Global effect of modifiable risk factors on cardiovascular disease and mortality

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Prescott J) > (2020-2024) > Global effect of mo...

Details
MARC

Magnussen, ChristinaCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany (author)

Global effect of modifiable risk factors on cardiovascular disease and mortality

Article/chapterEnglish2023

Publisher, publication year, extent ...

Massachusetts Medical Society,2023
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-217718
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217718URI
https://doi.org/10.1056/NEJMoa2206916DOI
https://lup.lub.lu.se/record/bba5a231-6c1f-4eed-a0f9-b461172665b8URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Cardiology
Cardiology General
Coronary Disease/Myocardial Infarction
Diabetes
Endocrinology
Hypertension
Lipids
Obesity
Prevention
Public Health
Public Health General
Cardiovascular Diseases
Cohort Studies
Diabetes Mellitus
Female
Humans
Male
Middle Aged
Risk Factors
Smoking
high density lipoprotein cholesterol
adult
all cause mortality
Article
body mass
cardiovascular disease
cardiovascular mortality
cohort analysis
confidence interval
controlled study
current smoker
death
diabetes mellitus
female
follow up
groups by age and sex
human
incidence
major clinical study
male
middle aged
prevalence
proportional hazards model
risk factor
systolic blood pressure
treatment outcome
smoking

Added entries (persons, corporate bodies, meetings, titles ...)

Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Leong, Darryl P.Department of Medicine (Cardiology), McMaster University, Hamilton, Canada (author)
Alegre-Diaz, JesusExperimental Medicine Research Unit, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico (author)
Amouyel, PhilippeUniversité de Lille, Inserm, Centre Hospitalier University de Lille, Institut Pasteur de Lille, UMR1167 RID-AGE Risk Factors and Molecular Determinants of Aging-Related Diseases, Epidemiology and Public Health Department, Lille, France (author)
Aviles-Santa, LarissaDivision of Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, MD, Bethesda, United States (author)
De Bacquer, DirkDepartment of Public Health and Primary Care, Ghent University, Ghent, Belgium (author)
Ballantyne, Christie M.Department of Medicine, Baylor College of Medicine, TX, Houston, United States (author)
Bernabé-Ortiz, AntonioCronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru (author)
Bobak, MartinDepartment of Epidemiology and Public Health, University College London, London, United Kingdom (author)
Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany (author)
Carrillo-Larco, Rodrigo M.Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States (author)
De Lemos, JamesDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, TX, Dallas, United States (author)
Dobson, AnnetteSchool of Public Health, University of Queensland, Brisbane, Australia (author)
Dörr, MarcusDepartment of Internal Medicine B, University Medicine Greifswald, Dzhk Partner Site Greifswald, Greifswald, Germany (author)
Donfrancesco, ChiaraDepartment of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy (author)
Drygas, WojciechDepartment of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Lazarski University, Warsaw, Poland (author)
Dullaart, Robin P.Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (author)
Engström, G.Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
Ferrario, Marco M.Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy (author)
Ferrières, JeanDepartment of Cardiology, Inserm UMR1295, Toulouse Rangueil University Hospital, Toulouse, France (author)
De Gaetano, GiovanniDepartment of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy (author)
Goldbourt, UriDepartment of Epidemiology, Tel Aviv University School of Public Health, Tel Aviv, Israel (author)
Gonzalez, ClicerioCentro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico (author)
Grassi, GuidoClinica Medica, University of Milano Bicocca, Milan, Italy (author)
Hodge, Allison M.Division of Cancer Epidemiology, Cancer Council Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Australia (author)
Hveem, KristianHunt (Trøndelag Health Study) Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Trondheim, Norway (author)
Iacoviello, LiciaResearch Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy (author)
Ikram, M. KamranDepartment of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands (author)
Irazola, VilmaDepartment of Chronic Diseases, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina (author)
Jobe, ModouMedical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia (author)
Jousilahti, PekkaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (author)
Kaleebu, PontianoMedical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda (author)
Kavousi, MaryamDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands (author)
Kee, FrankThe Centre for Public Health, Queens University Belfast, Belfast, United Kingdom (author)
Khalili, DavoodPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran (author)
Koenig, WolfgangDzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; German Heart Center, Technical University of Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany (author)
Kontsevaya, AnnaNational Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation (author)
Kuulasmaa, KariDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (author)
Lackner, Karl J.Institute of Clinical Chemistry and Laboratory Medicine, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany (author)
Leistner, David M.University Heart and Vascular Center Frankfurt, Dzhk Partner Site Rhine Main, Frankfurt, Germany (author)
Lind, LarsDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden (author)
Linneberg, AllanDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark (author)
Lorenz, ThiessCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany (author)
Lyngbakken, Magnus NakremDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway (author)
Malekzadeh, RezaLiver and Pancreaticobiliary Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (author)
Malyutina, SofiaResearch Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation (author)
Mathiesen, Ellisiv B.Department of Clinical Medicine, University of Tromsø the Arctic University of Norway, Tromsø, Norway (author)
Melander, OlleDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden (author)
Metspalu, AndresEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia (author)
Miranda, J. JaimeCronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia (author)
Moitry, MarieDepartment of Public Health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France (author)
Mugisha, JosephMedical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda (author)
Nalini, MahdiMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (author)
Nambi, VijayMichael E. DeBakey Veterans Affairs Hospital, Baylor College of Medicine, TX, Houston, United States (author)
Ninomiya, ToshiharuDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (author)
Oppermann, KarenSchool of Medicine, University of Passo Fundo, Passo Fundo, Brazil (author)
D'Orsi, EleonoraDepartment of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianopolis, Brazil (author)
Pająk, AndrzejDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland (author)
Palmieri, LuigiDepartment of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy (author)
Panagiotakos, DemosthenesSchool of Health Sciences and Education, Harokopio University, Athens, Greece (author)
Perianayagam, ArokiasamyNational Council of Applied Economic Research, Delhi, India; International Institute for Population Sciences, Mumbai, India (author)
Peters, AnnetteDzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany (author)
Poustchi, HosseinDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (author)
Prentice, Andrew M.Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia (author)
Prescott, EvaDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark (author)
Risérus, UlfDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (author)
Salomaa, VeikkoDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland (author)
Sans, SusanaCatalan Department of Health, Barcelona, Spain,University Medical Center Hamburg-Eppendorf (author)
Sakata, SatokoDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (author)
Schöttker, BenDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany (author)
Schutte, Aletta E.George Institute for Global Health, Sydney, Australia; School of Population Health, Kensington, Australia; Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa (author)
Sepanlou, Sadaf G.Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran (author)
Sharma, Sanjib KumarDepartment of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal (author)
Shaw, Jonathan E.Baker Heart and Diabetes Institute, Melbourne, Australia (author)
Simons, Leon A.University of New South Wales, Kensington, Australia (author)
Söderberg, StefanUmeå universitet,Kardiologi,Avdelningen för medicin(Swepub:umu)stso0001 (author)
Tamosiunas, AbdonasLaboratory of Population Studies, Institute of Cardiology, Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania (author)
Thorand, BarbaraInstitute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany (author)
Tunstall-Pedoe, HughCardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom (author)
Twerenbold, RaphaelCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany (author)
Vanuzzo, DiegoMonica (Monitoring Cardiovascular Diseases) Friuli Study Group, Udine, Italy (author)
Veronesi, GiovanniResearch Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy (author)
Waibel, JuliaCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany (author)
Wannamethee, S. GoyaResearch Department of Primary Care and Population Health, University College London, London, United Kingdom (author)
Watanabe, MasafumiGlobal Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan (author)
Wild, Philipp S.Preventive Cardiology and Preventive Medicine, Mainz, Germany; Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany; Institute for Molecular Biology, Mainz, Germany (author)
Yao, YaoChina Center for Health Development Studies, National School of Development, Peking University, China; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China (author)
Zeng, YiCenter for Healthy Aging and Development Studies, National School of Development, Peking University, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, NC, Durham, United States (author)
Ziegler, AndreasCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Cardio-CARE, Davos, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland (author)
Blankenberg, StefanCenter for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany; Cardio-CARE, Davos, Switzerland (author)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, GermanyKardiovaskulär forskning - hypertoni (creator_code:org_t)
et al.

Related titles

In:New England Journal of Medicine: Massachusetts Medical Society389:14, s. 1273-12850028-47931533-4406

Internet link

Find in a library

New England Journal of Medicine (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Magnussen, Chris ...; Melander, O.; Leong, Darryl P.; Alegre-Diaz, Jes ...; Amouyel, Philipp ...; Aviles-Santa, La ...; show more...; De Bacquer, Dirk; Ballantyne, Chri ...; Bernabé-Ortiz, A ...; Bobak, Martin; Brenner, Hermann; Carrillo-Larco, ...; De Lemos, James; Dobson, Annette; Dörr, Marcus; Donfrancesco, Ch ...; Drygas, Wojciech; Dullaart, Robin ...; Engström, G.; Ferrario, Marco ...; Ferrières, Jean; De Gaetano, Giov ...; Goldbourt, Uri; Gonzalez, Clicer ...; Grassi, Guido; Hodge, Allison M ...; Hveem, Kristian; Iacoviello, Lici ...; Ikram, M. Kamran; Irazola, Vilma; Jobe, Modou; Jousilahti, Pekk ...; Kaleebu, Pontian ...; Kavousi, Maryam; Kee, Frank; Khalili, Davood; Koenig, Wolfgang; Kontsevaya, Anna; Kuulasmaa, Kari; Lackner, Karl J.; Leistner, David ...; Lind, Lars; Linneberg, Allan; Lorenz, Thiess; Lyngbakken, Magn ...; Malekzadeh, Reza; Malyutina, Sofia; Mathiesen, Ellis ...; Melander, Olle; Metspalu, Andres; Miranda, J. Jaim ...; Moitry, Marie; Mugisha, Joseph; Nalini, Mahdi; Nambi, Vijay; Ninomiya, Toshih ...; Oppermann, Karen; D'Orsi, Eleonora; Pająk, Andrzej; Palmieri, Luigi; Panagiotakos, De ...; Perianayagam, Ar ...; Peters, Annette; Poustchi, Hossei ...; Prentice, Andrew ...; Prescott, Eva; Risérus, Ulf; Salomaa, Veikko; Sans, Susana; Sakata, Satoko; Schöttker, Ben; Schutte, Aletta ...; Sepanlou, Sadaf ...; Sharma, Sanjib K ...; Shaw, Jonathan E ...; Simons, Leon A.; Söderberg, Stefa ...; Tamosiunas, Abdo ...; Thorand, Barbara; Tunstall-Pedoe, ...; Twerenbold, Raph ...; Vanuzzo, Diego; Veronesi, Giovan ...; Waibel, Julia; Wannamethee, S. ...; Watanabe, Masafu ...; Wild, Philipp S.; Yao, Yao; Zeng, Yi; Ziegler, Andreas; Blankenberg, Ste ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: New England Jour ...

By the university: Umeå University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se