id:"swepub:oai:DiVA.org:umu-223435"
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- Svensson, Michael B.,Med Dr, docentUmeå universitet,Avdelningen för idrottsmedicin,Umeå Univ, Dept Community Med & Rehabil, Sect Sports Med, Umeå, Sweden. (författare)
Discordant gene expression in subcutaneous adipose and skeletal muscle tissues in response to exercise training
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
- John Wiley & Sons,2024
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-223435
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223435URI
- https://doi.org/10.14814/phy2.15995DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:238561245URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-526573URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Exercise has different effects on different tissues in the body, the sum of which may determine the response to exercise and the health benefits. In the present study, we aimed to investigate whether physical training regulates transcriptional network communites common to both skeletal muscle (SM) and subcutaneous adipose tissue (SAT). Eight such shared transcriptional communities were found in both tissues. Eighteen young overweight adults voluntarily participated in 7 weeks of combined strength and endurance training (five training sessions per week). Biopsies were taken from SM and SAT before and after training. Five of the network communities were regulated by training in SM but showed no change in SAT. One community involved in insulin- AMPK signaling and glucose utilization was upregulated in SM but downregulated in SAT. This diverging exercise regulation was confirmed in two independent studies and was also associated with BMI and diabetes in an independent cohort. Thus, the current finding is consistent with the differential responses of different tissues and suggests that body composition may influence the observed individual whole-body metabolic response to exercise training and help explain the observed attenuated whole-body insulin sensitivity after exercise training, even if it has significant effects on the exercising muscle.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Idrottsvetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Sport and Fitness Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- adipose tissue
- GTEx
- mRNA-sequencing
- obesity
- skeletal muscle
- molekylär cellbiologi
- molecular cell biology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Lovric, AlenDepartment of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Dept Lab Med, Div Clin Physiol, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Clin Physiol, Stockholm, Sweden. (författare)
- Åkerfeldt, TorbjörnUppsala universitet,Klinisk kemi,Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden(Swepub:uu)tak20812 (författare)
- Hellsten, DavidUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.(Swepub:umu)dadhen01 (författare)
- Haas, TaraFaculty of Health, School of Kinesiology and Health Science, York University, Toronto, Canada,York Univ, Fac Hlth, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada. (författare)
- Gustafsson, ThomasKarolinska Institutet,Karolinska Inst, Dept Lab Med, Div Clin Physiol, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Clin Physiol, Stockholm, Sweden.,Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden (författare)
- Rullman, EricDepartment of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Dept Lab Med, Div Clin Physiol, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Clin Physiol, Stockholm, Sweden. (författare)
- Umeå universitetAvdelningen för idrottsmedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Physiological Reports: John Wiley & Sons12:72051-817X
Internetlänk
- https://doi.org/10.14814/phy2.15995Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1851827/FULLTEXT01.pdffulltext:print
- https://uu.diva-portal.org/smash/get/diva2:1851609/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223435
- https://doi.org/10.14814/phy2.15995
- http://kipublications.ki.se/Default.aspx?queryparsed=id:238561245
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-526573
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