SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Zapatero Belinchón Francisco J.)
 

Sökning: WFRF:(Zapatero Belinchón Francisco J.) > Innate immune respo...

  • Passos, VaniaHannover Medical School, Institute of Virology, Hannover, Germany (författare)

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-221106
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221106URI
  • https://doi.org/10.1002/jmv.29455DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Severe acute respiratory coronavirus 2 (SARS-CoV-2) causes neurological disease in the peripheral and central nervous system (PNS and CNS, respectively) of some patients. It is not clear whether SARS-CoV-2 infection or the subsequent immune response are the key factors that cause neurological disease. Here, we addressed this question by infecting human induced pluripotent stem cell-derived CNS and PNS neurons with SARS-CoV-2. SARS-CoV-2 infected a low number of CNS neurons and did not elicit a robust innate immune response. On the contrary, SARS-CoV-2 infected a higher number of PNS neurons. This resulted in expression of interferon (IFN) λ1, several IFN-stimulated genes and proinflammatory cytokines. The PNS neurons also displayed alterations characteristic of neuronal damage, as increased levels of sterile alpha and Toll/interleukin receptor motif-containing protein 1, amyloid precursor protein and α-synuclein, and lower levels of cytoskeletal proteins. Interestingly, blockade of the Janus kinase and signal transducer and activator of transcription pathway by Ruxolitinib did not increase SARS-CoV-2 infection, but reduced neuronal damage, suggesting that an exacerbated neuronal innate immune response contributes to pathogenesis in the PNS. Our results provide a basis to study coronavirus disease 2019 (COVID-19) related neuronal pathology and to test future preventive or therapeutic strategies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Henkel, Lisa M.Department of Neurology, Hannover Medical School, Hannover, Germany (författare)
  • Wang, JiayiHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Zapatero-Belinchón, Francisco J.Umeå universitet,Institutionen för klinisk mikrobiologi,University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany (författare)
  • Möller, RebeccaUniversity of Veterinary Medicine Hannover, Foundation, Hannover, Germany (författare)
  • Sun, GuorongHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Waltl, InkenInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany (författare)
  • Schneider, TaliaHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Wachs, AmelieHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Ritter, BirgitHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Kropp, Kai A.Hannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Zhu, ShuyongHannover Medical School, Institute of Virology, Hannover, Germany (författare)
  • Deleidi, MichelaCenter of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany (författare)
  • Kalinke, UlrichCluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany (författare)
  • Schulz, Thomas F.Hannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany (författare)
  • Höglinger, GünterDepartment of Neurology, Hannover Medical School, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany (författare)
  • Gerold, Gisa,1979-Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany(Swepub:umu)gige0003 (författare)
  • Wegner, FlorianDepartment of Neurology, Hannover Medical School, Hannover, Germany (författare)
  • Viejo-Borbolla, AbelHannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany (författare)
  • Hannover Medical School, Institute of Virology, Hannover, GermanyDepartment of Neurology, Hannover Medical School, Hannover, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Medical Virology: John Wiley & Sons96:20146-66151096-9071

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy