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Stromal type I coll...
Stromal type I collagen in breast cancer : correlation to prognostic biomarkers and prediction of chemotherapy response
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- Jansson, Malin, 1978- (författare)
- Umeå universitet,Kirurgi
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- Lindberg, Jessica (författare)
- Umeå universitet,Kirurgi
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- Rask, Gunilla (författare)
- Umeå universitet,Patologi
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- Svensson, Johan, 1978- (författare)
- Umeå universitet,Statistik,Kirurgi
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- Billing, Ola, 1981- (författare)
- Umeå universitet,Kirurgi
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- Nazemroaya, Anoosheh (författare)
- Umeå universitet,Patologi
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- Berglund, Anette, 1960- (författare)
- Umeå universitet,Kirurgi
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- Wärnberg, Fredrik (författare)
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Clinical Breast Cancer. - : Elsevier. - 1526-8209 .- 1938-0666.
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Fibrillar collagens accumulate in the breast cancer stroma and appear as poorly defined spiculated masses in mammography imaging. The prognostic value of tissue type I collagen remains elusive in treatment-naïve and chemotherapy-treated breast cancer patients. Here, type I collagen mRNA and protein expression were analysed in 2 large independent breast cancer cohorts. Levels were related to clinicopathological parameters, prognostic biomarkers, and outcome.Method: COL1A1 mRNA expression was analysed in 2509 patients with breast cancer obtained from the cBioPortal database. Type I collagen protein expression was studied by immunohistochemistry in 1395 women diagnosed with early invasive breast cancer.Results: Low COL1A1 mRNA and protein levels correlated with poor prognosis features, such as hormone receptor negativity, high histological grade, triple-negative subtype, node positivity, and tumour size. In unadjusted analysis, high stromal type I collagen protein expression was associated with improved overall survival (OS) (HR = 0.78, 95% CI = 0.61-0.99, p = .043) and trended towards improved breast cancer–specific survival (BCSS) (HR = 0.65, 95% CI = 0.42-1.01, P = 0.053), although these findings were lost after adjustment for other clinical variables. In unadjusted analysis, high expression of type I collagen was associated with better OS (HR = 0.70, 95% CI = 0.55-0.90, P = .006) and BCSS (HR = 0.55, 95% CI = 0.34-0.88, P = .014) among patients not receiving chemotherapy. Strikingly, the opposite was observed among patients receiving chemotherapy. There, high expression of type I collagen was instead associated with worse OS (HR = 1.83, 95% CI = 0.65-5.14, P = .25) and BCSS (HR = 1.72, 95% CI = 0.54-5.50, P = .357).Conclusion: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Chemotherapy response
- Extracellular matrix
- Tumour microenvironment
- Type I collagen
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Jansson, Malin, ...
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Lindberg, Jessic ...
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Rask, Gunilla
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Svensson, Johan, ...
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Billing, Ola, 19 ...
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Nazemroaya, Anoo ...
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Berglund, Anette ...
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Wärnberg, Fredri ...
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Sund, Malin
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