Tim, 19 ...
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show more...
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Kråkström, Matil ...
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Retel Helmrich, ...
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Wang, Kevin K. W ...
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Maas, Andrew I. ...
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Steyerberg, Ewou ...
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Menon, David K.
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Tenovuo, Olli
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Hyötyläinen, Tuu ...
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Büki, Andras, 19 ...
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Oresic, Matej, 1 ...
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Brorsson, Camill ...
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Koskinen, Lars-O ...
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Sundström, Nina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University
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Örebro University
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Karolinska Institutet