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Estimating the Popu...
Estimating the Population Benefits of Blood Pressure Lowering : A Wide-Angled Mendelian Randomization Study in UK Biobank
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- Higgins, Hannah (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, 2 Worts Causeway, Cambridge CB1 8RN, England.
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- Mason, Amy M. (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, 2 Worts Causeway, Cambridge CB1 8RN, England.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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- Gill, Dipender (författare)
- Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Novo Nordisk Res Ctr Oxford, Dept Genet, Oxford, England.;St Georges Univ London, Clin Pharmacol & Therapeut Sect, Inst Med & Biomed Educ, London, England.;St Georges Univ London, Inst Infect & Immun, London, England.;St Georges Univ Hosp Natl Hlth Serv Fdn Trust, Clin Pharmacol Grp, Pharm & Med Directorate, London, England.
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- Langenberg, Claudia (författare)
- Univ Cambridge, Epidemiol Unit, Med Res Council, Cambridge, England.;Berlin Inst Hlth, Computat Med, Berlin, Germany.;Charite, Berlin, Germany.
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- Burgess, Stephen (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, 2 Worts Causeway, Cambridge CB1 8RN, England.;Univ Cambridge, Biostat Unit, Med Res Council, Cambridge, England.
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Univ Cambridge, Dept Publ Hlth & Primary Care, 2 Worts Causeway, Cambridge CB1 8RN, England Medicinsk epidemiologi (creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- Engelska.
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Ingår i: Journal of the American Heart Association. - : Wolters Kluwer. - 2047-9980. ; 10:17
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BackgroundThe causal relevance of elevated blood pressure for several cardiovascular diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This study systematically assesses evidence of causality for various CVDs in a 2‐sample Mendelian randomization framework, and estimates the potential reduction in the prevalence of these diseases attributable to long‐term population shifts in the distribution of systolic blood pressure (SBP).Methods and ResultsWe investigated associations of genetically predicted SBP as predicted by 256 genetic variants with 21 CVDs in UK Biobank, a population‐based cohort of UK residents. The sample consisted of 376 703 participants of European ancestry, aged 40 to 69 years at recruitment. Genetically predicted SBP was positively associated with 14 of the outcomes (P<0.002), including dilated cardiomyopathy, endocarditis, peripheral vascular disease, and rheumatic heart disease. Using genetic variation to estimate the long‐term impact of blood pressure lowering on disease in a middle‐aged to early late‐aged UK‐based population, population reductions in SBP were predicted to result in an overall 16.9% (95% CI, 12.2%–21.3%) decrease in morbidity for a 5–mm Hg decrease from a population mean of 137.7 mm Hg, 30.8% (95% CI, 22.8%–38.0%) decrease for a 10–mm Hg decrease, and 56.2% (95% CI, 43.7%–65.9%) decrease for a 22.7–mm Hg decrease in SBP (22.7 mm Hg represents a shift from the current mean SBP to 115 mm Hg).ConclusionsRisk of many CVDs is influenced by long‐term differences in SBP. The burden of a broad range of CVDs could be substantially reduced by long‐term population‐wide reductions in the distribution of blood pressure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- genetic epidemiology
- high blood pressure
- hypertension
- Mendelian randomization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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