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Prediagnostic selen...
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Hughes, David J.Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
(author)
Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-217407
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217407URI
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https://doi.org/10.1016/j.freeradbiomed.2023.10.401DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Selenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3), in matched BC case-control pairs (2208 for SELENOP; 1785 for GPX3 and Se) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Single nucleotide polymorphisms (SNPs, n = 452) in 55 selenoprotein and Se metabolic pathway genes and an additional 18 variants previously associated with Se concentrations were extracted from existing genotyping data within EPIC for 1564 case-control pairs. Multivariable-adjusted logistic regression models were used to calculate the odds ratios (ORs) and 95 % confidence intervals (CIs) of the association between Se status markers, SNP variants and BC risk. Overall, there was no statistically significant association of Se status with BC risk. However, higher GPX3 activity was associated with lower risk of premenopausal BC (4th versus 1st quartile, OR = 0.54, 95 % CI: 0.30–0.98, Ptrend = 0.013). While none of the genetic variant associations (P ≤ 0.05) retained significance after multiple testing correction, rs1004243 in the SELENOM selenoprotein gene and two SNPs in the related antioxidant TXN2 gene (rs4821494 and rs5750261) were associated with respective lower and higher risks of BC at a significance threshold of P ≤ 0.01. Fourteen SNPs in twelve Se pathway genes (P ≤ 0.01) in interaction with Se status were also associated with BC risk. Higher Se status does not appear to be associated with BC risk, although activity of the selenoenzyme GPX3 may be inversely associated with premenopausal BC risk, and SNPs in the Se pathway alone or in combination with suboptimal Se status may influence BC risk.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Schomburg, LutzInstitute for Experimental Endocrinology, Charité – Medical University, Berlin, Germany
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Jenab, MazdaInternational Agency for Research on Cancer (IARC-WHO), Lyon, France
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Biessy, CarineInternational Agency for Research on Cancer (IARC-WHO), Lyon, France
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Méplan, CatherineSchool of Biomedical, Nutritional and Sport Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom
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Moskal, AurelieInternational Agency for Research on Cancer (IARC-WHO), Lyon, France; Research on Healthcare Performance (RESHAPE), INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France
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Sun, QianInstitute for Experimental Endocrinology, Charité – Medical University, Berlin, Germany
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Demircan, KamilInstitute for Experimental Endocrinology, Charité – Medical University, Berlin, Germany
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Fedirko, VeronikaDepartment of Epidemiology, MD Anderson Cancer Centre, TX, Houston, United States
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Weiderpass, ElisabeteInternational Agency for Research on Cancer (IARC-WHO), Lyon, France
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Mukhtar, MaryamCancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
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Olsen, AnjaDiet, Genes, and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; Institute of Public Health, Aarhus University, Aarhus, Denmark
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Tjønneland, AnneDiet, Genes, and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark; Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
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Overvad, KimDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
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Schulze, MatthiasDepartment of Molecular Epidemiology, German Institute of Human Nutrition, Nuthetal, Germany
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Nøst, Therese HaugdahlDepartment of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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Skeie, GuriDepartment of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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Olsen, Karina StandahlDepartment of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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Ricceri, FulvioDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, TO, Grugliasco, Italy
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Grioni, SaraEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milano, Italy
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Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Tumino, RosarioHyblean Association for Epidemiological Research, AIRE ONLUS Ragusa, Italy
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Pasanisi, FabrizioDepartiment Di Medicina Clinica E Chirurgia Federico Ii University, Naples, Italy
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Amiano, PilarMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
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Colorado Yohar, Sandra M.Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
(author)
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Agudo, AntonioUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Spain; Nutrition and Cancer Group, Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Spain
(author)
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Sánchez, Maria-JoseCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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Ardanaz, EvaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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Sund, MalinUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021
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Andersson, Anne,1966-Umeå universitet,Onkologi(Swepub:umu)ankr0012
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Perez-Cornago, AuroraCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Travis, RuthCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Dossus, LaureInternational Agency for Research on Cancer (IARC-WHO), Lyon, France
(author)
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Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, IrelandInstitute for Experimental Endocrinology, Charité – Medical University, Berlin, Germany
(creator_code:org_t)
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In:Free Radical Biology & Medicine: Elsevier209, s. 381-3930891-58491873-4596
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- By the author/editor
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Hughes, David J.
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Schomburg, Lutz
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Jenab, Mazda
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Biessy, Carine
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Méplan, Catherin ...
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Moskal, Aurelie
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Sun, Qian
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Demircan, Kamil
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Fedirko, Veronik ...
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Weiderpass, Elis ...
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Mukhtar, Maryam
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Olsen, Anja
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Tjønneland, Anne
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Overvad, Kim
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Schulze, Matthia ...
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Nøst, Therese Ha ...
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Skeie, Guri
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Olsen, Karina St ...
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Ricceri, Fulvio
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Grioni, Sara
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Palli, Domenico
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Masala, Giovanna
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Tumino, Rosario
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Pasanisi, Fabriz ...
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Amiano, Pilar
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Colorado Yohar, ...
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Agudo, Antonio
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Sánchez, Maria-J ...
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Ardanaz, Eva
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Sund, Malin
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Andersson, Anne, ...
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Perez-Cornago, A ...
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Travis, Ruth
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Heath, Alicia K.
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Dossus, Laure
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