Sökning: WFRF:(Kievit Rogier) >
No phenotypic or ge...
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Fjell, Anders M.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
(författare)
No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Springer Nature,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-217882
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217882URI
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https://doi.org/10.1038/s41562-023-01707-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration—which is shorter than current recommendations.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sørensen, ØysteinCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(författare)
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Wang, YunpengCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(författare)
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Amlien, Inge K.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(författare)
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Baaré, William F. C.Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital—Amager and Hvidovre, Copenhagen, Denmark
(författare)
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Bartrés-Faz, DavidDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; Institut d’Investigacions Biomèdiques August Pii Sunyer, Barcelona, Spain
(författare)
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Bertram, LarsCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany
(författare)
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Boraxbekk, Carl-Johan,1980-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital—Amager and Hvidovre, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark(Swepub:umu)olncan02
(författare)
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Brandmaier, Andreas M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, Germany
(författare)
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Demuth, IljaDepartment of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Biology of Aging Working Group, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Berlin, Germany
(författare)
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Drevon, Christian A.Vitas AS, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Ebmeier, Klaus P.Department of Psychiatry, University of Oxford, Oxford, United Kingdom
(författare)
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Ghisletta, PaoloFaculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; UniDistance Suisse, Brig, Switzerland; Swiss National Centre of Competence in Research LIVES, University of Geneva, Geneva, Switzerland
(författare)
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Kievit, RogierCognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands
(författare)
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Kühn, SimoneCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(författare)
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Madsen, Kathrine SkakDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital—Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
(författare)
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Mowinckel, Athanasia M.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(författare)
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Nyberg, Lars,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway(Swepub:umu)lany0001
(författare)
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Sexton, Claire E.Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Global Brain Health Institute, Department of Neurology, University of California, San Francisco, CA, San Francisco, United States; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom; Alzheimer’s Association, IL, Chicago, United States
(författare)
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Solé-Padullés, CristinaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; Institut d’Investigacions Biomèdiques August Pii Sunyer, Barcelona, Spain
(författare)
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Vidal-Piñeiro, DidacCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(författare)
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Wagner, GerdDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
(författare)
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Watne, Leiv OttoOslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, Oslo, Norway; Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway
(författare)
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Walhovd, Kristine B.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
(författare)
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Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayCenter for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Human Behaviour: Springer Nature7:11, s. 2008-20222397-3374
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Fjell, Anders M.
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Sørensen, Øystei ...
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Wang, Yunpeng
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Amlien, Inge K.
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Baaré, William F ...
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Bartrés-Faz, Dav ...
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visa fler...
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Bertram, Lars
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Boraxbekk, Carl- ...
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Brandmaier, Andr ...
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Demuth, Ilja
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Drevon, Christia ...
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Ebmeier, Klaus P ...
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Ghisletta, Paolo
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Kievit, Rogier
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Kühn, Simone
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Madsen, Kathrine ...
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Sexton, Claire E ...
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Solé-Padullés, C ...
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Vidal-Piñeiro, D ...
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Wagner, Gerd
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Watne, Leiv Otto
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Walhovd, Kristin ...
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