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Observational and g...
Observational and genetic associations between cardiorespiratory fitness and cancer : a UK Biobank and international consortia study
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- Watts, Eleanor L. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Gonzales, Tomas I. (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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- Strain, Tessa (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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show more...
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- Saint-Maurice, Pedro F. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Bishop, D. Timothy (author)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Chanock, Stephen J. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Johansson, Mattias (author)
- Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Keku, Temitope O. (author)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
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- Le Marchand, Loic (author)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Moreno, Victor (author)
- Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and University of Barcelona Institute for Complex Systems (UBICS), University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
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- Newcomb, Polly A. (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
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- Newton, Christina C. (author)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Pai, Rish K. (author)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
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- Purdue, Mark P. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Ulrich, Cornelia M. (author)
- Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Smith-Byrne, Karl (author)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- van Guelpen, Bethany (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Eeles, Rosalind A. (author)
- The Institute of Cancer Research, London, United Kingdom; Royal Marsden NHS Foundation Trust, London, United Kingdom
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- Haiman, Christopher A. (author)
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States
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- Kote-Jarai, Zsofia (author)
- The Institute of Cancer Research, London, United Kingdom
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- Schumacher, Fredrick R. (author)
- Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Seidman Cancer Center, University Hospitals, OH, Cleveland, United States
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- Benlloch, Sara (author)
- The Institute of Cancer Research, London, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
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- Olama, Ali Amin Al (author)
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom; University of Cambridge, Department of Clinical Neurosciences, Stroke Research Group, R3, Box 83, Cambridge Biomedical Campus, Cambridge, United Kingdom
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- Muir, Kenneth R. (author)
- Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, United Kingdom
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- Berndt, Sonja I. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
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- Conti, David V. (author)
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States
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- Wiklund, Fredrik (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
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- Chanock, Stephen J. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
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- Wang, Ying (author)
- Department of Population Science, American Cancer Society, 250 Williams Street, GA, Atlanta, United States
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- Tangen, Catherine M. (author)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Batra, Jyotsna (author)
- Translational Research Institute, QLD, Brisbane, Australia; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, QLD, Brisbane, Australia
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- Clements, Judith A. (author)
- Translational Research Institute, QLD, Brisbane, Australia; Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, QLD, Brisbane, Australia
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- Grönberg, Henrik (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
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- Pashayan, Nora (author)
- Department of Applied Health Research, University College London, London, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, United Kingdom
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- Schleutker, Johanna (author)
- Institute of Biomedicine, University of Turku, Turku, Finland; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, PO Box 52, Turku, Finland
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- Albanes, Demetrius (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Weinstein, Stephanie J. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Wolk, Alicja (author)
- Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- West, Catharine M. L. (author)
- Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
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- Mucci, Lorelei A. (author)
- Department of Epidemiology, Harvard T. H. Chan School of Public Health, MA, Boston, United States
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- Cancel-Tassin, Géraldine (author)
- CeRePP, Tenon Hospital, Paris, France; Sorbonne Universite, GRC n° 5, AP-HP, Tenon Hospital, 4 rue de la Chine, Paris, France
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- Koutros, Stella (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Sørensen, Karina Dalsgaard (author)
- Department of Molecular Medicine, Aarhus University Hospital, Palle Juul-Jensen Boulevard 99, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark
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- Grindedal, Eli Marie (author)
- Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
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- Neal, David E. (author)
- Nuffield Department of Surgical Sciences, University of Oxford, Room 6603, Level 6, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom; University of Cambridge, Department of Oncology, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge, United Kingdom; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
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- Hamdy, Freddie C. (author)
- Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
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- Donovan, Jenny L. (author)
- Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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- Travis, Ruth C. (author)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Hamilton, Robert J. (author)
- Department. of Surgical Oncology, Princess Margaret Cancer Centre, ON, Toronto, Canada; Department. of Surgery (Urology), University of Toronto, ON, Toronto, Canada
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- Ingles, Sue Ann (author)
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, CA, Los Angeles, United States
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- Rosenstein, Barry S. (author)
- Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Box 1236, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, NY, New York, United States
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- Lu, Yong-Jie (author)
- Centre for Cancer Biomarker and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, United Kingdom
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- Giles, Graham G. (author)
- Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Grattan Street, VIC, Parkville, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- MacInnis, Robert J. (author)
- Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Grattan Street, VIC, Parkville, Australia
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- Kibel, Adam S. (author)
- Division of Urologic Surgery, Brigham and Women’s Hospital, 75 Francis Street, MA, Boston, United States
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- Vega, Ana (author)
- Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Compostela, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Barcelona, Spain
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- Kogevinas, Manolis (author)
- ISGlobal, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Penney, Kathryn L. (author)
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, MA, Boston, United States
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- Park, Jong Y. (author)
- Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, FL, Tampa, United States
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- Stanford, Janet L. (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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- Cybulski, Cezary (author)
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
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- Nordestgaard, Børge G. (author)
- Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark
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- Nielsen, Sune F. (author)
- Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Herlev, Denmark
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- Brenner, Hermann (author)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany
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- Maier, Christiane (author)
- Humangenetik Tuebingen, Paul-Ehrlich-Str 23, Tuebingen, Germany
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- Kim, Jeri (author)
- The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, 1515 Holcombe Blvd., TX, Houston, United States
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- John, Esther M. (author)
- Departments of Epidemiology & Population Health and of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, CA, Stanford, United States
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- Teixeira, Manuel R. (author)
- Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal
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- Neuhausen, Susan L. (author)
- Department of Population Sciences, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, CA, Duarte, United States
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- De Ruyck, Kim (author)
- Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Proeftuinstraat 86, Gent, Belgium
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- Razack, Azad (author)
- Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
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- Newcomb, Lisa F. (author)
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Urology, University of Washington, 1959 NE Pacific Street, Box 356510, WA, Seattle, United States
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- Lessel, Davor (author)
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Kaneva, Radka (author)
- Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, 2 Zdrave Str, Sofia, Bulgaria
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- Usmani, Nawaid (author)
- Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, AB, Edmonton, Canada; Division of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, AB, Edmonton, Canada
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- Claessens, Frank (author)
- Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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- Townsend, Paul A. (author)
- Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, Univeristy of Manchester, Manchester, United Kingdom; The University of Surrey, Surrey, Guildford, United Kingdom
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- Castelao, Jose Esteban (author)
- Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain
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- Roobol, Monique J. (author)
- Department of Urology, Erasmus University Medical Center, Cancer Institute, Rotterdam, Netherlands
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- Menegaux, Florence (author)
- “Exposome and Heredity”, CESP (UMR 1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France
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- Khaw, Kay-Tee (author)
- Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom
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- Cannon-Albright, Lisa (author)
- Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, UT, Salt Lake City, United States; George E. Wahlen Department of Veterans Affairs Medical Center, UT, Salt Lake City, United States
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- Pandha, Hardev (author)
- The University of Surrey, Surrey, Guildford, United Kingdom
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- Thibodeau, Stephen N. (author)
- Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Hunter, David J. (author)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Kraft, Peter (author)
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, MA, Boston, United States
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- Blot, William J. (author)
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, TN, Nashville, United States; International Epidemiology Institute, MD, Rockville, United States
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- Riboli, Elio (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Day, Felix R. (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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- Wijndaele, Katrien (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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- Wareham, Nicholas J. (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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- Matthews, Charles E. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Moore, Steven C. (author)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Rockville, United States
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- Brage, Soren (author)
- MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
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In: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 130, s. 114-124
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Background: The association of fitness with cancer risk is not clear.Methods: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method.Results: After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated.Discussion: Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Watts, Eleanor L ...
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Gonzales, Tomas ...
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Strain, Tessa
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Saint-Maurice, P ...
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Bishop, D. Timot ...
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Chanock, Stephen ...
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show more...
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Johansson, Matti ...
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Keku, Temitope O ...
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Le Marchand, Loi ...
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Moreno, Victor
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Newcomb, Polly A ...
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Newton, Christin ...
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Pai, Rish K.
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Purdue, Mark P.
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Ulrich, Cornelia ...
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Smith-Byrne, Kar ...
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van Guelpen, Bet ...
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Eeles, Rosalind ...
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Haiman, Christop ...
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Kote-Jarai, Zsof ...
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Schumacher, Fred ...
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Benlloch, Sara
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Olama, Ali Amin ...
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Muir, Kenneth R.
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Berndt, Sonja I.
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Conti, David V.
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Wiklund, Fredrik
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Wang, Ying
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Tangen, Catherin ...
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Batra, Jyotsna
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Clements, Judith ...
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Grönberg, Henrik
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Pashayan, Nora
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Schleutker, Joha ...
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Albanes, Demetri ...
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Weinstein, Steph ...
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Wolk, Alicja
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West, Catharine ...
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Mucci, Lorelei A ...
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Cancel-Tassin, G ...
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Koutros, Stella
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Sørensen, Karina ...
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Grindedal, Eli M ...
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Neal, David E.
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Hamdy, Freddie C ...
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Donovan, Jenny L ...
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Travis, Ruth C.
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Hamilton, Robert ...
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Ingles, Sue Ann
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Rosenstein, Barr ...
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Lu, Yong-Jie
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Giles, Graham G.
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MacInnis, Robert ...
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Kibel, Adam S.
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Vega, Ana
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Kogevinas, Manol ...
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Penney, Kathryn ...
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Park, Jong Y.
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Stanford, Janet ...
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Cybulski, Cezary
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Nordestgaard, Bø ...
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Nielsen, Sune F.
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Brenner, Hermann
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Maier, Christian ...
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Kim, Jeri
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John, Esther M.
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Teixeira, Manuel ...
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Neuhausen, Susan ...
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De Ruyck, Kim
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Razack, Azad
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Newcomb, Lisa F.
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Lessel, Davor
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Kaneva, Radka
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Usmani, Nawaid
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Claessens, Frank
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Townsend, Paul A ...
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Castelao, Jose E ...
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Roobol, Monique ...
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Menegaux, Floren ...
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Khaw, Kay-Tee
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Cannon-Albright, ...
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Pandha, Hardev
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Thibodeau, Steph ...
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Hunter, David J.
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Kraft, Peter
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Blot, William J.
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Riboli, Elio
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Day, Felix R.
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Wijndaele, Katri ...
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Wareham, Nichola ...
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Matthews, Charle ...
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Moore, Steven C.
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Brage, Soren
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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British Journal ...
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Umeå University