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  • Cheng, Tuck SengCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom (författare)

Circulating free insulin-like growth factor-I and prostate cancer : a case-control study nested in the European prospective investigation into cancer and nutrition

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • BioMed Central (BMC),2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-225942
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-225942URI
  • https://doi.org/10.1186/s12885-023-11425-wDOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavailable form), and few studies have investigated the association of circulating free IGF-I with prostate cancer risk.METHODS: We analyzed data from 767 prostate cancer cases and 767 matched controls nested within the European Prospective Investigation into Cancer and Nutrition cohort, with an average of 14-years (interquartile range = 2.9) follow-up. Matching variables were study center, length of follow-up, age, and time of day and fasting duration at blood collection. Circulating free IGF-I concentration was measured in serum samples collected at recruitment visit (mean age 55 years old; standard deviation = 7.1) using an enzyme-linked immunosorbent assay (ELISA). Conditional logistic regressions were performed to examine the associations of free IGF-I with risk of prostate cancer overall and subdivided by time to diagnosis (≤ 14 and > 14 years), and tumor characteristics.RESULTS: Circulating free IGF-I concentrations (in fourths and as a continuous variable) were not associated with prostate cancer risk overall (odds ratio [OR] = 1.00 per 0.1 nmol/L increment, 95% CI: 0.99, 1.02) or by time to diagnosis, or with prostate cancer subtypes, including tumor stage and histological grade.CONCLUSIONS: Estimated circulating free IGF-I was not associated with prostate cancer risk. Further research may consider other assay methods that estimate bioavailable IGF-I to provide more insight into the well-substantiated association between circulating total IGF-I and subsequent prostate cancer risk.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Noor, UrwahCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom (författare)
  • Watts, EleanorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States (författare)
  • Pollak, MichaelOncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada (författare)
  • Wang, YeOncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, QC, Montreal, Canada (författare)
  • McKay, JamesGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Atkins, JoshuaGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (författare)
  • Sánchez, Maria-JoseEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Agudo, AntonioUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain (författare)
  • Castilla, JesúsInstituto de Salud Pública de Navarra - IdiSNA, Pamplona, Spain; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevå, Oslo, Norway (författare)
  • Colorado-Yohar, Sandra M.Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (författare)
  • Manfredi, LucaCentre for Biostatistics, Epidemiology, Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy (författare)
  • Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC- WHO), Lyon, France (författare)
  • Pala, ValeriaEpidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Josefsson, Andreas,1979-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Urologi och andrologi,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:umu)aasjon01 (författare)
  • Key, Timothy J.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom (författare)
  • Smith-Byrne, KarlCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom (författare)
  • Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United Kingdom (författare)
  • Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building ,Old Road Campus, Oxford, United KingdomDivision of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Cancer: BioMed Central (BMC)24:11471-2407

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