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Lung cancer in ever...
Lung cancer in ever- and never-smokers : findings from multi-population GWAS studies
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- Li, Yafang (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Xiao, Xiangjun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Li, Jianrong (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Han, Younghun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Cheng, Chao (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Fernandes, Gail F. (författare)
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Slewitzke, Shannon E. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Rosenberg, Susan M. (författare)
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Zhu, Meng (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Byun, Jinyoung (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Bossé, Yohan (författare)
- Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Canada
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- McKay, James D. (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Albanes, Demetrios (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- Lam, Stephen (författare)
- Department of Integrative Oncology, University of British Columbia, BC, Vancouver, Canada
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- Tardon, Adonina (författare)
- Public Health Department, University of Oviedo, Asturias, Spain
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- Chen, Chu (författare)
- Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Bojesen, Stig E. (författare)
- Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Landi, Maria T. (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- Johansson, Mattias (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Risch, Angela (författare)
- Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria
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- Bickeböller, Heike (författare)
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
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- Wichmann, H-Erich (författare)
- Helmholtz-Munich Institute of Epidemiology, Neuherberg, Germany
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- Christiani, David C. (författare)
- Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, MA, Boston, United States
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- Rennert, Gad (författare)
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
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- Arnold, Susanne M. (författare)
- University of Kentucky, Markey Cancer Center, KY, Lexington, United States
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- Goodman, Gary E. (författare)
- Swedish Cancer Institute, WA, Seattle, United States
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- Field, John K. (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
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- Davies, Michael P A (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
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- Shete, Sanjay (författare)
- Department of Biostatistics, University of Texas, MD Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, University of Texas MD Anderson Cancer Center, TX, Houston, United States
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- Marchand, Loïc Le (författare)
- Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States
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- Liu, Geoffrey (författare)
- University Health Network- The Princess Margaret Cancer Centre, CA, Toronto, United States
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- Hung, Rayjean J. (författare)
- Luenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Canada
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- Andrew, Angeline S. (författare)
- Departments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, New Hampshire
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center, Nijmegen, Netherlands
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- Sun, Ryan (författare)
- Department of Biostatistics, University of Texas, MD Anderson Cancer Center, TX, Houston, United States
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- Zienolddiny, Shanbeh (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Grankvist, Kjell (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Johansson, Mikael (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Caporaso, Neil E. (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- Cox, Angela (författare)
- Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
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- Hong, Yun-Chul (författare)
- Department of Preventive Medicine, Seoul National University College of Medicine, Republic of South Korea, Seoul, South Korea
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- Lazarus, Philip (författare)
- Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States
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- Schabath, Matthew B. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, Puerto Rico
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- Aldrich, Melinda C. (författare)
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States
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- Schwartz, Ann G. (författare)
- Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
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- Gorlov, Ivan (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Purrington, Kristen S. (författare)
- Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
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- Yang, Ping (författare)
- Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, MN, Rochester, United States
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- Liu, Yanhong (författare)
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Bailey-Wilson, Joan E. (författare)
- National Human Genome Research Institute, NIH, MD, Baltimore, Liberia
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- Pinney, Susan M. (författare)
- University of Cincinnati College of Medicine, OH, Cincinnati, United States
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- Mandal, Diptasri (författare)
- Louisiana State University Health Sciences Center, LA, New Orleans, United States
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- Willey, James C. (författare)
- College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio
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- Gaba, Colette (författare)
- The University of Toledo College of Medicine, Toledo, Ohio
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- Brennan, Paul (författare)
- Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Canada
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- Xia, Jun (författare)
- Creighton University School of Medicine, NE, Omaha, United States
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- Shen, Hongbing (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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(creator_code:org_t)
- American Association For Cancer Research (AACR), 2024
- 2024
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 33:3, s. 389-399
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer.METHODS: We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis including expression quantitative trait loci (eQTL) colocalization and DNA damage assays, and annotation studies were conducted to evaluate the functional roles of the variants. We further evaluated the impact of smoking quantity on lung cancer risk for the variants associated with ever-smoking lung cancer.RESULTS: Five novel independent loci, GABRA4, intergenic region 12q24.33, LRRC4C, LINC01088, and LCNL1 were identified with the association at two or three populations (P < 5 × 10-8). Further functional analysis provided multiple lines of evidence suggesting the variants affect lung cancer risk through excessive DNA damage (GABRA4) or cis-regulation of gene expression (LCNL1). The risk of variants from 12 independent regions, including the well-known CHRNA5, associated with ever-smoking lung cancer was evaluated for never-smokers, light-smokers (packyear ≤ 20), and moderate-to-heavy-smokers (packyear > 20). Different risk patterns were observed for the variants among the different groups by smoking behavior.CONCLUSIONS: We identified novel variants associated with lung cancer in only ever- or never-smoking groups that were missed by prior main-effect association studies. IMPACT: Our study highlights the genetic heterogeneity between ever- and never-smoking lung cancer and provides etiologic insights into the complicated genetic architecture of this deadly cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Li, Yafang
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Xiao, Xiangjun
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Li, Jianrong
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Han, Younghun
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Cheng, Chao
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Fernandes, Gail ...
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visa fler...
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Slewitzke, Shann ...
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Rosenberg, Susan ...
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Zhu, Meng
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Byun, Jinyoung
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Bossé, Yohan
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McKay, James D.
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Albanes, Demetri ...
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Lam, Stephen
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Tardon, Adonina
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Chen, Chu
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Bojesen, Stig E.
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Landi, Maria T.
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Johansson, Matti ...
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Risch, Angela
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Bickeböller, Hei ...
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Wichmann, H-Eric ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne ...
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Goodman, Gary E.
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Field, John K.
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Davies, Michael ...
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Shete, Sanjay
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Marchand, Loïc L ...
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Liu, Geoffrey
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Hung, Rayjean J.
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Sun, Ryan
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Caporaso, Neil E ...
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Cox, Angela
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Hong, Yun-Chul
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Schwartz, Ann G.
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Gorlov, Ivan
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Purrington, Kris ...
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Yang, Ping
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Liu, Yanhong
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Bailey-Wilson, J ...
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Pinney, Susan M.
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Mandal, Diptasri
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Willey, James C.
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Gaba, Colette
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Brennan, Paul
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Xia, Jun
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Shen, Hongbing
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Amos, Christophe ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Cancer Epidemiol ...
- Av lärosätet
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Umeå universitet