Sökning: L773:1535 9484
> (2020-2024) >
Proteomic profiling...
Proteomic profiling of muscular adaptations to short-term concentric versus eccentric exercise training in humans
-
- Du, Jiawei (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
- Yun, Hezhang (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
- Wang, Hongsheng (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
visa fler...
-
- Bai, Xin (författare)
- Beijing Sports University Community Health Service Center, Beijing Sport University, Beijing, China
-
- Su, Yuhui (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
- Ge, Xiaochuan (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
- Wang, Yang (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Institute of Sports and Health, Beijing Sport University, Beijing, China
-
- Gu, Boya (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Institute of Sports and Health, Beijing Sport University, Beijing, China
-
- Zhao, Li (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Department of Exercise Physiology, Beijing Sport University, Beijing, China
-
- Yu, Ji-Guo (författare)
- Umeå universitet,Avdelningen för idrottsmedicin
-
- Song, Yafeng (författare)
- Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China; Institute of Sports and Health, Beijing Sport University, Beijing, China; Academy of Plateau Science and Sustainability, Qinghai Normal University, Xining, China
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
-
Ingår i: Molecular & Cellular Proteomics. - : Elsevier. - 1535-9476 .- 1535-9484. ; 23:4
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The molecular mechanisms underlying muscular adaptations to concentric (CON) and eccentric (ECC) exercise training have been extensively explored. However, most previous studies have focused on specifically selected proteins, thus, unable to provide a comprehensive protein profile and potentially missing the crucial mechanisms underlying muscular adaptation to exercise training. We herein aimed to investigate proteomic profiles of human skeletal muscle in response to short-term resistance training. Twenty young males were randomly and evenly assigned to two groups to complete a 4-week either ECC or CON training program. Measurements of body composition and physiological function of the quadriceps femoris were conducted both before and after the training. Muscle biopsies from the vastus lateralis of randomly selected participants (five in ECC and four in CON) of both before and after the training were analyzed using the liquid-chromatography tandem mass spectrometry in combination with bioinformatics analysis. Neither group presented a significant difference in body composition or leg muscle mass; however, muscle peak torque, total work, and maximal voluntary contraction were significantly increased after the training in both groups. Proteomics analysis revealed 122 differentially abundant proteins (DAPs; p value < 0.05 & fold change >1.5 or <0.67) in ECC, of which the increased DAPs were mainly related to skeletal muscle contraction and cytoskeleton and enriched specifically in the pentose phosphate pathway, extracellular matrix-receptor interaction, and PI3K-Akt signaling pathway, whereas the decreased DAPs were associated with the mitochondrial respiratory chain. One hundred one DAPs were identified in CON, of which the increased DAPs were primarily involved in translation/ protein synthesis and the mitochondria respiratory, whereas the decreased DAPs were related to metabolic processes, cytoskeleton, and de-ubiquitination. In conclusion, the 4-week CON and ECC training resulted in distinctly different proteomic profiles, especially in proteins related to muscular structure and metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Du, Jiawei
-
Yun, Hezhang
-
Wang, Hongsheng
-
Bai, Xin
-
Su, Yuhui
-
Ge, Xiaochuan
-
visa fler...
-
Wang, Yang
-
Gu, Boya
-
Zhao, Li
-
Yu, Ji-Guo
-
Song, Yafeng
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Fysiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Idrottsvetenskap
- Artiklar i publikationen
-
Molecular & Cell ...
- Av lärosätet
-
Umeå universitet