Management of localized small- and large-cell pancreatic neuroendocrine carcinoma in the national cancer database

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Sugawara, ToshitakaUniversity of Colorado School of Medicine, Aurora, Colorado, USA; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan (författare)

Management of localized small- and large-cell pancreatic neuroendocrine carcinoma in the national cancer database

Artikel/kapitelEngelska2023

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Wolters Kluwer,2023
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LIBRIS-ID:oai:DiVA.org:umu-218673
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218673URI
https://doi.org/10.1097/XCS.0000000000000735DOI

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Språk:engelska
Sammanfattning på:engelska

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BACKGROUND: The role of curative-intent resection and perioperative chemotherapy for nonmetastatic pancreatic neuroendocrine carcinoma (PanNEC) remains unclear due to their biological aggressiveness and rarity. This study aimed to evaluate the association of resection and perioperative chemotherapy with overall survival for nonmetastatic PanNEC.STUDY DESIGN: Patients with localized (cT1-3, M0), small- and large-cell PanNEC were identified in the National Cancer Database from 2004 to 2017. The changing trends in terms of the annual proportions of resection and adjuvant chemotherapy were assessed. The survival of patients who received resection and those who received adjuvant chemotherapy were investigated using Kaplan-Meier estimates and Cox regression models.RESULTS: In total, 199 patients with localized small- and large-cell PanNEC were identified; 50.3% of those were resected, and 45.0% of the resected patients received adjuvant chemotherapy. Rate of resection and adjuvant treatment has trended upward since 2011. The resected group was younger, was more often treated at academic institutions, had more distal tumors, and had a lower number of small-cell PanNEC. The median overall survival was longer in the resected group compared to the unresected group (29.4 months vs 8.6 months, p < 0.001). Resection was associated with improved survival in a multivariable Cox regression model adjusting for preoperative factors (adjusted hazard ratio 0.58, 95% CI 0.37 to 0.92), while adjuvant therapy was not.CONCLUSIONS: This nationwide retrospective study suggests that resection is associated with improved survival in patients with localized PanNEC. The role of adjuvant chemotherapy needs more investigation.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Rodriguez Franco, SalvadorUniversity of Colorado School of Medicine, Aurora, Colorado, USA (författare)
Franklin, Oskar,1985-Umeå universitet,Kirurgi,University of Colorado School of Medicine, Aurora, Colorado, USA(Swepub:umu)osfr0002 (författare)
Kirsch, Michael J.University of Colorado School of Medicine, Aurora, Colorado, USA (författare)
Colborn, Kathryn L.University of Colorado School of Medicine, Aurora, Colorado, USA (författare)
Del Chiaro, MarcoUniversity of Colorado School of Medicine, Aurora, Colorado, USA (författare)
Schulick, Richard D.University of Colorado School of Medicine, Aurora, Colorado, USA (författare)
University of Colorado School of Medicine, Aurora, Colorado, USA; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, JapanUniversity of Colorado School of Medicine, Aurora, Colorado, USA (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of the American College of Surgeons: Wolters Kluwer237:3, s. 515-5241072-75151879-1190

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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Av lärosätet: Umeå universitet

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