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Accelerometer-measu...
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Han, XiaoleiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
Accelerometer-measured sedentary behavior patterns, brain structure, and cognitive function in dementia-free older adults : a population-based study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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IOS Press,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-217213
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217213URI
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https://doi.org/10.3233/JAD-230575DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-224599URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154290663URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Sedentary behavior is associated with cognitive impairment, but the neuropathological mechanisms underlying their associations are poorly understood.Objective: To investigate the associations of accelerometer-measured sedentary behavior patterns with brain structure and cognition, and further to explore the potential mechanisms.Methods: This community-based study included 2,019 older adults (age≥60 years, 59% women) without dementia derived from participants in the baseline examination of MIND-China (2018-2020). We assessed sedentary parameters using an accelerometer and cognitive function using a neuropsychological test battery. Structural brain markers were assessed on the structural brain MRI scans in a subsample (n = 1,009). Data were analyzed using the general linear, isotemporal substitution, and mediation models.Results: In the total sample (n = 2,019), adjusting for multiple covariates and moderate-to-vigorous-intensity physical activity, longer mean sedentary bout duration was linearly related with lower z-scores of global cognition, verbal fluency, and memory (ptrend < 0.05), whereas greater total sedentary time was linearly associated with lower z-scores of global cognition, verbal fluency, and memory only among individuals with long sedentary time (>10 h/day) (ptrend < 0.05); Breaking up sedentary time with same amount of light-intensity physical activity was significantly associated with higher verbal fluency and memory z-scores (p < 0.05). In the MRI subsample (n = 1,009), separately entering structural brain MRI markers into the mediation models substantially attenuated the associations of mean sedentary bout duration with global cognition, verbal fluency, and memory z-scores.Conclusion: Prolonged uninterrupted sedentary time is associated with poor global cognition, memory, and verbal fluency among rural older adults, and structural brain markers could partially mediate the association.
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Song, LinDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Li, YuanjingStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Dong, YiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Liu, RuiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Han, QiDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Wang, XiaojieDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Mao, MingDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Cong, LinDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Tang, ShiDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Hou, TingtingDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Zhang, QinghuaDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Liu, CuicuiKarolinska Institutet
(author)
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Han, XiaodongDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Shi, LinBrainNow Research Institute, Shenzhen, Guangdong, China; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
(author)
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi(Swepub:umu)lany0001
(author)
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Launer, Lenore J.Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
(author)
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Wang, YongxiangStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
(author)
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Du, YifengDepartment of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
(author)
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Qiu, ChengxuanStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
(author)
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Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
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In:Journal of Alzheimer's Disease: IOS Press96:2, s. 657-6681387-28771875-8908
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Han, Xiaolei
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Song, Lin
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Li, Yuanjing
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Dong, Yi
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Liu, Rui
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Han, Qi
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Wang, Xiaojie
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Mao, Ming
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Cong, Lin
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Tang, Shi
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Hou, Tingting
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Zhang, Qinghua
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Liu, Cuicui
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Han, Xiaodong
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Shi, Lin
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Nyberg, Lars, 19 ...
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Launer, Lenore J ...
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Wang, Yongxiang
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Du, Yifeng
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Qiu, Chengxuan
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