Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition

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Circulating free insulin-like growth factor-I and prostate cancer : a case-control study nested in the European prospective investigation into cancer and nutrition

Cheng, Tuck Seng (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom

Noor, Urwah (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom

Watts, Eleanor (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States

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Pollak, Michael (författare): Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada

Wang, Ye (författare): Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada

McKay, James (författare): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Atkins, Joshua (författare): Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France

Masala, Giovanna (författare): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy

Sánchez, Maria-Jose (författare): Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain

Agudo, Antonio (författare): Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain

Castilla, Jesús (författare): Instituto de Salud Pública de Navarra - IdiSNA, Pamplona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain

Aune, Dagfinn (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevå, Oslo, Norway

Colorado-Yohar, Sandra M. (författare): Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia

Manfredi, Luca (författare): Centre for Biostatistics, Epidemiology, Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy

Gunter, Marc J. (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC- WHO), Lyon, France

Pala, Valeria (författare): Epidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Josefsson, Andreas, 1979- (författare): Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Urologi och andrologi,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Key, Timothy J. (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom

Smith-Byrne, Karl (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom

Travis, Ruth C. (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom

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BioMed Central (BMC), 2024
2024
Engelska.
Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 24:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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BACKGROUND: Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavailable form), and few studies have investigated the association of circulating free IGF-I with prostate cancer risk.METHODS: We analyzed data from 767 prostate cancer cases and 767 matched controls nested within the European Prospective Investigation into Cancer and Nutrition cohort, with an average of 14-years (interquartile range = 2.9) follow-up. Matching variables were study center, length of follow-up, age, and time of day and fasting duration at blood collection. Circulating free IGF-I concentration was measured in serum samples collected at recruitment visit (mean age 55 years old; standard deviation = 7.1) using an enzyme-linked immunosorbent assay (ELISA). Conditional logistic regressions were performed to examine the associations of free IGF-I with risk of prostate cancer overall and subdivided by time to diagnosis (≤ 14 and > 14 years), and tumor characteristics.RESULTS: Circulating free IGF-I concentrations (in fourths and as a continuous variable) were not associated with prostate cancer risk overall (odds ratio [OR] = 1.00 per 0.1 nmol/L increment, 95% CI: 0.99, 1.02) or by time to diagnosis, or with prostate cancer subtypes, including tumor stage and histological grade.CONCLUSIONS: Estimated circulating free IGF-I was not associated with prostate cancer risk. Further research may consider other assay methods that estimate bioavailable IGF-I to provide more insight into the well-substantiated association between circulating total IGF-I and subsequent prostate cancer risk.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: BMC Cancer

Av lärosätet: Umeå universitet

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Circulating free insulin-like growth factor-I and prostate cancer : a case-control study nested in the European prospective investigation into cancer and nutrition

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