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BMI and breast canc...
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Von Holle, AnnBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
(author)
BMI and breast cancer risk around age at menopause
- Article/chapterEnglish2024
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Elsevier,2024
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LIBRIS-ID:oai:DiVA.org:umu-221666
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221666URI
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https://doi.org/10.1016/j.canep.2024.102545DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: A high body mass index (BMI, kg/m2) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.Methods: We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first. Analyses included 609,880 women in 16 prospective studies, including 9956 who developed breast cancer before age 55. We fitted three BMI hazard ratio (HR) models over age-time: constant, linear, or nonlinear (via splines), applying piecewise exponential additive mixed models, with age as the primary time scale. We divided person-time into four strata: premenopause; postmenopause due to natural menopause; postmenopause because of interventional loss of ovarian function (bilateral oophorectomy (BO) or chemotherapy); postmenopause due to hysterectomy without BO. Sensitivity analyses included stratifying by BMI in young adulthood, or excluding women using menopausal hormone therapy.Results: The constant BMI HR model provided the best fit for all four menopausal status groups. Under this model, the estimated association between a five-unit increment in BMI and breast cancer risk was HR=0.87 (95% CI: 0.85, 0.89) before menopause, HR=1.00 (95% CI: 0.96, 1.04) after natural menopause, HR=0.99 (95% CI: 0.93, 1.05) after interventional loss of ovarian function, and HR=0.88 (95% CI: 0.76, 1.02) after hysterectomy without BO.Conclusion: The BMI breast cancer HRs remained less than or near one during the 45–55 year age range indicating that the transition to a positive association between BMI and risk occurs after age 55.
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Adami, Hans-OlovClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinksa Institutet, Stockholm, Sweden
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Baglietto, LauraDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Berrington, AmyDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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Bertrand, Kimberly A.Slone Epidemiology Center, Boston University, MA, Boston, United States
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Blot, WilliamVanderbilt University Medical Center, TN, Nashville, United States
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Chen, YuDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, NY, New York, United States
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DeHart, Jessica ClagueSchool of Community and Global Health, Claremont Graduate University, CA, Claremont, United States
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Dossus, LaureNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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Eliassen, A. HeatherDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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Fournier, AgnesCentre for Research in Epidemiology and Statistics, Paris, France
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Garcia-Closas, MontseDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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Giles, GrahamCancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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Guevara, MarcelaInstituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
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Hankinson, Susan E.Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States
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Heath, AliciaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Jones, Michael E.Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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Joshu, Corinne E.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
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Kirsh, Victoria A.Ontario Institute for Cancer Research, ON, Toronto, Canada
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Kitahara, Cari M.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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Koh, Woon-PuayHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore
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Linet, Martha S.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
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Park, Hannah LuiDepartment of Pathology and Laboratory Medicine, Department of Epidemiology, UC Irvine School of Medicine, CA, Irvine, United States
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Masala, GiovannaInstitute for the Study and Prevention of Cancer, Florence, Italy
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Mellemkjaer, LeneDiet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark
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Milne, Roger L.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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O'Brien, Katie M.Epidemiology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
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Palmer, Julie R.Slone Epidemiology Center, Boston University, MA, Boston, United States
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Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Rohan, Thomas E.Albert Einstein College of Medicine, NY, Bronx, United States
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Shrubsole, Martha J.Vanderbilt University Medical Center, TN, Nashville, United States
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Sund, MalinUmeå universitet,Kirurgi(Swepub:umu)masu0021
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Tamimi, RullaDepartment of Population Health Sciences, Weill Cornell Medical College, NY, United States
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Tin Tin, SandarCancer Epidemiology Unit, Oxford Population Health, University of Oxford, United Kingdom
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Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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Vermeulen, Roel CHInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France
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Willett, Walter C.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
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Yuan, Jian-MinDivision of Cancer Control and Population Science, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States; Department of Epidemiology, University of Pittsburgh, PA, Pittsburgh, United States
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Zeleniuch-Jacquotte, AnneDepartment of Population Health, NYU Grossman School of Medicine, NY, United States
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Nichols, Hazel B.Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, NC, Chapel Hill, United States
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Sandler, Dale P.Epidemiology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
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Swerdlow, Anthony J.Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom
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Schoemaker, Minouk J.Real World Solutions, IQVIA, Netherlands
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Weinberg, Clarice R.Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
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Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United StatesClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinksa Institutet, Stockholm, Sweden
(creator_code:org_t)
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In:Cancer Epidemiology: Elsevier891877-78211877-783X
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Von Holle, Ann
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Adami, Hans-Olov
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Baglietto, Laura
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Berrington, Amy
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Bertrand, Kimber ...
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Blot, William
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show more...
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Chen, Yu
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DeHart, Jessica ...
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Dossus, Laure
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Eliassen, A. Hea ...
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Fournier, Agnes
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Garcia-Closas, M ...
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Giles, Graham
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Guevara, Marcela
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Hankinson, Susan ...
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Heath, Alicia
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Jones, Michael E ...
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Joshu, Corinne E ...
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Kaaks, Rudolf
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Kirsh, Victoria ...
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Kitahara, Cari M ...
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Koh, Woon-Puay
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Linet, Martha S.
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Park, Hannah Lui
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Masala, Giovanna
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Mellemkjaer, Len ...
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Milne, Roger L.
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O'Brien, Katie M ...
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Palmer, Julie R.
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Riboli, Elio
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Rohan, Thomas E.
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Shrubsole, Marth ...
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Sund, Malin
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Tamimi, Rulla
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Tin Tin, Sandar
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Visvanathan, Kal ...
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Vermeulen, Roel ...
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Weiderpass, Elis ...
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Willett, Walter ...
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Yuan, Jian-Min
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Zeleniuch-Jacquo ...
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Nichols, Hazel B ...
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Sandler, Dale P.
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Swerdlow, Anthon ...
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Schoemaker, Mino ...
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Weinberg, Claric ...
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