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Prospective and Men...
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Nimptsch, KatharinaMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany
(author)
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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BioMed Central (BMC),2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-215878
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215878URI
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https://doi.org/10.1186/s12916-023-03104-1DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach.Methods: The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry.Results: In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37).Conclusions: Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Aleksandrova, KrasimiraDepartment Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
(author)
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Pham, Thu ThiMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany
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Papadimitriou, NikosNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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Janke, JürgenMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany
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Christakoudi, SofiaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Inflammation Biology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
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Heath, AliciaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Olsen, AnjaDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark
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Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutehtal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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Katzke, VerenaDepartment of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Kaaks, RudolfDepartment of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99
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Harbs, JustinUmeå universitet,Onkologi(Swepub:umu)juha0033
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Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Macciotta, AlessandraDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Pasanisi, FabrizioDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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Yohar, Sandra Milena ColoradoDepartment of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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Guevara, MarcelaCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
(author)
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Amiano, PilarCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
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Grioni, SaraEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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Jakszyn, Paula GabrielaUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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Figueiredo, Jane C.Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute, CA, Los Angeles, United States
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Samadder, N. JewelDivision of Gastroenterology and Hepatology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, AZ, Phoenix, United States
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Li, Christopher I.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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Moreno, VictorCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L’Hospitalet de Llobregat, Barcelona, Spain
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Potter, John D.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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Schoen, Robert E.Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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Um, Caroline Y.Department of Population Science, American Cancer Society, GA, Atlanta, United States
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France
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Jenab, MazdaNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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Pischon, TobiasMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany
(author)
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Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, GermanyDepartment Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
(creator_code:org_t)
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In:BMC Medicine: BioMed Central (BMC)21:11741-7015
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Heath, Alicia
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