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Long-term ambient a...
Long-term ambient air pollution and coronary atherosclerosis : results from the Swedish SCAPIS study
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- Kilbo Edlund, Karl (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Andersson, Eva M., 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Asker, Christian (författare)
- Swedish Meteorological & Hydrological Institute, Norrköping, Sweden
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visa fler...
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- Barregård, Lars, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Wallenberglaboratoriet,Institute of Medicine,Institute of Neuroscience and Physiology, Department of Physiology,Institute of Medicine, Department of Molecular and Clinical Medicine,Institute of Neuroscience and Physiology, Department of Pharmacology,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Clinical Physiology Sahlgrenska University Hospital, Göteborg, Sweden
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- Eneroth, Kristina (författare)
- SLB-analys, Environment and Health Administration, Stockholm, Sweden
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- Jernberg, Tomas (författare)
- Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden
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- Ljunggren, Stefan (författare)
- Occupational and Environmental Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Molnár, Peter, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Nilsson Sommar, Johan (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Oudin, Anna (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Sweden
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- Pershagen, Göran (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
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- Persson, Åsa (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
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- Pyko, Andrei (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
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- Spanne, Mårten (författare)
- Environmental Department, City of Malmö, Malmö, Sweden
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- Tondel, Martin (författare)
- Occupational and Environmental Medicine, Department of Medical Sciences, Medical Faculty, Uppsala University, Sweden; Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Ögren, Mikael (författare)
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Ljungman, Petter (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden
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- Stockfelt, Leo, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484.
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background and aims: Despite firm evidence for an association between long-term ambient air pollution exposure and cardiovascular morbidity and mortality, results from epidemiological studies on the association between air pollution exposure and atherosclerosis have not been consistent. We investigated associations between long-term low-level air pollution exposure and coronary atherosclerosis.Methods: We performed a cross-sectional analysis in the large Swedish CArdioPulmonary bioImaging Study (SCAPIS, n = 30 154), a random general population sample. Concentrations of total and locally emitted particulate matter <2.5 μm (PM2.5), <10 μm (PM10), and nitrogen oxides (NOx) at the residential address were modelled using high-resolution dispersion models. We estimated associations between air pollution exposures and segment involvement score (SIS), coronary artery calcification score (CACS), number of non-calcified plaques (NCP), and number of significant stenoses, using ordinal regression models extensively adjusted for potential confounders.Results: Median 10-year average PM2.5 exposure was 6.2 μg/m3 (range 3.5–13.4 μg/m3). 51 % of participants were women and 51 % were never-smokers. None of the assessed pollutants were associated with a higher SIS or CACS. Exposure to PM2.5 was associated with NCP (adjusted OR 1.34, 95 % CI 1.13, 1.58, per 2.05 μg/m3). Associations with significant stenoses were inconsistent.Conclusions: In this large, middle-aged general population sample with low exposure levels, air pollution was not associated with measures of total burden of coronary atherosclerosis. However, PM2.5 appeared to be associated with a higher prevalence of non-calcified plaques. The results suggest that increased risk of early-stage atherosclerosis or rupture, but not increased total atherosclerotic burden, may be a pathway for long-term air pollution effects on cardiovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Meteorologi och atmosfärforskning (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Meteorology and Atmospheric Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Air pollution
- Atherosclerosis
- Cardiovascular diseases
- Coronary artery disease
- Nitrogen oxides
- Particulate matter
- Air pollution; Atherosclerosis; Cardiovascular diseases; Coronary artery disease; Nitrogen oxides; Particulate matter
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Kilbo Edlund, Ka ...
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Andersson, Eva M ...
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Asker, Christian
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Barregård, Lars, ...
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Bergström, Göran ...
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Eneroth, Kristin ...
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visa fler...
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Jernberg, Tomas
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Ljunggren, Stefa ...
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Molnár, Peter, 1 ...
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Nilsson Sommar, ...
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Oudin, Anna
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Pershagen, Göran
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Persson, Åsa
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Pyko, Andrei
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Spanne, Mårten
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Tondel, Martin
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Ögren, Mikael
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Ljungman, Petter
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Stockfelt, Leo, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Meteorologi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Umeå universitet
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Göteborgs universitet