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  • Rask, GunillaUmeå universitet,Patologi,Kirurgi (författare)

Immune cell infiltrate in ductal carcinoma in situ and the risk of dying from breast cancer : case-control study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-221843
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221843URI
  • https://doi.org/10.1093/bjs/znae037DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238395442URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Studies identifying risk factors for death from breast cancer after ductal carcinoma in situ (DCIS) are rare. In this retrospective nested case-control study, clinicopathological factors in women treated for DCIS and who died from breast cancer were compared with those of patients with DCIS who were free from metastatic disease.Methods: The study included patients registered with DCIS without invasive carcinoma in Sweden between 1992 and 2012. This cohort was linked to the National Cause of Death Registry. Of 6964 women with DCIS, 96 were registered with breast cancer as cause of death (cases). For each case, up to four controls (318; women with DCIS, alive and without metastatic breast cancer at the time of death of the corresponding case) were selected randomly by incidence density sampling. Whole slides of tumour tissue were evaluated for DCIS grade, comedo necrosis, and intensity of periductal lymphocytic infiltrate. Composition of the immune cell infiltrate, expression of oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and proliferation marker Ki-67 were scored on tissue microarrays. Clinical information was obtained from medical records. Information on date, site, and histological characteristics of local and distant recurrences was obtained from medical records for both cases and controls.Results: Tumour tissue was analysed from 65 cases and 195 controls. Intense periductal lymphocytic infiltrate around DCIS was associated with an increased risk of later dying from breast cancer (OR 2.21. 95% c.i. 1.01 to 4.84). Tumours with more intense lymphocytic infiltrate had a lower T cell/B cell ratio. None of the other biomarkers correlated with increased risk of breast cancer death.Conclusion: The immune response to DCIS may influence the risk of dying from breast cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wadsten, CharlottaUmeå universitet,Kirurgi,Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden(Swepub:umu)chwa0052 (författare)
  • Acs, BalazsDepartment of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Hartman, JohanKarolinska Institutet (författare)
  • Fredriksson, IrmaDepartment of Breast Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (författare)
  • Garmo, HansDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology and Urology Research, King's College London, London, United Kingdom (författare)
  • Wärnberg, FredrikDepartment of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021 (författare)
  • Umeå universitetPatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Surgery: Oxford University Press111:20007-13231365-2168

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