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Epidemiologic facto...
Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature
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- Thomas, Claire E. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Georgeson, Peter (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, University of Melbourne, Parkville, Australia
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Steinfelder, Robert S. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, University of Melbourne, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
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- Song, Mingyang (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Um, Caroline Y. (författare)
- Department of Population Science, American Cancer Society, Atlanta, Georgia
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- Hullar, Meredith A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Lynch, Brigid M. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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- Melaku, Yohannes Adama (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; College of Medicine and Public Health, Flinders University, SA, Adelaide, Australia
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- Huyghe, Jeroen R. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Aglago, Elom K. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
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- Boardman, Lisa A. (författare)
- Gastroenterology and Hepatology, Mayo Clinic, MN, Rochester, United States
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- Campbell, Peter T. (författare)
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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- Cao, Yin (författare)
- Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, MO, St Louis, United States; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, MO, St. Louis, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
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- Chan, Andrew T. (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Drew, David A. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- French, Amy J. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Giannakis, Marios (författare)
- Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
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- Goode, Ellen L. (författare)
- Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, MN, Rochester, United States
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- Gruber, Stephen B. (författare)
- Department of Medical Oncology and Therapeutics Research and Center for Precision Medicine, City of Hope National Medical Center, Duarte, California
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- Gsur, Andrea (författare)
- Center for Cancer Research, Medical University of Vienna, Vienna, Austria
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Huang, Wen-Yi (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
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- Moreno, Victor (författare)
- Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain
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- Murphy, Neil (författare)
- Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Newton, Christina C. (författare)
- Department of Population Science, American Cancer Society, Atlanta, Georgia
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- Nowak, Jonathan A. (författare)
- Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
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- Obón-Santacana, Mireia (författare)
- Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Ogino, Shuji (författare)
- Broad Institute of MIT and Harvard, MA, Cambridge, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Sun, Wei (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Toland, Amanda E. (författare)
- Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, OH, Columbus, United States
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- Trinh, Quang M. (författare)
- Ontario Institute for Cancer Research, ON, Toronto, Canada
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- Ugai, Tomotaka (författare)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Zaidi, Syed H. (författare)
- Ontario Institute for Cancer Research, ON, Toronto, Canada
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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- Phipps, Amanda I. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
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(creator_code:org_t)
- American Association For Cancer Research (AACR), 2024
- 2024
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 33:4, s. 534-546
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.METHODS: Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).RESULTS: 392 (9%) tumors were SBS88 positive. Among all cases, the highest quartile of fruit intake was associated with lower risk of SBS88-positive colorectal cancer than SBS88-negative colorectal cancer [odds ratio (OR) = 0.53, 95% confidence interval (CI) 0.37-0.76; OR = 0.75, 95% CI 0.66-0.85, respectively, Pheterogeneity = 0.047]. Among cohort studies, associations of body mass index (BMI), alcohol, and fruit intake with colorectal cancer risk differed by SBS88. BMI ≥30 kg/m2 was associated with worse colorectal cancer-specific survival among those SBS88-positive [hazard ratio (HR) = 3.40, 95% CI 1.47-7.84], but not among those SBS88-negative (HR = 0.97, 95% CI 0.78-1.21, Pheterogeneity = 0.066).CONCLUSIONS: Most epidemiologic factors did not differ by SBS88 for colorectal cancer risk or survival. Higher BMI may be associated with worse colorectal cancer-specific survival among those SBS88-positive; however, validation is needed in samples with whole-genome or whole-exome sequencing available.IMPACT: This study highlights the importance of identification of tumor phenotypes related to colorectal cancer and understanding potential heterogeneity for risk and survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Thomas, Claire E ...
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Georgeson, Peter
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Qu, Conghui
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Steinfelder, Rob ...
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Buchanan, Daniel ...
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Song, Mingyang
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visa fler...
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Harrison, Tabith ...
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Um, Caroline Y.
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Hullar, Meredith ...
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Jenkins, Mark A.
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van Guelpen, Bet ...
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Lynch, Brigid M.
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Melaku, Yohannes ...
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Huyghe, Jeroen R ...
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Aglago, Elom K.
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Berndt, Sonja I.
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Boardman, Lisa A ...
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Campbell, Peter ...
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Cao, Yin
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Chan, Andrew T.
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Drew, David A.
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Figueiredo, Jane ...
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French, Amy J.
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Giannakis, Mario ...
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Goode, Ellen L.
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Gruber, Stephen ...
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Gsur, Andrea
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Gunter, Marc J.
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Hoffmeister, Mic ...
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Hsu, Li
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Huang, Wen-Yi
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Moreno, Victor
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Murphy, Neil
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Newcomb, Polly A ...
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Newton, Christin ...
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Nowak, Jonathan ...
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Obón-Santacana, ...
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Ogino, Shuji
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Sun, Wei
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Toland, Amanda E ...
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Trinh, Quang M.
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Ugai, Tomotaka
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Zaidi, Syed H.
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Peters, Ulrike
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Phipps, Amanda I ...
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