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Sökning: id:"swepub:oai:DiVA.org:umu-222869" > Combined amniotic m...

  • Wang, YupeiGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)

Combined amniotic membrane and self-powered electrical stimulator bioelectronic dress promotes wound healing

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • American Chemical Society (ACS),2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-222869
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222869URI
  • https://doi.org/10.1021/acsami.3c18547DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells. Live/dead staining, CCK-8, and scratch-wound-closure assays were performed in vitro. Compared with amniotic membrane treatment alone, the E-dress promoted cell proliferation and migration of mouse fibroblast cells and lower cytotoxicity. In a mouse full-skin defect model, the E-dress achieved significantly accelerated wound closure. Histological analysis revealed that E-dress treatment promoted epithelialization and neovascularization in mouse skin. The E-dress exhibited a desirable flexibility that aligned with tissue organization and displayed maximum bioactivity within a short period to overcome rapid degradation, implying great potential for clinical applications.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wu, HanBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China (författare)
  • Xiao, AoBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China (författare)
  • Zhu, JingCollege of Life Science, Northwest Normal University, Lanzhou, China (författare)
  • Qiu, JieGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Yang, KuanBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China (författare)
  • Liu, QingGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Hao, ShengjuGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Hui, LingGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Zhou, XinUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)xizh0019 (författare)
  • Hou, QinzhengCollege of Life Science, Northwest Normal University, Lanzhou, China (författare)
  • Su, HaixiangGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Meng, ZhaoyanGansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China (författare)
  • Chang, LingqianBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China (författare)
  • Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, ChinaBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:ACS Applied Materials and Interfaces: American Chemical Society (ACS)16:13, s. 15809-158181944-82441944-8252

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