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Antipsychotic medications and sleep problems in patients with schizophrenia

Cederlöf, Erik (författare)
Finnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland
Holm, Minna (författare)
Finnish Institute for Health and Welfare, Finland
Taipale, Heidi (författare)
Karolinska Institutet, Sweden; Niuvanniemi Hospital, University of Eastern Finland, Finland
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Tiihonen, Jari (författare)
Karolinska Institutet, Sweden
Tanskanen, Antti (författare)
Karolinska Institutet, Sweden
Lähteenvuo, Markku (författare)
Niuvanniemi Hospital, University of Eastern Finland, Finland
Lahdensuo, Kaisla (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland
Kampman, Olli (författare)
Umeå universitet,Psykiatri,University of Tampere, Faculty of Medicine and Health Technology, Finland; University of Turku, Faculty of Medicine, Finland; The Pirkanmaa Wellbeing Services County, Department of Psychiatry, Tampere, Finland; The Wellbeing Services County of Ostrobothnia, Department of Psychiatry, Finland
Wegelius, Asko (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland
Isometsä, Erkki (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland
Kieseppä, Tuula (författare)
Finnish Ministry of Social Affairs and Health, Finland
Palotie, Aarno (författare)
Institute for Molecular Medicine, Finland
Suvisaari, Jaana (författare)
Finnish Institute for Health and Welfare, Finland
Paunio, Tiina (författare)
Finnish Institute for Health and Welfare, Finland; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland
Kyttälä, Aija (författare)
Finnish Institute for Health and Welfare, Finland
Kämpe, Anders (författare)
Institute for Molecular Medicine Finland, Finland
Tuulio-Henriksson, Annamari (författare)
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
Ahola-Olli, Ari (författare)
Institute for Molecular Medicine Finland, Finland
Toivola, Auli (författare)
Finnish Institute for Health and Welfare, Finland
Neale, Benjamin (författare)
Finnish Institute for Health and Welfare, Finland
Shen, Huei-yi (författare)
Institute for Molecular Medicine Finland, Finland
Västrik, Imre (författare)
Institute for Molecular Medicine Finland, Finland
Lönnqvist, Jouko (författare)
Finnish Institute for Health and Welfare, Finland
Veijola, Juha (författare)
Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland; Department of Psychiatry, University Hospital of Oulu, Finland
Niemi-Pynttäri, Jussi (författare)
Tampere University Hospital, Finland
Häkkinen, Katja (författare)
Niuvanniemi Hospital, University of Eastern Finland, Finland
Suokas, Kimmo (författare)
Tampere University Hospital, Finland; Department of Psychiatry, Pirkanmaa Hospital District, Finland
Daly, Mark (författare)
Finnish Institute for Health and Welfare, Finland; Institute for Molecular Medicine Finland, Finland; Massachusetts General Hospital Massachusetts General Hospital, United States
Ristiluoma, Noora (författare)
Finnish Institute for Health and Welfare, Finland
Pietiläinen, Olli (författare)
Neuroscience Center, HiLIFE, University of Helsinki, Finland
Kajanne, Risto (författare)
Institute for Molecular Medicine Finland, Finland
Hyman, Steven E. (författare)
Finnish Institute for Health and Welfare, Finland
Singh, Tarjinder (författare)
Finnish Institute for Health and Welfare, Finland
Männynsalo, Teemu (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Finland
Jukuri, Tuomas (författare)
Department of Psychiatry, University Hospital of Oulu, Finland
Haaki, Willehard (författare)
Turku University Hospital, Turku, Finland
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Schizophrenia Research. - : Elsevier. - 0920-9964 .- 1573-2509. ; 267, s. 230-238
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Sleep problems are common and related to a worse quality of life in patients with schizophrenia. Almost all patients with schizophrenia use antipsychotic medications, which usually increase sleep. Still, the differences in subjective sleep outcomes between different antipsychotic medications are not entirely clear.Methods: This study assessed 5466 patients with schizophrenia and is part of the nationwide Finnish SUPER study. We examined how the five most common antipsychotic medications (clozapine, olanzapine, quetiapine, aripiprazole, and risperidone) associate with questionnaire-based sleep problems in logistic regression analyses, including head-to-head analyses between different antipsychotic medications. The sleep problems were difficulties initiating sleep, early morning awakenings, fatigue, poor sleep quality, short (≤6 h) and long sleep duration (≥10 h).Results: The average number of antipsychotic medications was 1.59 per patient. Clozapine was associated with long sleep duration (49.0 % of clozapine users vs 30.2 % of other patients, OR = 2.05, 95 % CI 1.83–2.30, p < .001). Olanzapine and risperidone were in head-to-head analyses associated with less sleep problems than patients using aripiprazole, quetiapine, or no antipsychotic medication. Aripiprazole and quetiapine were associated with more insomnia symptoms and poorer sleep quality. Patients without antipsychotic medications (N = 159) had poorer sleep quality than patients with antipsychotic use, and short sleep duration was common (21.5 % of patients using antipsychotics vs 7.8 % of patients using antipsychotics, OR = 2.97, 95 % CI 1.98–4.44, p < .001).Conclusions: Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Antipsychotics
Hypersomnia
Insomnia
Schizophrenia
Sleep

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