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Cohort profile: SUP...
Cohort profile: SUPER-Finland - the Finnish study for hereditary mechanisms of psychotic disorders
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- Lähteenvuo, Markku (author)
- Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Ahola-Olli, Ari (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
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- Suokas, Kimmo (author)
- Faculty of Social Sciences, Tampere University, Tampere, Finland
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- Holm, Minna (author)
- Finnish Institute for Health and Welfare, Helsinki, Finland
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- Misiewicz, Zuzanna (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Jukuri, Tuomas (author)
- Department of Psychiatry, Oulu University Hospital, Oulu, Finland
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- Männynsalo, Teemu (author)
- Psychiatric and Substance Abuse Services, City of Helsinki, Helsinki, Finland
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- Wegelius, Asko (author)
- Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Haaki, Willehard (author)
- Department of Psychiatry, University of Turku, Turku, Finland; Department of Psychiatry, TYKS Turku University Hospital, Turku, Finland
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- Kajanne, Risto (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Kyttälä, Aija (author)
- Finnish Institute for Health and Welfare, Helsinki, Finland
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- Tuulio-Henriksson, Annamari (author)
- Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
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- Lahdensuo, Kaisla (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Häkkinen, Katja (author)
- Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland
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- Hietala, Jarmo (author)
- Department of Psychiatry, University of Turku, Turku, Finland; Department of Psychiatry, TYKS Turku University Hospital, Turku, Finland
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- Paunio, Tiina (author)
- Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Niemi-Pynttäri, Jussi (author)
- Psychiatric and Substance Abuse Services, City of Helsinki, Helsinki, Finland
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- Kieseppä, Tuula (author)
- Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
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- Veijola, Juha (author)
- Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland; Medical Research Centre Oulu, University Hospital of Oulu and University of Oulu, Oulu, Finland
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- Lönnqvist, Jouko (author)
- Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
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- Isometsä, Erkki (author)
- Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
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- Kampman, Olli (author)
- Umeå universitet,Psykiatri,Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, Pirkanmaa Wellbeing Services County, Tampere, Finland; Department of Clinical Medicine (Psychiatry), Faculty of Medicine, University of Turku, Turku, Finland; Department of Psychiatry, Wellbeing Services County of Ostrobothnia, Vaasa, Finland
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- Tiihonen, Jari (author)
- Karolinska Institutet
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- Hyman, Steven (author)
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Stem Cell and Regenerative Biology, Harvard University, MA, Cambridge, United States
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- Neale, Benjamin (author)
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
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- Daly, Mark (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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- Suvisaari, Jaana (author)
- Finnish Institute for Health and Welfare, Helsinki, Finland
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- Palotie, Aarno (author)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, MA, Cambridge, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, MA, Boston, United States
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(creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- English.
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In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 13:4
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- PURPOSE: SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to include Asian, Latin American and African populations in addition to known population isolates, such as Finland.PARTICIPANTS: 10 474 individuals aged 18 years or older were recruited throughout the country. The subjects have been genotyped with a genome-wide genotyping chip and exome sequenced. A subset of 897 individuals selected from known population sub-isolates were selected for whole-genome sequencing. Recruitment was done between November 2015 and December 2018.FINDINGS TO DATE: 5757 (55.2%) had a diagnosis of schizophrenia, 944 (9.1%) schizoaffective disorder, 1612 (15.5%) type I or type II bipolar disorder, 532 (5.1 %) psychotic depression, 1047 (10.0%) other psychosis and for 530 (5.1%) self-reported psychosis at recruitment could not be confirmed from register data. Mean duration of schizophrenia was 22.0 years at the time of the recruitment. By the end of the year 2018, 204 of the recruited individuals had died. The most common cause of death was cardiovascular disease (n=61) followed by neoplasms (n=40). Ten subjects had psychiatric morbidity as the primary cause of death.FUTURE PLANS: Compare the effects of common variants, rare variants and copy number variations (CNVs) on severity of psychotic illness. In addition, we aim to track longitudinal course of illness based on nation-wide register data to estimate how phenotypic and genetic differences alter it.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Depression & mood disorders
- PSYCHIATRY
- Schizophrenia & psychotic disorders
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMJ Open
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To the university's database
- By the author/editor
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Lähteenvuo, Mark ...
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Ahola-Olli, Ari
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Suokas, Kimmo
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Holm, Minna
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Misiewicz, Zuzan ...
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Jukuri, Tuomas
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show more...
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Männynsalo, Teem ...
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Wegelius, Asko
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Haaki, Willehard
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Kajanne, Risto
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Kyttälä, Aija
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Tuulio-Henriksso ...
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Lahdensuo, Kaisl ...
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Häkkinen, Katja
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Hietala, Jarmo
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Paunio, Tiina
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Niemi-Pynttäri, ...
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Kieseppä, Tuula
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Veijola, Juha
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Lönnqvist, Jouko
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Isometsä, Erkki
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Kampman, Olli
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Tiihonen, Jari
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Hyman, Steven
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Neale, Benjamin
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Daly, Mark
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Suvisaari, Jaana
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Palotie, Aarno
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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BMJ Open
- By the university
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Umeå University
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Karolinska Institutet