WFRF:(Larsen Filip J.)
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- Edman, SebastianGymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik (author)
Need for speed : Human fast-twitch mitochondria favor power over efficiency
- Article/chapterEnglish2024
Publisher, publication year, extent ...
- Elsevier,2024
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-218861
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218861URI
- https://doi.org/10.1016/j.molmet.2023.101854DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-8000URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:154749863URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Objective: Human skeletal muscle consists of a mixture of slow- and fast-twitch fibers with distinct capacities for contraction mechanics, fermentation, and oxidative phosphorylation. While the divergence in mitochondrial volume favoring slow-twitch fibers is well established, data on the fiber type-specific intrinsic mitochondrial function and morphology are highly limited with existing data mainly being generated in animal models. This highlights the need for more human data on the topic.Methods: Here, we utilized THRIFTY, a rapid fiber type identification protocol to detect, sort, and pool fast- and slow-twitch fibers within 6 h of muscle biopsy sampling. Respiration of permeabilized fast- and slow-twitch fiber pools was then analyzed with high-resolution respirometry. Using standardized western blot procedures, muscle fiber pools were subsequently analyzed for control proteins and key proteins related to respiratory capacity.Results: Maximal complex I+II respiration was 25% higher in human slow-twitch fibers compared to fast-twitch fibers. However, per mitochondrial volume, the respiratory rate of mitochondria in fast-twitch fibers was approximately 50% higher for complex I+II, which was primarily mediated through elevated complex II respiration. Furthermore, the abundance of complex II protein and proteins regulating cristae structure were disproportionally elevated in mitochondria of the fast-twitch fibers. The difference in intrinsic respiratory rate was not reflected in fatty acid–or complex I respiration.Conclusion: Mitochondria of human fast-twitch muscle fibers compensate for their lack of volume by substantially elevating intrinsic respiratory rate through increased reliance on complex II.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Idrottsvetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Sport and Fitness Sciences hsv//eng
- Electron transport chain
- Human
- Mitochondria
- Muscle fiber types
- Respiration
- Succinate
- Medicin/Teknik
Added entries (persons, corporate bodies, meetings, titles ...)
- Flockhart, MikaelGymnastik- och idrottshögskolan,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,The Åstrand Laboratory, Department of Physiology, The Swedish School of Sport and Health Sciences, Nutrition and Biomechanics, Stockholm, Sweden,Institutionen för fysiologi, nutrition och biomekanik(Swepub:gih)mikaelf (author)
- Larsen, Filip J,1977-Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik(Swepub:gih)filipl (author)
- Apro, William,1980-Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik(Swepub:gih)williama (author)
- Gymnastik- och idrottshögskolanInstitutionen för fysiologi, nutrition och biomekanik (creator_code:org_t)
Related titles
- In:Molecular Metabolism: Elsevier792212-8778
Internet link
- https://doi.org/10.1016/j.molmet.2023.101854Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1824351/FULLTEXT01.pdffulltext:print
- https://gih.diva-portal.org/smash/get/diva2:1821650/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218861
- https://doi.org/10.1016/j.molmet.2023.101854
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-8000
- http://kipublications.ki.se/Default.aspx?queryparsed=id:154749863
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