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  • Muller, AudreyGlobal Epidemiology, Actelion Pharmaceuticals Ltd, A Janssen Pharmaceutical Company of Johnson & Johnson, Allschwil, Switzerland (author)

Real-world management of patients with pulmonary arterial hypertension : insights from EXPOSURE

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Springer Nature,2024
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-219825
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-219825URI
  • https://doi.org/10.1007/s12325-023-02730-8DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Introduction: Further insights into real-world management and outcomes of patients with pulmonary arterial hypertension (PAH) are needed. This interim analysis of the ongoing, multicentre, prospective EXPOSURE (EUPAS19085) observational study describes characteristics, treatment patterns and outcomes of patients with PAH initiating a new PAH-specific therapy in Europe/Canada.Methods and Results: All analyses were descriptive. In total, 1944 patients with follow-up information were included; the majority were female, with World Health Organization functional class II/III symptoms and with idiopathic PAH or connective tissue disease-associated PAH. Most incident patients (N = 1100; diagnosed for ≤ 6 months) initiated treatment as monotherapy (48%) or double therapy (43%). Of those initiating monotherapy, 38% (199/530) escalated to double therapy (median [Q1, Q3] time to escalation 3.4 [1.9, 6.6] months), and of those initiating double therapy, 17% (78/457) escalated to triple therapy (median [Q1, Q3] time to escalation 7.0 [3.4, 12.7] months) during the observation period (median [Q1, Q3]: 17.0 [7.5, 29.9] months). The majority of the 834 prevalent patients (diagnosed > 6 months) entered the study on initiation of combination therapy and most did not change treatment regimen during the observation period (median [Q1, Q3]: 19.6 [10.2, 32.2] months). One-year survival was 88% for incident patients and 90% for prevalent patients.Conclusions: Results from EXPOSURE suggest a shift towards combination therapy and the alignment of real-world treatment patterns with current guideline recommendations. While survival estimates are encouraging, the extent of monotherapy use at treatment initiation and follow-up highlight an opportunity for further improvements through optimisation of treatment strategies in line with current guidelines.A graphical abstract is also available with this article.Trial Registration Number: EUPAS19085.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Escribano-Subias, PilarPulmonary Hypertension Unit, Cardiology Department, CIBERCV, Hospital 12 de Octubre, Madrid, Spain (author)
  • Fernandes, Catarina C.Global Medical Affairs, Actelion Pharmaceuticals Ltd, A Janssen Pharmaceutical Company of Johnson & Johnson, Allschwil, Switzerland (author)
  • Fontana, MartinaStatistics and Decision Sciences, Janssen-Cilag S.p.A, Cologno Monzese, Italy (author)
  • Lange, Tobias J.Department of Pulmonology, Kreisklinik Bad Reichenhall, Bad Reichenhall, Germany; Faculty of Medicine, Regensburg University, Regensburg, Germany (author)
  • Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001 (author)
  • Gaine, SeanNational Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland (author)
  • Global Epidemiology, Actelion Pharmaceuticals Ltd, A Janssen Pharmaceutical Company of Johnson & Johnson, Allschwil, SwitzerlandPulmonary Hypertension Unit, Cardiology Department, CIBERCV, Hospital 12 de Octubre, Madrid, Spain (creator_code:org_t)

Related titles

  • In:Advances in Therapy: Springer Nature41:3, s. 1103-11190741-238X1865-8652

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