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  • Cederlöf, ErikFinnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland (författare)

Antipsychotic medications and sleep problems in patients with schizophrenia

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-223506
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223506URI
  • https://doi.org/10.1016/j.schres.2024.03.015DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear.Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h).Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83–2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98–4.44, p < .001).Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Holm, MinnaFinnish Institute for Health and Welfare, Finland (författare)
  • Taipale, HeidiKarolinska Institutet, Sweden; Niuvanniemi Hospital, University of Eastern Finland, Finland (författare)
  • Tiihonen, JariKarolinska Institutet, Sweden (författare)
  • Tanskanen, AnttiKarolinska Institutet, Sweden (författare)
  • Lähteenvuo, MarkkuNiuvanniemi Hospital, University of Eastern Finland, Finland (författare)
  • Lahdensuo, KaislaDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland (författare)
  • Kampman, OlliUmeå universitet,Psykiatri,University of Tampere, Faculty of Medicine and Health Technology, Finland; University of Turku, Faculty of Medicine, Finland; The Pirkanmaa Wellbeing Services County, Department of Psychiatry, Tampere, Finland; The Wellbeing Services County of Ostrobothnia, Department of Psychiatry, Finland(Swepub:umu)kaol0168 (författare)
  • Wegelius, AskoDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland (författare)
  • Isometsä, ErkkiDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland (författare)
  • Kieseppä, TuulaFinnish Ministry of Social Affairs and Health, Finland (författare)
  • Palotie, AarnoInstitute for Molecular Medicine, Finland (författare)
  • Suvisaari, JaanaFinnish Institute for Health and Welfare, Finland (författare)
  • Paunio, TiinaFinnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland (författare)
  • Kyttälä, AijaFinnish Institute for Health and Welfare, Finland (författare)
  • Kämpe, AndersInstitute for Molecular Medicine Finland, Finland (författare)
  • Tuulio-Henriksson, AnnamariDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland (författare)
  • Ahola-Olli, AriInstitute for Molecular Medicine Finland, Finland (författare)
  • Toivola, AuliFinnish Institute for Health and Welfare, Finland (författare)
  • Neale, BenjaminFinnish Institute for Health and Welfare, Finland (författare)
  • Shen, Huei-yiInstitute for Molecular Medicine Finland, Finland (författare)
  • Västrik, ImreInstitute for Molecular Medicine Finland, Finland (författare)
  • Lönnqvist, JoukoFinnish Institute for Health and Welfare, Finland (författare)
  • Veijola, JuhaDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Department of Psychiatry, University Hospital of Oulu, Finland (författare)
  • Niemi-Pynttäri, JussiTampere University Hospital, Finland (författare)
  • Häkkinen, KatjaNiuvanniemi Hospital, University of Eastern Finland, Finland (författare)
  • Suokas, KimmoTampere University Hospital, Finland; Department of Psychiatry, Pirkanmaa Hospital District, Finland (författare)
  • Daly, MarkFinnish Institute for Health and Welfare, Finland; Institute for Molecular Medicine Finland, Finland; Massachusetts General Hospital Massachusetts General Hospital, United States (författare)
  • Ristiluoma, NooraFinnish Institute for Health and Welfare, Finland (författare)
  • Pietiläinen, OlliNeuroscience Center, HiLIFE, University of Helsinki, Finland (författare)
  • Kajanne, RistoInstitute for Molecular Medicine Finland, Finland (författare)
  • Hyman, Steven E.Finnish Institute for Health and Welfare, Finland (författare)
  • Singh, TarjinderFinnish Institute for Health and Welfare, Finland (författare)
  • Männynsalo, TeemuDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland (författare)
  • Jukuri, TuomasDepartment of Psychiatry, University Hospital of Oulu, Finland (författare)
  • Haaki, WillehardTurku University Hospital, Turku, Finland (författare)
  • Finnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, FinlandFinnish Institute for Health and Welfare, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Schizophrenia Research: Elsevier267, s. 230-2380920-99641573-2509

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