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  • Tong, Tammy Y. N.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United Kingdom (författare)

Dietary amino acids and risk of stroke subtypes : a prospective analysis of 356,000 participants in seven European countries

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-215965
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215965URI
  • https://doi.org/10.1007/s00394-023-03251-4DOI
  • https://lup.lub.lu.se/record/7f588e82-4889-4248-b643-a4e000643601URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose: Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study.Methods: We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids were assessed using validated country-specific dietary questionnaires, calibrated using additional 24-h dietary recalls. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of ischaemic and haemorrhagic stroke in relation to the intake of each amino acid. The role of blood pressure as a potential mechanism was assessed in 267,642 (75%) participants.Results: After a median follow-up of 12.9 years, 4295 participants had an ischaemic stroke and 1375 participants had a haemorrhagic stroke. After correction for multiple testing, a higher intake of proline (as a percent of total protein) was associated with a 12% lower risk of ischaemic stroke (HR per 1 SD higher intake 0.88; 95% CI 0.82, 0.94). The association persisted after mutual adjustment for all other amino acids, systolic and diastolic blood pressure. The inverse associations of isoleucine, leucine, valine, phenylalanine, threonine, tryptophan, glutamic acid, serine and tyrosine with ischaemic stroke were each attenuated with adjustment for proline intake. For haemorrhagic stroke, no statistically significant associations were observed in the continuous analyses after correcting for multiple testing.Conclusion: Higher proline intake may be associated with a lower risk of ischaemic stroke, independent of other dietary amino acids and blood pressure.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Clarke, RobertClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
  • Schmidt, Julie A.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United Kingdom; Departments of Clinical Epidemiology, Clinical Medicine, Aarhus University Hospital and Aarhus University, Aarhus, Denmark (författare)
  • Huybrechts, IngeNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France (författare)
  • Noor, UrwahCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United Kingdom (författare)
  • Forouhi, Nita G.MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Imamura, FumiakiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
  • Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United Kingdom (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France (författare)
  • Aleksandrova, KrasimiraDepartment Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Grazer Straße 2, Bremen, Germany,Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH (författare)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • van der Schouw, Yvonne T.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
  • Overvad, KimDepartment of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Kyrø, CecilieDanish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Schiborn, CatarinaDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany (författare)
  • Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute for Nutritional Science, University of Potsdam, Nuthetal, Germany (författare)
  • Mayen-Chacon, Ana-LuciaNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization (WHO), Lyon, France (författare)
  • Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (författare)
  • Sieri, SabinaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di Milano, Milan, Italy,University of Cambridge (författare)
  • de Magistris, Maria SantucciAzienda Ospedaliera Universitaria Federico II, Naples, Italy (författare)
  • Tumino, RosarioHyblean Association for Epidemiological Research AIRE-ONLUS, Ragusa, Italy (författare)
  • Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy (författare)
  • Boer, Jolanda M. A.National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM) (författare)
  • Verschuren, W. M. MoniqueJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM) (författare)
  • Brustad, MagrittDepartment of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway; The Public Dental Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway (författare)
  • Nøst, Therese HaugdahlDepartment of Community Medicine, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway (författare)
  • Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University (författare)
  • Petrova, DafinaEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP) (författare)
  • Amiano, PilarCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Huerta, José MaríaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Moreno-Iribas, ConchiCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, SpainInstituto de Salud Pu´Blica de Navarra, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome (författare)
  • Johansson, KristinaUmeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)krjo0003 (författare)
  • Lindvall, Kristina,1981-Umeå University,Umeå universitet,Institutionen för epidemiologi och global hälsa(Swepub:umu)kralil01 (författare)
  • Aglago, Elom K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Butterworth, Adam S.British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, University of Cambridge, Hills Road, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom (författare)
  • Danesh, JohnBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, University of Cambridge, Hills Road, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom,Wellcome Trust Sanger Institute (författare)
  • Key, Timothy J.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United Kingdom (författare)
  • Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, United KingdomClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nutrition: Springer Nature63, s. 209-2201436-62071436-6215

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