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Validation of a gen...
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Su, Yu-RuBiostatistics Unit, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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American association for cancer research,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-205931
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205931URI
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https://doi.org/10.1158/1055-9965.EPI-22-0817DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152807912URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer screening. A critical step towards clinical implementation is rigorous external validations in large community-based cohorts. This study externally validated a PRS-enhanced colorectal cancer risk model comprising 140 known colorectal cancer loci to provide a comprehensive assessment on prediction performance.METHODS: The model was developed using 20,338 individuals and externally validated in a community-based cohort (n = 85,221). We validated predicted 5-year absolute colorectal cancer risk, including calibration using expected-to-observed case ratios (E/O) and calibration plots, and discriminatory accuracy using time-dependent AUC. The PRS-related improvement in AUC, sensitivity and specificity were assessed in individuals of age 45 to 74 years (screening-eligible age group) and 40 to 49 years with no endoscopy history (younger-age group).RESULTS: In European-ancestral individuals, the predicted 5-year risk calibrated well [E/O = 1.01; 95% confidence interval (CI), 0.91-1.13] and had high discriminatory accuracy (AUC = 0.73; 95% CI, 0.71-0.76). Adding the PRS to a model with age, sex, family and endoscopy history improved the 5-year AUC by 0.06 (P < 0.001) and 0.14 (P = 0.05) in the screening-eligible age and younger-age groups, respectively. Using a risk-threshold of 5-year SEER colorectal cancer incidence rate at age 50 years, adding the PRS had a similar sensitivity but improved the specificity by 11% (P < 0.001) in the screening-eligible age group. In the younger-age group it improved the sensitivity by 27% (P = 0.04) with similar specificity.CONCLUSIONS: The proposed PRS-enhanced model provides a well-calibrated 5-year colorectal cancer risk prediction and improves discriminatory accuracy in the external cohort.IMPACT: The proposed model has potential utility in risk-stratified colorectal cancer prevention.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sakoda, Lori C.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, CA, Pasadena, United States
(författare)
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Jeon, JihyounDepartment of Epidemiology, University of Michigan, MI, Ann Arbor, United States
(författare)
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Thomas, MintaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Schneider, Jennifer L.Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
(författare)
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Udaltsova, NataliaDivision of Research, Kaiser Permanente Northern California, CA, Oakland, United States
(författare)
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Lee, Jeffrey K.Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, CA, San Francisco, United States
(författare)
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Lansdorp-Vogelaar, IrisDepartment of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands
(författare)
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Peterse, Elisabeth F PDepartment of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands
(författare)
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Zauber, Ann G.Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States
(författare)
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Zheng, JiayinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Zheng, YingyePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Hauser, ElizabethVA Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Health Care System, NC, Durham, United States
(författare)
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Baron, John A.Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States
(författare)
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Barry, Elizabeth L.Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
(författare)
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Bishop, D TimothyLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
(författare)
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Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Buchanan, Daniel D.Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia
(författare)
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Burnett-Hartman, AndreaInstitute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
(författare)
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Campbell, Peter T.Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia
(författare)
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Casey, GrahamCenter for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
(författare)
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Castellví-Bel, SergiGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
(författare)
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Chan, Andrew T.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
(författare)
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Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Figueiredo, Jane C.Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
(författare)
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Gallinger, Steven J.Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
(författare)
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Giles, Graham G.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
(författare)
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Gruber, Stephen B.Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
(författare)
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Gsur, AndreaInstitute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
(författare)
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Gunter, Marc J.Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Hampe, JochenDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
(författare)
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Hampel, HeatherDivision of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
(författare)
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Harrison, Tabitha A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Hoffmeister, MichaelDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Hua, XinweiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Huyghe, Jeroen R.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Jenkins, Mark A.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
(författare)
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Keku, Temitope O.Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
(författare)
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Marchand, Loic LeUniversity of Hawaii Cancer Center, HI, Honolulu, United States
(författare)
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Li, LiDepartment of Family Medicine, University of Virginia, VA, Charlottesville, United States
(författare)
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Lindblom, AnnikaKarolinska Institutet
(författare)
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Moreno, VictorOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
(författare)
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Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Pharoah, Paul D PDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
(författare)
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Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
(författare)
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Potter, John D.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Qu, ConghuiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Rennert, GadDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
(författare)
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Schoen, Robert E.Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
(författare)
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Slattery, Martha L.Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
(författare)
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Song, MingyangClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
(författare)
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van Duijnhoven, Fränzel J BDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
(författare)
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van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99
(författare)
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Vodicka, PavelDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Biomedical Center, Faculty of Medicine Pilsen, Charles University, Prague, Czech Republic
(författare)
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Wolk, AlicjaKarolinska Institutet
(författare)
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Woods, Michael O.Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
(författare)
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Wu, Anna H.Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
(författare)
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Hayes, Richard B.Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, United States
(författare)
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Peters, UlrikePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Corley, Douglas A.Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
(författare)
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Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, CA, Pasadena, United States
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Epidemiology, Biomarkers and Prevention: American association for cancer research32:3, s. 353-3621055-99651538-7755
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Su, Yu-Ru
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Sakoda, Lori C.
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Jeon, Jihyoun
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Thomas, Minta
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Lin, Yi
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Schneider, Jenni ...
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visa fler...
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Udaltsova, Natal ...
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Lee, Jeffrey K.
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Lansdorp-Vogelaa ...
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Peterse, Elisabe ...
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Zauber, Ann G.
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Zheng, Jiayin
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Zheng, Yingye
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Hauser, Elizabet ...
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Baron, John A.
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Barry, Elizabeth ...
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Bishop, D Timoth ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Burnett-Hartman, ...
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Campbell, Peter ...
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Casey, Graham
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Castellví-Bel, S ...
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Chan, Andrew T.
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Chang-Claude, Je ...
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gruber, Stephen ...
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Gsur, Andrea
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Gunter, Marc J.
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Hampe, Jochen
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Hampel, Heather
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Harrison, Tabith ...
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Hoffmeister, Mic ...
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Hua, Xinwei
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Huyghe, Jeroen R ...
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Jenkins, Mark A.
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Keku, Temitope O ...
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Marchand, Loic L ...
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Li, Li
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Lindblom, Annika
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Moreno, Victor
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Newcomb, Polly A ...
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Pharoah, Paul D ...
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Platz, Elizabeth ...
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Potter, John D.
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Qu, Conghui
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Rennert, Gad
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Schoen, Robert E ...
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Slattery, Martha ...
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Song, Mingyang
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Vodicka, Pavel
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Peters, Ulrike
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Corley, Douglas ...
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Hsu, Li
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