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Going around the Ko...
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Bhowmick, AsmitMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
Going around the Kok cycle of the water oxidation reaction with femtosecond X-ray crystallography
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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International Union Of Crystallography,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-217019
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217019URI
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https://doi.org/10.1107/S2052252523008928DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-224259URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-517409URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
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The water oxidation reaction in photosystem II (PS II) produces most of the molecular oxygen in the atmosphere, which sustains life on Earth, and in this process releases four electrons and four protons that drive the downstream process of CO2 fixation in the photosynthetic apparatus. The catalytic center of PS II is an oxygen-bridged Mn4Ca complex (Mn4CaO5) which is progressively oxidized upon the absorption of light by the chlorophyll of the PS II reaction center, and the accumulation of four oxidative equivalents in the catalytic center results in the oxidation of two waters to dioxygen in the last step. The recent emergence of X-ray free-electron lasers (XFELs) with intense femtosecond X-ray pulses has opened up opportunities to visualize this reaction in PS II as it proceeds through the catalytic cycle. In this review, we summarize our recent studies of the catalytic reaction in PS II by following the structural changes along the reaction pathway via room-temperature X-ray crystallography using XFELs. The evolution of the electron density changes at the Mn complex reveals notable structural changes, including the insertion of OX from a new water molecule, which disappears on completion of the reaction, implicating it in the O-O bond formation reaction. We were also able to follow the structural dynamics of the protein coordinating with the catalytic complex and of channels within the protein that are important for substrate and product transport, revealing well orchestrated conformational changes in response to the electronic changes at the Mn4Ca cluster.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Simon, Philipp S.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Bogacz, IsabelMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Hussein, RanaDepartment of Biology, Humboldt-Universität zu Berlin, Berlin, Germany
(författare)
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Zhang, MiaoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Makita, HirokiMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Ibrahim, MohamedDepartment of Biology, Humboldt-Universität zu Berlin, Berlin, Germany
(författare)
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Chatterjee, RuchiraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Doyle, Margaret D.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Cheah, Mun HonUppsala universitet,Molekylär biomimetik(Swepub:uu)munch343
(författare)
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Chernev, PetkoUppsala universitet,Molekylär biomimetik(Swepub:uu)petch350
(författare)
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Fuller, Franklin D.Linac Coherent Light Source, SLAC National Accelerator Laboratory, CA, Menlo Park, United States
(författare)
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Fransson, ThomasStockholms universitet,Fysikum(Swepub:su)thfr4731
(författare)
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Alonso-Mori, RobertoLinac Coherent Light Source, SLAC National Accelerator Laboratory, CA, Menlo Park, United States
(författare)
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Brewster, Aaron S.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Sauter, Nicolas K.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Bergmann, UweDepartment of Physics, University of Wisconsin-Madison, WI, Madison, United States
(författare)
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Dobbek, HolgerDepartment of Biology, Humboldt-Universität zu Berlin, Berlin, Germany
(författare)
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Zouni, AthinaDepartment of Biology, Humboldt-Universität zu Berlin, Berlin, Germany
(författare)
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Messinger, Johannes,1963-Uppsala universitet,Umeå universitet,Kemiska institutionen,Molecular Biomimetics, Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden,Molekylär biomimetik,Department of Chemistry, Umeå University, Umeå SE 90187, Sweden(Swepub:uu)johme269
(författare)
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Kern, JanMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Yachandra, Vittal K.Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Yano, JunkoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United States
(författare)
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Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, CA, Berkeley, United StatesDepartment of Biology, Humboldt-Universität zu Berlin, Berlin, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:IUCrJ: International Union Of Crystallography10:6, s. 642-6552052-2525
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Bhowmick, Asmit
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Simon, Philipp S ...
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Bogacz, Isabel
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Hussein, Rana
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Zhang, Miao
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Makita, Hiroki
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visa fler...
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Ibrahim, Mohamed
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Chatterjee, Ruch ...
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Doyle, Margaret ...
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Cheah, Mun Hon
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Chernev, Petko
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Fuller, Franklin ...
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Fransson, Thomas
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Alonso-Mori, Rob ...
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Brewster, Aaron ...
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Sauter, Nicolas ...
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Bergmann, Uwe
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Dobbek, Holger
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Zouni, Athina
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Messinger, Johan ...
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Kern, Jan
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Yachandra, Vitta ...
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Yano, Junko
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