Sökning: WFRF:(Zapatero Belinchón Francisco J.) >
Innate immune respo...
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Passos, VaniaHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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John Wiley & Sons,2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-221106
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221106URI
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https://doi.org/10.1002/jmv.29455DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Severe acute respiratory coronavirus 2 (SARS-CoV-2) causes neurological disease in the peripheral and central nervous system (PNS and CNS, respectively) of some patients. It is not clear whether SARS-CoV-2 infection or the subsequent immune response are the key factors that cause neurological disease. Here, we addressed this question by infecting human induced pluripotent stem cell-derived CNS and PNS neurons with SARS-CoV-2. SARS-CoV-2 infected a low number of CNS neurons and did not elicit a robust innate immune response. On the contrary, SARS-CoV-2 infected a higher number of PNS neurons. This resulted in expression of interferon (IFN) λ1, several IFN-stimulated genes and proinflammatory cytokines. The PNS neurons also displayed alterations characteristic of neuronal damage, as increased levels of sterile alpha and Toll/interleukin receptor motif-containing protein 1, amyloid precursor protein and α-synuclein, and lower levels of cytoskeletal proteins. Interestingly, blockade of the Janus kinase and signal transducer and activator of transcription pathway by Ruxolitinib did not increase SARS-CoV-2 infection, but reduced neuronal damage, suggesting that an exacerbated neuronal innate immune response contributes to pathogenesis in the PNS. Our results provide a basis to study coronavirus disease 2019 (COVID-19) related neuronal pathology and to test future preventive or therapeutic strategies.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Henkel, Lisa M.Department of Neurology, Hannover Medical School, Hannover, Germany
(författare)
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Wang, JiayiHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Zapatero-Belinchón, Francisco J.Umeå universitet,Institutionen för klinisk mikrobiologi,University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
(författare)
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Möller, RebeccaUniversity of Veterinary Medicine Hannover, Foundation, Hannover, Germany
(författare)
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Sun, GuorongHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Waltl, InkenInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany
(författare)
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Schneider, TaliaHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Wachs, AmelieHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Ritter, BirgitHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Kropp, Kai A.Hannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Zhu, ShuyongHannover Medical School, Institute of Virology, Hannover, Germany
(författare)
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Deleidi, MichelaCenter of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
(författare)
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Kalinke, UlrichCluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany
(författare)
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Schulz, Thomas F.Hannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
(författare)
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Höglinger, GünterDepartment of Neurology, Hannover Medical School, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
(författare)
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Gerold, Gisa,1979-Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany(Swepub:umu)gige0003
(författare)
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Wegner, FlorianDepartment of Neurology, Hannover Medical School, Hannover, Germany
(författare)
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Viejo-Borbolla, AbelHannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
(författare)
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Hannover Medical School, Institute of Virology, Hannover, GermanyDepartment of Neurology, Hannover Medical School, Hannover, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Medical Virology: John Wiley & Sons96:20146-66151096-9071
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Till lärosätets databas
- Av författaren/redakt...
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Passos, Vania
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Henkel, Lisa M.
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Wang, Jiayi
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Zapatero-Belinch ...
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Möller, Rebecca
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Sun, Guorong
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visa fler...
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Waltl, Inken
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Schneider, Talia
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Wachs, Amelie
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Ritter, Birgit
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Kropp, Kai A.
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Zhu, Shuyong
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Deleidi, Michela
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Kalinke, Ulrich
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Schulz, Thomas F ...
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Höglinger, Günte ...
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Gerold, Gisa, 19 ...
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Wegner, Florian
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Viejo-Borbolla, ...
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visa färre...
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