SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Davies Eleanor)
 

Search: WFRF:(Davies Eleanor) > Research protocol f...

  • Rajwa, PawelDepartment of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria (author)

Research protocol for an observational health data analysis on the adverse events of systemic treatment in patients with metastatic hormone-sensitive prostate cancer : big data analytics using the PIONEER platform

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Elsevier,2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-222894
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222894URI
  • https://doi.org/10.1016/j.euros.2024.02.019DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Combination therapies in metastatic hormone-sensitive prostate cancer (mHSPC), which include the addition of an androgen receptor signaling inhibitor and/or docetaxel to androgen deprivation therapy, have been a game changer in the management of this disease stage. However, these therapies come with their fair share of toxicities and side effects. The goal of this observational study is to report drug-related adverse events (AEs), which are correlated with systemic combination therapies for mHSPC. Determining the optimal treatment option requires large cohorts to estimate the tolerability and AEs of these combination therapies in “real-life” patients with mHSPC, as provided in this study. We use a network of databases that includes population-based registries, electronic health records, and insurance claims, containing the overall target population and subgroups of patients defined by unique certain characteristics, demographics, and comorbidities, to compute the incidence of common AEs associated with systemic therapies in the setting of mHSPC. These data sources are standardised using the Observational Medical Outcomes Partnership Common Data Model. We perform the descriptive statistics as well as calculate the AE incidence rate separately for each treatment group, stratified by age groups and index year. The time until the first event is estimated using the Kaplan-Meier method within each age group. In the case of episodic events, the anticipated mean cumulative counts of events are calculated. Our study will allow clinicians to tailor optimal therapies for mHSPC patients, and they will serve as a basis for comparative method studies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Borkowetz, AngelikaDepartment of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany (author)
  • Abbott, ThomasEuropean Association of Urology, Nijmegen, Netherlands (author)
  • Alberti, AndreaUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy (author)
  • Bjartell, AndersDepartment of Translational Medicine, Lund University, Lund, Sweden (author)
  • Brash, James T.IQVIA, Real World Solutions, Brighton, United Kingdom (author)
  • Campi, RiccardoUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy (author)
  • Chilelli, AndrewAstellas Pharma Europe Ltd, Surrey, United Kingdom (author)
  • Conover, MitchellJanssen Research & Development, NJ, Titusville, United States (author)
  • Constantinovici, NiculaeBayer AG, Berlin, Germany (author)
  • Davies, EleanorIQVIA, Real World Solutions, Brighton, United Kingdom (author)
  • De Meulder, BertrandAssociation EISBM, Vourles, France (author)
  • Eid, SherrineSAS Institute, NC, Cary, United States (author)
  • Gacci, MauroUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy (author)
  • Golozar, AsiehOdysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States (author)
  • Hafeez, HaroonShaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar, Pakistan (author)
  • Haque, SamiulSAS Institute, NC, Cary, United States (author)
  • Hijazy, AymanAssociation EISBM, Vourles, France (author)
  • Hulsen, TimDepartment of Hospital Services & Informatics, Philips Research, Eindhoven, Netherlands (author)
  • Josefsson, Andreas,1979-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för diagnostik och intervention,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:umu)aasjon01 (author)
  • Khalid, SaraUniversity of Oxford, Oxford, United Kingdom (author)
  • Kolde, RaivoInstitute of Computer Science, University of Tartu, Estonia, Tartu, Estonia (author)
  • Kotik, DanielCenter for Advanced Systems Understanding, Görlitz, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (author)
  • Kurki, SamuBayer OY, Turku, Finland (author)
  • Lambrecht, MarkSAS Institute, NC, Cary, United States (author)
  • Leung, Chi-HoS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong (author)
  • Moreno, JuliaSAS Institute, NC, Cary, United States (author)
  • Nicoletti, RossellaUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy (author)
  • Nieboer, DaanErasmus MC University Medical Center, Rotterdam, Netherlands (author)
  • Oja, MarekInstitute of Computer Science, University of Tartu, Estonia, Tartu, Estonia (author)
  • Palanisamy, SoundaryaSAS Institute, NC, Cary, United States (author)
  • Prinsen, PeterNetherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands (author)
  • Reich, ChristianOdysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States (author)
  • Raffaele Resta, GiulioUnit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy (author)
  • Ribal, Maria J.Uro-Oncology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain (author)
  • Gómez Rivas, JuanDepartment of Urology, Hospital Clinico San Carlos, Madrid, Spain (author)
  • Smith, EmmaGuidelines Office, European Association of Urology, Arnhem, Netherlands (author)
  • Snijder, RobertJanssen Research & Development, NJ, Titusville, United States (author)
  • Steinbeisser, CarlCollaborate Project Management, Munich, Germany (author)
  • Vandenberghe, FrederikSAS Institute, NC, Cary, United States (author)
  • Cornford, PhilipLiverpool University Hospitals NHS Trust, Liverpool, United Kingdom (author)
  • Evans-Axelsson, SusanBayer AG, Berlin, Germany (author)
  • N'Dow, JamesAcademic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom (author)
  • Willemse, Peter-Paul M.Department of Urology, Cancer Center, University Medical Center Utrecht, Utrecht, Netherlands (author)
  • Department of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, AustriaDepartment of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany (creator_code:org_t)

Related titles

  • In:European Urology Open Science: Elsevier63, s. 81-882666-16912666-1683

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view