Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study

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Hepatic steatosis, metabolic dysfunction and risk of mortality : findings from a multinational prospective cohort study

Mayén, Ana-Lucia (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Sabra, Mirna (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Aglago, Elom K. (author): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Perlemuter, Gabriel (author): INSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France

Voican, Cosmin (author): INSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France

Ramos, Ines (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Debras, Charlotte (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Blanco, Jessica (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Viallon, Vivian (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Ferrari, Pietro (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Olsen, Anja (author): Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark

Tjønneland, Anne (author): Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark

Langmann, Fie (author): Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark

Dahm, Christina C. (author): Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark

Rothwell, Joseph (author): UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France

Laouali, Nasser (author): UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France

Marques, Chloé (author): UVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France

Schulze, Matthias B. (author): Dept. of Molecular Epidemiology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany

Katzke, Verena (author): Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Kaaks, Rudolf (author): Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Palli, Domenico (author): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy

Macciotta, Alessandra (author): Department of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, Public Health (C-BEPH), University of Turin, Turin, Italy

Panico, Salvatore (author): Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy

Tumino, Rosario (author): Hyblean Association for Epidemiological Research, Ragusa, Italy

Agnoli, Claudia (author): Department of Research Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy

Farràs, Marta (author): Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain

Molina-Montes, Esther (author): Department of Nutrition and Food Science, Campus of Cartuja, University of Granada, Granada, Spain; Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; Institute of Nutrition and Food Technology (INYTA) 'José Mataix', Biomedical Research Centre, University of Granada, Granada, Spain

Amiano, Pilar (author): Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain

Chirlaque, María-Dolores (author): Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain

Castilla, Jesús (author): Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Navarra Public Health Institute - IdiSNA, Pamplona, Spain

Werner, Mårten (author): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Bodén, Stina (author): Umeå universitet,Pediatrik

Heath, Alicia K. (author): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Tsilidis, Kostas (author): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Aune, Dagfinn (author): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevål, Oslo, Norway

Weiderpass, Elisabete (author): Office of the Director, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Freisling, Heinz (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

Gunter, Marc J. (author): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

Jenab, Mazda (author): Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France

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BioMed Central (BMC), 2024
2024
English.
In: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 22:1

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD and MetS with overall and cause-specific mortality.METHODS: We used dietary, lifestyle, anthropometric and metabolic biomarker data from a random subsample of 15,784 EPIC cohort participants. NAFLD was assessed using the fatty liver index (FLI) and MetS using the revised definition. Indices for metabolic dysfunction-associated fatty liver disease (MAFLD) were calculated. The individual associations of these indices with overall and cause-specific mortality were assessed using multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs). As a subobjective, risk associations with adaptations of new classifications of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic and alcohol-related liver disease (MetALD) were also assessed.RESULTS: Among the 15,784 sub-cohort participants, a total of 1997 deaths occurred (835 due to cancer, 520 to CVD, 642 to other causes) over a median 15.6 (IQR, 12.3-17.1) years of follow-up. Compared to an FLI < 30, FLI ≥ 60 was associated with increased risks of overall mortality (HR = 1.44, 95%CI = 1.27-1.63), and deaths from cancer (HR = 1.32, 95%CI = 1.09-1.60), CVD (HR = 2.06, 95% CI = 1.61-2.63) or other causes (HR = 1.21, 95%CI = 0.97-1.51). Mortality risk associations were also elevated for individuals with MAFLD compared to those without. Individuals with MetS were at increased risk of all mortality endpoints, except cancer-specific mortality. MASLD and MetALD were associated with higher risk of overall mortality.CONCLUSIONS: Our findings based on a prospective cohort suggest that individuals with hepatic steatosis or metabolic dysfunction have a higher overall and cause-specific mortality risk.

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Hepatic steatosis, metabolic dysfunction and risk of mortality : findings from a multinational prospective cohort study

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