Sökning: WFRF:(Theofilopoulos Argyrios N) >
The lupus-related L...
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
-
- Haraldsson, M Katarina (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Immunologi/immunkemi
-
Louis-Dit-Sully, Christine A (författare)
-
Lawson, Brian R (författare)
-
visa fler...
-
Sternik, Gabriel (författare)
-
Santiago-Raber, Marie-Laure (författare)
-
Gascoigne, Nicholas R J (författare)
-
Theofilopoulos, Argyrios N (författare)
-
Kono, Dwight H (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
-
Ingår i: Immunity. - : Elsevier BV. - 1074-7613 .- 1097-4180. ; 28:1, s. 40-51
- Relaterad länk:
-
http://www.cell.com/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Immunity
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas