SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Cong J)
 

Search: WFRF:(Cong J) > Accelerometer-measu...

  • Han, XiaoleiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)

Accelerometer-measured sedentary behavior patterns, brain structure, and cognitive function in dementia-free older adults : a population-based study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • IOS Press,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-217213
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217213URI
  • https://doi.org/10.3233/JAD-230575DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-224599URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154290663URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Sedentary behavior is associated with cognitive impairment, but the neuropathological mechanisms underlying their associations are poorly understood.Objective: To investigate the associations of accelerometer-measured sedentary behavior patterns with brain structure and cognition, and further to explore the potential mechanisms.Methods: This community-based study included 2,019 older adults (age≥60 years, 59% women) without dementia derived from participants in the baseline examination of MIND-China (2018-2020). We assessed sedentary parameters using an accelerometer and cognitive function using a neuropsychological test battery. Structural brain markers were assessed on the structural brain MRI scans in a subsample (n = 1,009). Data were analyzed using the general linear, isotemporal substitution, and mediation models.Results: In the total sample (n = 2,019), adjusting for multiple covariates and moderate-to-vigorous-intensity physical activity, longer mean sedentary bout duration was linearly related with lower z-scores of global cognition, verbal fluency, and memory (ptrend < 0.05), whereas greater total sedentary time was linearly associated with lower z-scores of global cognition, verbal fluency, and memory only among individuals with long sedentary time (>10 h/day) (ptrend < 0.05); Breaking up sedentary time with same amount of light-intensity physical activity was significantly associated with higher verbal fluency and memory z-scores (p < 0.05). In the MRI subsample (n = 1,009), separately entering structural brain MRI markers into the mediation models substantially attenuated the associations of mean sedentary bout duration with global cognition, verbal fluency, and memory z-scores.Conclusion: Prolonged uninterrupted sedentary time is associated with poor global cognition, memory, and verbal fluency among rural older adults, and structural brain markers could partially mediate the association.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Song, LinDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Li, YuanjingStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Dong, YiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Liu, RuiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Han, QiDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Wang, XiaojieDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Mao, MingDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Cong, LinDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Tang, ShiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Hou, TingtingDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Zhang, QinghuaDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Liu, CuicuiKarolinska Institutet (author)
  • Han, XiaodongDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Shi, LinBrainNow Research Institute, Shenzhen, Guangdong, China; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong (author)
  • Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi(Swepub:umu)lany0001 (author)
  • Launer, Lenore J.Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States (author)
  • Wang, YongxiangStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China (author)
  • Du, YifengDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (author)
  • Qiu, ChengxuanStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China (author)
  • Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:Journal of Alzheimer's Disease: IOS Press96:2, s. 657-6681387-28771875-8908

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view