Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: results from the european prospective investigation into cancer and nutrition study

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Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer : results from the european prospective investigation into cancer and nutrition study

Pham, Thu Thi (författare): Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Hum-boldt-Universität zu Berlin, Berlin, Germany

Nimptsch, Katharina (författare): Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

Aleksandrova, Krasimira (författare): Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany

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Jenab, Mazda (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, Lyon, France

Fedirko, Veronika (författare): Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States

Wu, Kana (författare): Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States

Eriksen, Anne Kirstine (författare): Danish Cancer Society Research Center, Copenhagen, Denmark

Tjønneland, Anne (författare): Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark

Severi, Gianluca (författare): Université Paris-Saclay, UVSQ, Inserm “Exposome and Heredity” Team, Villejuif, France

Rothwell, Joseph (författare): Université Paris-Saclay, UVSQ, Inserm “Exposome and Heredity” Team, Villejuif, France

Kaaks, Rudolf (författare): Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Katzke, Verena (författare): Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Catalano, Alberto (författare): Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy

Agnoli, Claudia (författare): Epidemiology and Prevention Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Masala, Giovanna (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy

De Magistris, Maria Santucci (författare): Azienda Ospedaliera Universitaria (AOU) Federico II, Naples, Italy

Tumino, Rosario (författare): Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy

Vermeulen, Roel (författare): Institute of Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands

Aizpurua, Amaia (författare): Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain

Trobajo-Sanmartín, Camino (författare): Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarre Institute for Health Research (IdiSNA), Pamplona, Spain

Chirlaque, María-Dolores (författare): Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain

Sánchez, Maria-Jose (författare): Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain

Lu, Sai San Moon (författare): Umeå universitet,Onkologi

Cross, Amanda J. (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Christakoudi, Sofia (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom

Weiderpass, Elisabete (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Pischon, Tobias (författare): Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Hum-boldt-Universität zu Berlin, Berlin, Germany; Biobank Technology Platform, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Core Facility Biobank, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany

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John Wiley & Sons, 2024
2024
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 154:9, s. 1596-1606

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Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine–Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73–1.23; Ptrend =.97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84–1.19; P =.98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet

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Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer : results from the european prospective investigation into cancer and nutrition study

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