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Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium.

Lophatananon, Artitaya (author)
Stewart-Brown, Sarah (author)
Kote-Jarai, Zsofia (author)
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Olama, Ali Amin Al (author)
Garcia, Sara Benlloch (author)
Neal, David E (author)
Hamdy, Freddie C (author)
Donovan, Jenny L (author)
Giles, Graham G (author)
Fitzgerald, Liesel M (author)
Southey, Melissa C (author)
Pharoah, Paul (author)
Pashayan, Nora (author)
Gronberg, Henrik (author)
Karolinska Institutet
Wiklund, Fredrik (author)
Karolinska Institutet
Aly, Markus (author)
Karolinska Institutet
Stanford, Janet L (author)
Brenner, Hermann (author)
Dieffenbach, Aida K (author)
Arndt, Volker (author)
Park, Jong Y (author)
Lin, Hui-Yi (author)
Sellers, Thomas (author)
Slavov, Chavdar (author)
Kaneva, Radka (author)
Mitev, Vanio (author)
Batra, Jyotsna (author)
Spurdle, Amanda (author)
Clements, Judith A (author)
Easton, Douglas (author)
Eeles, Rosalind A (author)
Muir, Kenneth (author)
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 (creator_code:org_t)
2017-08-01
2017
English.
In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 117:5, s. 734-743
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.CONCLUSIONS: There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

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