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  • Zhao, XiaoyuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Statistics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (författare)

Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-217717
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217717URI
  • https://doi.org/10.1002/cncr.35130DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Although the associations between genetic variations and lung cancer risk have been explored, the epigenetic consequences of DNA methylation in lung cancer development are largely unknown. Here, the genetically predicted DNA methylation markers associated with non–small cell lung cancer (NSCLC) risk by a two-stage case-control design were investigated.Methods: The genetic prediction models for methylation levels based on genetic and methylation data of 1595 subjects from the Framingham Heart Study were established. The prediction models were applied to a fixed-effect meta-analysis of screening data sets with 27,120 NSCLC cases and 27,355 controls to identify the methylation markers, which were then replicated in independent data sets with 7844 lung cancer cases and 421,224 controls. Also performed was a multi-omics functional annotation for the identified CpGs by integrating genomics, epigenomics, and transcriptomics and investigation of the potential regulation pathways.Results: Of the 29,894 CpG sites passing the quality control, 39 CpGs associated with NSCLC risk (Bonferroni-corrected p ≤ 1.67 × 10−6) were originally identified. Of these, 16 CpGs remained significant in the validation stage (Bonferroni-corrected p ≤ 1.28 × 10−3), including four novel CpGs. Multi-omics functional annotation showed nine of 16 CpGs were potentially functional biomarkers for NSCLC risk. Thirty-five genes within a 1-Mb window of 12 CpGs that might be involved in regulatory pathways of NSCLC risk were identified.Conclusions: Sixteen promising DNA methylation markers associated with NSCLC were identified. Changes of the methylation level at these CpGs might influence the development of NSCLC by regulating the expression of genes nearby.Plain Language Summary: The epigenetic consequences of DNA methylation in lung cancer development are still largely unknown. This study used summary data of large-scale genome-wide association studies to investigate the associations between genetically predicted levels of methylation biomarkers and non–small cell lung cancer risk at the first time. This study looked at how well larotrectinib worked in adult patients with sarcomas caused by TRK fusion proteins. These findings will provide a unique insight into the epigenetic susceptibility mechanisms of lung cancer.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yang, MeiqiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Fan, JingyiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China; Health Management Center, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China (författare)
  • Wang, MeiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Wang, YifanDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China (författare)
  • Qin, NaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Zhu, MengDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China; Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China (författare)
  • Jiang, YueDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Gorlova, Olga Y.Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, NH, Lebanon, United States; Department of Medicine, Epidemiology Section, Institute for Clinical and Translational Research, Baylor Medical College, TX, Houston, United States (författare)
  • Gorlov, Ivan P.Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, NH, Lebanon, United States; Department of Medicine, Epidemiology Section, Institute for Clinical and Translational Research, Baylor Medical College, TX, Houston, United States (författare)
  • Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States (författare)
  • Lam, StephenDepartment of Integrative Oncology, British Columbia Cancer Agency, BC, Vancouver, Canada (författare)
  • Tardón, AdoninaDepartment of Public Health IUOPA, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain (författare)
  • Chen, ChuProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Goodman, Gary E.Public Health Sciences Division, Swedish Cancer Institute, WA, Seattle, United States (författare)
  • Bojesen, Stig E.Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Landi, Maria TeresaNational Cancer Institute, MD, Bethesda, United States (författare)
  • Johansson, MattiasGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (författare)
  • Risch, AngelaDepartment of Biosciences, Allergy-Cancer-BioNano Research Centre, University of Salzburg, Salzburg, Austria; Division of Epigenomics and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany (författare)
  • Wichmann, H.-ErichInstitute of Epidemiology, Helmholtz Center Munich, Neuherberg, Germany (författare)
  • Bickeböller, HeikeDepartment of Genetic Epidemiology, University Medical Center Goettingen, Goettingen, Germany (författare)
  • Christiani, David C.Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Rennert, GadTechnion Faculty of Medicine, Carmel Medical Center, Haifa, Israel (författare)
  • Arnold, Susanne M.Markey Cancer Center, University of Kentucky, KY, Lexington, United States (författare)
  • Brennan, PaulGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France (författare)
  • Field, John K.Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool Institute of Translational Medicine, Liverpool, United Kingdom (författare)
  • Shete, SanjayDepartment of Epidemiology, The University of Texas, MD Anderson Cancer Center, TX, Houston, United States (författare)
  • Le Marchand, LoïcEpidemiology Program, University of Hawai'i Cancer Center, HI, Honolulu, United States (författare)
  • Liu, GeoffreyPrincess Margaret Cancer Centre, ON, Toronto, Canada (författare)
  • Hung, Rayjean J.Prosseman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, ON, Toronto, Canada (författare)
  • Andrew, Angeline S.Department of Neurology, Dartmouth-Hitchcock Medical Center, NH, Lebanon, United States (författare)
  • Kiemeney, Lambertus A.Department for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Zienolddiny, ShanbehNational Institute of Occupational Health (STAMI), Oslo, Norway (författare)
  • Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (författare)
  • Johansson, MikaelUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)mijo0025 (författare)
  • Caporaso, Neil E.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States (författare)
  • Woll, Penella J.Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom (författare)
  • Lazarus, PhilipDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States (författare)
  • Schabath, Matthew B.Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States (författare)
  • Aldrich, Melinda C.Department of Medicine (Division of Genetic Medicine), Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Patel, Alpa V.Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States (författare)
  • Davies, Michael P. A.Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom (författare)
  • Ma, HongxiaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Jin, GuangfuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Hu, ZhibinDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Amos, Christopher I.Baylor College of Medicine, Institute for Clinical and Translational Research, TX, Houston, United States (författare)
  • Shen, HongbingDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Dai, JunchengDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Gusu School, Nanjing Medical University, Nanjing, China (författare)
  • Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Statistics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer: John Wiley & Sons130:6, s. 913-9260008-543X1097-0142

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  • Cancer (Sök värdpublikationen i LIBRIS)

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