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Sökning: WFRF:(Witt Stephanie H.) > (2024) > Maternal age is rel...

Maternal age is related to offspring DNA methylation : a meta-analysis of results from the pace consortium

Yeung, Edwina (författare)
Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, MD, Bethesda, United States
Biedrzycki, Richard J. (författare)
Division of Intramural Research, Glotech Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD, Bethesda, United States
Gómez Herrera, Laura C. (författare)
ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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Issarapu, Prachand (författare)
MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
Dou, John (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Marques, Irene Fontes (författare)
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Mansuri, Sohail Rafik (författare)
Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Telangana, Hyderabad, India
Page, Christian Magnus (författare)
Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway
Harbs, Justin (författare)
Umeå universitet,Institutionen för diagnostik och intervention,Onkologi
Khodasevich, Dennis (författare)
Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
Poisel, Eric (författare)
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Niu, Zhongzheng (författare)
Department of Population and Public Health Science, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Allard, Catherine (författare)
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), QC, Sherbrooke, Canada
Casey, Emma (författare)
Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
Berstein, Fernanda Morales (författare)
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
Mancano, Giulia (författare)
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
Elliott, Hannah R. (författare)
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
Richmond, Rebecca (författare)
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Bristol Medical School Population Health Sciences, University of Bristol, Bristol, United Kingdom
He, Yiyan (författare)
Research Unit of Population Health, University of Oulu, Oulu, Finland
Ronkainen, Justiina (författare)
Research Unit of Population Health, University of Oulu, Oulu, Finland
Sebert, Sylvain (författare)
Research Unit of Population Health, University of Oulu, Oulu, Finland
Bell, Erin M. (författare)
Department of Environmental Health Sciences and Epidemiology and Biostatistics, University at Albany School of Public Health, NY, Albany, United States
Sharp, Gemma (författare)
Department of Psychology, University of Exeter, Exeter, United Kingdom
Mumford, Sunni L. (författare)
Department of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
Schisterman, Enrique F. (författare)
Department of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States
Chandak, Giriraj R. (författare)
Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Telangana, Hyderabad, India
Fall, Caroline H. D. (författare)
MRC Lifecourse Epidemiology Centre, University of Southampton, UK, Southampton, United Kingdom
Sahariah, Sirazul A. (författare)
Centre for the Study of Social Change, Mumbai, India
Silver, Matt J. (författare)
MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
Prentice, Andrew M. (författare)
MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia
Bouchard, Luigi (författare)
Department of Biochemistry and Functional Genomics, Centre intégré Universitaire de santé et de Services Sociaux (CIUSSS) du Saguenay-Lac-St-Jean, Université de Sherbrooke, QC, Sherbrooke, Canada; Department of Laboratory Medicine, CIUSSS du Saguenay-Lac-Saint-Jean – Hôpital de Chicoutimi, QC, Chicoutimi, Canada
Domellöf, Magnus, 1963- (författare)
Umeå universitet,Pediatrik
West, Christina E. (författare)
Umeå universitet,Pediatrik
Holland, Nina (författare)
Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
Cardenas, Andres (författare)
Department of Epidemiology and Population Health, Stanford University, CA, Stanford, United States
Eskenazi, Brenda (författare)
Environmental Health Sciences, Berkeley Public Health, CERCH, University of California, CA, Berkeley, United States
Zillich, Lea (författare)
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Witt, Stephanie H. (författare)
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Send, Tabea (författare)
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Breton, Carrie (författare)
Department of Population and Public Health Science, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Bakulski, Kelly M. (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Fallin, M. Daniele (författare)
Dean's Office, Rollins School of Public Health, Emory University, GA, Atlanta, United States
Schmidt, Rebecca J. (författare)
Department of Public Health Sciences and the M.I.N.D. Institute, School of Medicine, University of California, CA, Davis, United States
Stein, Dan J. (författare)
Neuroscience Institute, University of Cape Town, Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa
Zar, Heather J. (författare)
South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa
Jaddoe, Vincent W. V. (författare)
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Wright, John (författare)
Bradford Institute for Health Research, Temple Bank House, Bradford Royal Infirmary, Bradford, United Kingdom
Grazuleviciene, Regina (författare)
Department of Environmental Sciences, Vytautas Magnus University, Kaunas, Lithuania
Gutzkow, Kristine Bjerve (författare)
Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Sunyer, Jordi (författare)
ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM-Parc Salut Mar, Barcelona, Spain
Huels, Anke (författare)
Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, GA, Atlanta, United States
Vrijheid, Martine (författare)
ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Harlid, Sophia, 1978- (författare)
Umeå universitet,Institutionen för diagnostik och intervention,Onkologi
London, Stephanie (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, Durham, United States
Hivert, Marie-France (författare)
Division of Chronic Disease Research across the Lifecourse (CoRAL); Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, MA, Boston, United States; Diabetes Unit, Massachusetts General Hospital, MA, Boston, United States
Felix, Janine (författare)
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Bustamante, Mariona (författare)
ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Guan, Weihua (författare)
Division of Biostatistics, School of Public Health, University of Minnesota, MN, Minneapolis, United States
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Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, MD, Bethesda, United States Division of Intramural Research, Glotech Inc, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD, Bethesda, United States (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Aging Cell. - : John Wiley & Sons. - 1474-9718 .- 1474-9726.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

aging
child
DNA methylation
melatonin
receptor

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ref (ämneskategori)
art (ämneskategori)

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