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Genetic risk impact...
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
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- Tian, Yu (författare)
- School of Public Health, Capital Medical University, Beijing, China; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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visa fler...
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Baurley, James W. (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Bien, Stephanie A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Bishop, D. Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, VIC, Parkville, Australia
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- Budiarto, Arif (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Campbell, Peter T. (författare)
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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- Carreras-Torres, Robert (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute Dr Josep Trueta (IDIBGI), Girona, Salt, Spain
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- Casey, Graham (författare)
- Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
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- Chan, Andrew T. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Chen, Rui (författare)
- School of Public Health, Capital Medical University, Beijing, China
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- Chen, Xuechen (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Conti, David V. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Díez-Obrero, Virginia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Dimou, Niki (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Drew, David A. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Gallinger, Steven (författare)
- Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
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- Giles, Graham G. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Gruber, Stephen B. (författare)
- Department of Medical Oncology & amp; Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hidaka, Akihisa (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Huyghe, Jeroen R. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
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- Jordahl, Kristina M. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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- Joshi, Amit D. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
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- Kawaguchi, Eric (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Kim, Andre E. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Kundaje, Anshul (författare)
- Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Larsson, Susanna C. (författare)
- Karolinska Institutet
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- Marchand, Loic Le (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Lewinger, Juan Pablo (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Moreno, Victor (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L’Hospitalet de Llobregat, Barcelona, Spain
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- Morrison, John (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Nan, Hongmei (författare)
- Department of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indianapolis, IN, Indianapolis, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura’a University, Mecca, Saudi Arabia
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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- Obón-Santacana, Mireia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Ogino, Shuji (författare)
- Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Tokyo Medical and Dental University (Institute of Science Tokyo), Tokyo, Japan
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- Ose, Jennifer (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States; Hochschule Hannover, University of Applied Sciences and Arts, Department III: Media, Information and Design, Hannover, Germany
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- Pardamean, Bens (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Pellatt, Andrew J. (författare)
- Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, TX, Houston, United States
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- Peoples, Anita R. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Potter, John D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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- Prentice, Ross L. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Rennert, Gad (författare)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Ruiz-Narvaez, Edward A. (författare)
- Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Schoen, Robert E. (författare)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Shcherbina, Anna (författare)
- Biomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States
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- Stern, Mariana C. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Su, Yu-Ru (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
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- Thibodeau, Stephen N. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Thomas, Duncan C. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Tsilidis, Konstantinos K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- van Duijnhoven, Franzel J. B. (författare)
- Division of Human Nutrition and Health, Wageningen University & amp; Research, Wageningen, Netherlands
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Woods, Michael O. (författare)
- Memorial University of Newfoundland, Discipline of Genetics, NL, St. John’s, Canada
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- Wu, Anna H. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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- Gauderman, W. James (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 130:10, s. 1687-1696
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk.Methods: We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated.Results: The reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (p-value = 2.7 × 10−8). At the highest quartile of PRS, the 30-year CRC risk was statistically significantly lower for women taking any MHT than for women not taking any MHT, 3.7% (3.3%–4.0%) vs 6.1% (5.7%–6.5%) (difference 2.4%, P-value = 1.83 × 10−14); these differences were also statistically significant but smaller in magnitude in the lowest PRS quartile, 1.6% (1.4%–1.8%) vs 2.2% (1.9%–2.4%) (difference 0.6%, P-value = 1.01 × 10−3), indicating 4 times greater reduction in absolute risk associated with any MHT use in the highest compared to the lowest quartile of genetic CRC risk.Conclusions: MHT use has a greater impact on the reduction of CRC risk for women at higher genetic risk. These findings have implications for the development of risk prediction models for CRC and potentially for the consideration of genetic information in the risk-benefit assessment of MHT use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Tian, Yu
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Lin, Yi
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Qu, Conghui
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Arndt, Volker
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Baurley, James W ...
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Berndt, Sonja I.
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Bien, Stephanie ...
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Bishop, D. Timot ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Budiarto, Arif
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Campbell, Peter ...
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Carreras-Torres, ...
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Casey, Graham
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Chan, Andrew T.
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Chen, Rui
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Chen, Xuechen
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Conti, David V.
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Díez-Obrero, Vir ...
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Dimou, Niki
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Drew, David A.
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gruber, Stephen ...
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Gunter, Marc J.
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Harlid, Sophia, ...
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Harrison, Tabith ...
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Hidaka, Akihisa
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Hoffmeister, Mic ...
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Huyghe, Jeroen R ...
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Jenkins, Mark A.
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Jordahl, Kristin ...
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Joshi, Amit D.
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Keku, Temitope O ...
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Kawaguchi, Eric
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Kim, Andre E.
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Kundaje, Anshul
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Larsson, Susanna ...
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Marchand, Loic L ...
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Lewinger, Juan P ...
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Li, Li
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Moreno, Victor
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Morrison, John
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Murphy, Neil
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Nan, Hongmei
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Nassir, Rami
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Newcomb, Polly A ...
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Obón-Santacana, ...
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Ogino, Shuji
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Ose, Jennifer
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Pardamean, Bens
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Pellatt, Andrew ...
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Peoples, Anita R ...
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Platz, Elizabeth ...
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Potter, John D.
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Prentice, Ross L ...
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Rennert, Gad
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Ruiz-Narvaez, Ed ...
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Sakoda, Lori C.
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Schoen, Robert E ...
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Shcherbina, Anna
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Stern, Mariana C ...
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Su, Yu-Ru
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Thibodeau, Steph ...
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Thomas, Duncan C ...
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Tsilidis, Konsta ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Visvanathan, Kal ...
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Peters, Ulrike
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Gauderman, W. Ja ...
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Hsu, Li
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Chang-Claude, Je ...
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